A multi-ethnic genome-wide association study implicates collagen matrix integrity and cell differentiation pathways in keratoconus
Alison Hardcastle et al. report a genome-wide meta-analysis of keratoconus, a condition affecting the cornea that causes blurred vision and often leads to blindness. They identify 36 genomic regions associated with keratoconus, 31 of which are novel, and show that the genes in these regions implicat...
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Nature Portfolio
2021
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oai:doaj.org-article:6eed77457b784436985e138a87c605442021-12-02T13:20:00ZA multi-ethnic genome-wide association study implicates collagen matrix integrity and cell differentiation pathways in keratoconus10.1038/s42003-021-01784-02399-3642https://doaj.org/article/6eed77457b784436985e138a87c605442021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01784-0https://doaj.org/toc/2399-3642Alison Hardcastle et al. report a genome-wide meta-analysis of keratoconus, a condition affecting the cornea that causes blurred vision and often leads to blindness. They identify 36 genomic regions associated with keratoconus, 31 of which are novel, and show that the genes in these regions implicate genetic pathways involved in collagen matrix integrity and cell differentiation.Alison J. HardcastlePetra LiskovaYelena BykhovskayaBennet J. McComishAlice E. DavidsonChris F. InglehearnXiaohui LiHélène ChoquetMahmoud HabeebSionne E. M. LucasSrujana SahebjadaNikolas PontikosKarla E. Rojas LopezAnthony P. KhawajaManir AliLubica DudakovaPavlina SkalickaBart T. H. Van DoorenAnnette J. M. GeerardsChristoph W. HaudumValeria Lo FaroAbi TenenMark J. SimcoeKarina PatasovaDarioush YarrandJie YinSalina SiddiquiAine RiceLayal Abi FarrajYii-Der Ida ChenJugnoo S. RahiRonald M. KraussElisabeth TheuschJac C. CharlesworthLoretta Szczotka-FlynnCarmel ToomesMagda A. Meester-SmoorAndrea J. RichardsonPaul A. MitchellKent D. TaylorRonald B. MellesAnthony J. AldaveRichard A. MillsKe CaoElsie ChanMark D. DaniellJie Jin WangJerome I. RotterAlex W. HewittStuart MacGregorCaroline C. W. KlaverWishal D. RamdasJamie E. CraigSudha K. IyengarDavid O’BrartEric JorgensonPaul N. BairdYaron S. RabinowitzKathryn P. BurdonChris J. HammondStephen J. TuftPirro G. HysiNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Biology (General) QH301-705.5 |
| spellingShingle |
Biology (General) QH301-705.5 Alison J. Hardcastle Petra Liskova Yelena Bykhovskaya Bennet J. McComish Alice E. Davidson Chris F. Inglehearn Xiaohui Li Hélène Choquet Mahmoud Habeeb Sionne E. M. Lucas Srujana Sahebjada Nikolas Pontikos Karla E. Rojas Lopez Anthony P. Khawaja Manir Ali Lubica Dudakova Pavlina Skalicka Bart T. H. Van Dooren Annette J. M. Geerards Christoph W. Haudum Valeria Lo Faro Abi Tenen Mark J. Simcoe Karina Patasova Darioush Yarrand Jie Yin Salina Siddiqui Aine Rice Layal Abi Farraj Yii-Der Ida Chen Jugnoo S. Rahi Ronald M. Krauss Elisabeth Theusch Jac C. Charlesworth Loretta Szczotka-Flynn Carmel Toomes Magda A. Meester-Smoor Andrea J. Richardson Paul A. Mitchell Kent D. Taylor Ronald B. Melles Anthony J. Aldave Richard A. Mills Ke Cao Elsie Chan Mark D. Daniell Jie Jin Wang Jerome I. Rotter Alex W. Hewitt Stuart MacGregor Caroline C. W. Klaver Wishal D. Ramdas Jamie E. Craig Sudha K. Iyengar David O’Brart Eric Jorgenson Paul N. Baird Yaron S. Rabinowitz Kathryn P. Burdon Chris J. Hammond Stephen J. Tuft Pirro G. Hysi A multi-ethnic genome-wide association study implicates collagen matrix integrity and cell differentiation pathways in keratoconus |
