Development of transgenic cloned pig models of skin inflammation by DNA transposon-directed ectopic expression of human β1 and α2 integrin.

Development of transgenic cloned pig models of skin inflammation by DNA transposon-directed ectopic expression of human β1 and α2 integrin.

Integrins constitute a superfamily of transmembrane signaling receptors that play pivotal roles in cutaneous homeostasis by modulating cell growth and differentiation as well as inflammatory responses in the skin. Subrabasal expression of integrins α2 and/or β1 entails hyperproliferation and aberran...

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Autores principales: Nicklas Heine Staunstrup, Johannes Madsen, Maria Nascimento Primo, Juan Li, Ying Liu, Peter M Kragh, Rong Li, Mette Schmidt, Stig Purup, Frederik Dagnæs-Hansen, Lars Svensson, Thomas K Petersen, Henrik Callesen, Lars Bolund, Jacob Giehm Mikkelsen
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/6eef74c9e6f940338f9d718b1d57f791
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