Lasp1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis
Fibroblast-like synoviocytes are important mediators of joint pathology in rheumatoid arthritis (RA). Here the authors show that Lasp1 is epigenetically regulated and highly expressed by these cells in RA and its deletion can limit joint pathology in a mouse model of inflammatory arthritis.
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Nature Portfolio
2021
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oai:doaj.org-article:6eeabbe32b3249c9843c922ebc4963402021-12-02T17:23:50ZLasp1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis10.1038/s41467-021-23706-82041-1723https://doaj.org/article/6eeabbe32b3249c9843c922ebc4963402021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23706-8https://doaj.org/toc/2041-1723Fibroblast-like synoviocytes are important mediators of joint pathology in rheumatoid arthritis (RA). Here the authors show that Lasp1 is epigenetically regulated and highly expressed by these cells in RA and its deletion can limit joint pathology in a mouse model of inflammatory arthritis.Denise BeckmannAnja Römer-HillmannAnnika KrauseUwe HansenCorinna WehmeyerJohanna IntemannDavid J. J. de GorterBerno DankbarJan HillenMarianne HeitzmannIsabell BegemannMilos GalicToni WeinhageDirk FoellRizi AiJoachim KremerskothenHans P. KienerSylvia MüllerThomas KamradtChristopher SchröderElsa LeitãoBernhard HorsthemkePhilip RosenstielKarl NordströmGilles GasparoniNina GasparoniJörn WalterNa LiXinyi YangHo-Ryun ChungHermann PavenstädtNico LindemannHans J. SchnittlerWei WangGary S. FiresteinThomas PapAdelheid Korb-PapNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021) |
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DOAJ |
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EN |
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Science Q Denise Beckmann Anja Römer-Hillmann Annika Krause Uwe Hansen Corinna Wehmeyer Johanna Intemann David J. J. de Gorter Berno Dankbar Jan Hillen Marianne Heitzmann Isabell Begemann Milos Galic Toni Weinhage Dirk Foell Rizi Ai Joachim Kremerskothen Hans P. Kiener Sylvia Müller Thomas Kamradt Christopher Schröder Elsa Leitão Bernhard Horsthemke Philip Rosenstiel Karl Nordström Gilles Gasparoni Nina Gasparoni Jörn Walter Na Li Xinyi Yang Ho-Ryun Chung Hermann Pavenstädt Nico Lindemann Hans J. Schnittler Wei Wang Gary S. Firestein Thomas Pap Adelheid Korb-Pap Lasp1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis |
| description |
Fibroblast-like synoviocytes are important mediators of joint pathology in rheumatoid arthritis (RA). Here the authors show that Lasp1 is epigenetically regulated and highly expressed by these cells in RA and its deletion can limit joint pathology in a mouse model of inflammatory arthritis. |
| format |
article |
| author |
Denise Beckmann Anja Römer-Hillmann Annika Krause Uwe Hansen Corinna Wehmeyer Johanna Intemann David J. J. de Gorter Berno Dankbar Jan Hillen Marianne Heitzmann Isabell Begemann Milos Galic Toni Weinhage Dirk Foell Rizi Ai Joachim Kremerskothen Hans P. Kiener Sylvia Müller Thomas Kamradt Christopher Schröder Elsa Leitão Bernhard Horsthemke Philip Rosenstiel Karl Nordström Gilles Gasparoni Nina Gasparoni Jörn Walter Na Li Xinyi Yang Ho-Ryun Chung Hermann Pavenstädt Nico Lindemann Hans J. Schnittler Wei Wang Gary S. Firestein Thomas Pap Adelheid Korb-Pap |
| author_facet |
Denise Beckmann Anja Römer-Hillmann Annika Krause Uwe Hansen Corinna Wehmeyer Johanna Intemann David J. J. de Gorter Berno Dankbar Jan Hillen Marianne Heitzmann Isabell Begemann Milos Galic Toni Weinhage Dirk Foell Rizi Ai Joachim Kremerskothen Hans P. Kiener Sylvia Müller Thomas Kamradt Christopher Schröder Elsa Leitão Bernhard Horsthemke Philip Rosenstiel Karl Nordström Gilles Gasparoni Nina Gasparoni Jörn Walter Na Li Xinyi Yang Ho-Ryun Chung Hermann Pavenstädt Nico Lindemann Hans J. Schnittler Wei Wang Gary S. Firestein Thomas Pap Adelheid Korb-Pap |
| author_sort |
Denise Beckmann |
| title |
Lasp1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis |
| title_short |
Lasp1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis |
| title_full |
Lasp1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis |
| title_fullStr |
Lasp1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis |
| title_full_unstemmed |
Lasp1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis |
| title_sort |
lasp1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/6eeabbe32b3249c9843c922ebc496340 |
| work_keys_str_mv |
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