| description |
Alison Hardcastle et al. report a genome-wide meta-analysis of keratoconus, a condition affecting the cornea that causes blurred vision and often leads to blindness. They identify 36 genomic regions associated with keratoconus, 31 of which are novel, and show that the genes in these regions implicate genetic pathways involved in collagen matrix integrity and cell differentiation. |
| format |
article |
| author |
Alison J. Hardcastle Petra Liskova Yelena Bykhovskaya Bennet J. McComish Alice E. Davidson Chris F. Inglehearn Xiaohui Li Hélène Choquet Mahmoud Habeeb Sionne E. M. Lucas Srujana Sahebjada Nikolas Pontikos Karla E. Rojas Lopez Anthony P. Khawaja Manir Ali Lubica Dudakova Pavlina Skalicka Bart T. H. Van Dooren Annette J. M. Geerards Christoph W. Haudum Valeria Lo Faro Abi Tenen Mark J. Simcoe Karina Patasova Darioush Yarrand Jie Yin Salina Siddiqui Aine Rice Layal Abi Farraj Yii-Der Ida Chen Jugnoo S. Rahi Ronald M. Krauss Elisabeth Theusch Jac C. Charlesworth Loretta Szczotka-Flynn Carmel Toomes Magda A. Meester-Smoor Andrea J. Richardson Paul A. Mitchell Kent D. Taylor Ronald B. Melles Anthony J. Aldave Richard A. Mills Ke Cao Elsie Chan Mark D. Daniell Jie Jin Wang Jerome I. Rotter Alex W. Hewitt Stuart MacGregor Caroline C. W. Klaver Wishal D. Ramdas Jamie E. Craig Sudha K. Iyengar David O’Brart Eric Jorgenson Paul N. Baird Yaron S. Rabinowitz Kathryn P. Burdon Chris J. Hammond Stephen J. Tuft Pirro G. Hysi |
| author_facet |
Alison J. Hardcastle Petra Liskova Yelena Bykhovskaya Bennet J. McComish Alice E. Davidson Chris F. Inglehearn Xiaohui Li Hélène Choquet Mahmoud Habeeb Sionne E. M. Lucas Srujana Sahebjada Nikolas Pontikos Karla E. Rojas Lopez Anthony P. Khawaja Manir Ali Lubica Dudakova Pavlina Skalicka Bart T. H. Van Dooren Annette J. M. Geerards Christoph W. Haudum Valeria Lo Faro Abi Tenen Mark J. Simcoe Karina Patasova Darioush Yarrand Jie Yin Salina Siddiqui Aine Rice Layal Abi Farraj Yii-Der Ida Chen Jugnoo S. Rahi Ronald M. Krauss Elisabeth Theusch Jac C. Charlesworth Loretta Szczotka-Flynn Carmel Toomes Magda A. Meester-Smoor Andrea J. Richardson Paul A. Mitchell Kent D. Taylor Ronald B. Melles Anthony J. Aldave Richard A. Mills Ke Cao Elsie Chan Mark D. Daniell Jie Jin Wang Jerome I. Rotter Alex W. Hewitt Stuart MacGregor Caroline C. W. Klaver Wishal D. Ramdas Jamie E. Craig Sudha K. Iyengar David O’Brart Eric Jorgenson Paul N. Baird Yaron S. Rabinowitz Kathryn P. Burdon Chris J. Hammond Stephen J. Tuft Pirro G. Hysi |
| author_sort |
Alison J. Hardcastle |
| title |
A multi-ethnic genome-wide association study implicates collagen matrix integrity and cell differentiation pathways in keratoconus |
| title_short |
A multi-ethnic genome-wide association study implicates collagen matrix integrity and cell differentiation pathways in keratoconus |
| title_full |
A multi-ethnic genome-wide association study implicates collagen matrix integrity and cell differentiation pathways in keratoconus |
| title_fullStr |
A multi-ethnic genome-wide association study implicates collagen matrix integrity and cell differentiation pathways in keratoconus |
| title_full_unstemmed |
A multi-ethnic genome-wide association study implicates collagen matrix integrity and cell differentiation pathways in keratoconus |
| title_sort |
multi-ethnic genome-wide association study implicates collagen matrix integrity and cell differentiation pathways in keratoconus |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/6eed77457b784436985e138a87c60544 |
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