Prostate cancer evolution from multilineage primary to single lineage metastases with implications for liquid biopsy

Prostate cancer evolution from multilineage primary to single lineage metastases with implications for liquid biopsy

The evolutionary progression from primary to metastatic prostate cancer is largely uncharted, and the implications for liquid biopsy are unexplored. Here, the authors use deep genomic sequencing and histopathological information to trace tumor evolution both within the prostate and during metastasis...

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Autores principales: D. J. Woodcock, E. Riabchenko, S. Taavitsainen, M. Kankainen, G. Gundem, D. S. Brewer, P. Ellonen, M. Lepistö, Y. A. Golubeva, A. C. Warner, T. Tolonen, J. Jasu, W. B. Isaacs, M. R. Emmert-Buck, M. Nykter, T. Visakorpi, G. S. Bova, D. C. Wedge
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/6ef5ee7977814b898210580b5f7363d6
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spelling oai:doaj.org-article:6ef5ee7977814b898210580b5f7363d62021-12-02T19:16:24ZProstate cancer evolution from multilineage primary to single lineage metastases with implications for liquid biopsy10.1038/s41467-020-18843-52041-1723https://doaj.org/article/6ef5ee7977814b898210580b5f7363d62020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18843-5https://doaj.org/toc/2041-1723The evolutionary progression from primary to metastatic prostate cancer is largely uncharted, and the implications for liquid biopsy are unexplored. Here, the authors use deep genomic sequencing and histopathological information to trace tumor evolution both within the prostate and during metastasis in ten men.D. J. WoodcockE. RiabchenkoS. TaavitsainenM. KankainenG. GundemD. S. BrewerP. EllonenM. LepistöY. A. GolubevaA. C. WarnerT. TolonenJ. JasuW. B. IsaacsM. R. Emmert-BuckM. NykterT. VisakorpiG. S. BovaD. C. WedgeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
D. J. Woodcock
E. Riabchenko
S. Taavitsainen
M. Kankainen
G. Gundem
D. S. Brewer
P. Ellonen
M. Lepistö
Y. A. Golubeva
A. C. Warner
T. Tolonen
J. Jasu
W. B. Isaacs
M. R. Emmert-Buck
M. Nykter
T. Visakorpi
G. S. Bova
D. C. Wedge
Prostate cancer evolution from multilineage primary to single lineage metastases with implications for liquid biopsy
description The evolutionary progression from primary to metastatic prostate cancer is largely uncharted, and the implications for liquid biopsy are unexplored. Here, the authors use deep genomic sequencing and histopathological information to trace tumor evolution both within the prostate and during metastasis in ten men.
format article
author D. J. Woodcock
E. Riabchenko
S. Taavitsainen
M. Kankainen
G. Gundem
D. S. Brewer
P. Ellonen
M. Lepistö
Y. A. Golubeva
A. C. Warner
T. Tolonen
J. Jasu
W. B. Isaacs
M. R. Emmert-Buck
M. Nykter
T. Visakorpi
G. S. Bova
D. C. Wedge
author_facet D. J. Woodcock
E. Riabchenko
S. Taavitsainen
M. Kankainen
G. Gundem
D. S. Brewer
P. Ellonen
M. Lepistö
Y. A. Golubeva
A. C. Warner
T. Tolonen
J. Jasu
W. B. Isaacs
M. R. Emmert-Buck
M. Nykter
T. Visakorpi
G. S. Bova
D. C. Wedge
author_sort D. J. Woodcock
title Prostate cancer evolution from multilineage primary to single lineage metastases with implications for liquid biopsy
title_short Prostate cancer evolution from multilineage primary to single lineage metastases with implications for liquid biopsy
title_full Prostate cancer evolution from multilineage primary to single lineage metastases with implications for liquid biopsy
title_fullStr Prostate cancer evolution from multilineage primary to single lineage metastases with implications for liquid biopsy
title_full_unstemmed Prostate cancer evolution from multilineage primary to single lineage metastases with implications for liquid biopsy
title_sort prostate cancer evolution from multilineage primary to single lineage metastases with implications for liquid biopsy
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/6ef5ee7977814b898210580b5f7363d6
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