MICU1 drives glycolysis and chemoresistance in ovarian cancer

The mitochondrial uniporter MICU1 regulates mitochondrial Ca2+ uptake. Here, the authors show that MICU1 is upregulated in ovarian cancer and confers resistance to cisplatin-induced apoptosis through a Ca2+-mediated regulation of pyruvate dehydrogenase activity that results in increased glycolysis.

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Autores principales:	Prabir K. Chakraborty, Soumyajit Banerjee Mustafi, Xunhao Xiong, Shailendra Kumar Dhar Dwivedi, Vasyl Nesin, Sounik Saha, Min Zhang, Danny Dhanasekaran, Muralidharan Jayaraman, Robert Mannel, Kathleen Moore, Scott McMeekin, Da Yang, Rosemary Zuna, Kai Ding, Leonidas Tsiokas, Resham Bhattacharya, Priyabrata Mukherjee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6eedb1c6824a4f579fb70e3563024a60
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:6eedb1c6824a4f579fb70e3563024a602021-12-02T17:06:14ZMICU1 drives glycolysis and chemoresistance in ovarian cancer10.1038/ncomms146342041-1723https://doaj.org/article/6eedb1c6824a4f579fb70e3563024a602017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms14634https://doaj.org/toc/2041-1723The mitochondrial uniporter MICU1 regulates mitochondrial Ca2+ uptake. Here, the authors show that MICU1 is upregulated in ovarian cancer and confers resistance to cisplatin-induced apoptosis through a Ca2+-mediated regulation of pyruvate dehydrogenase activity that results in increased glycolysis.Prabir K. ChakrabortySoumyajit Banerjee MustafiXunhao XiongShailendra Kumar Dhar DwivediVasyl NesinSounik SahaMin ZhangDanny DhanasekaranMuralidharan JayaramanRobert MannelKathleen MooreScott McMeekinDa YangRosemary ZunaKai DingLeonidas TsiokasResham BhattacharyaPriyabrata MukherjeeNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Prabir K. Chakraborty Soumyajit Banerjee Mustafi Xunhao Xiong Shailendra Kumar Dhar Dwivedi Vasyl Nesin Sounik Saha Min Zhang Danny Dhanasekaran Muralidharan Jayaraman Robert Mannel Kathleen Moore Scott McMeekin Da Yang Rosemary Zuna Kai Ding Leonidas Tsiokas Resham Bhattacharya Priyabrata Mukherjee MICU1 drives glycolysis and chemoresistance in ovarian cancer
description	The mitochondrial uniporter MICU1 regulates mitochondrial Ca2+ uptake. Here, the authors show that MICU1 is upregulated in ovarian cancer and confers resistance to cisplatin-induced apoptosis through a Ca2+-mediated regulation of pyruvate dehydrogenase activity that results in increased glycolysis.
format	article
author	Prabir K. Chakraborty Soumyajit Banerjee Mustafi Xunhao Xiong Shailendra Kumar Dhar Dwivedi Vasyl Nesin Sounik Saha Min Zhang Danny Dhanasekaran Muralidharan Jayaraman Robert Mannel Kathleen Moore Scott McMeekin Da Yang Rosemary Zuna Kai Ding Leonidas Tsiokas Resham Bhattacharya Priyabrata Mukherjee
author_facet	Prabir K. Chakraborty Soumyajit Banerjee Mustafi Xunhao Xiong Shailendra Kumar Dhar Dwivedi Vasyl Nesin Sounik Saha Min Zhang Danny Dhanasekaran Muralidharan Jayaraman Robert Mannel Kathleen Moore Scott McMeekin Da Yang Rosemary Zuna Kai Ding Leonidas Tsiokas Resham Bhattacharya Priyabrata Mukherjee
author_sort	Prabir K. Chakraborty
title	MICU1 drives glycolysis and chemoresistance in ovarian cancer
title_short	MICU1 drives glycolysis and chemoresistance in ovarian cancer
title_full	MICU1 drives glycolysis and chemoresistance in ovarian cancer
title_fullStr	MICU1 drives glycolysis and chemoresistance in ovarian cancer
title_full_unstemmed	MICU1 drives glycolysis and chemoresistance in ovarian cancer
title_sort	micu1 drives glycolysis and chemoresistance in ovarian cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6eedb1c6824a4f579fb70e3563024a60
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MICU1 drives glycolysis and chemoresistance in ovarian cancer

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