Adipocyte STAT5 deficiency does not affect blood glucose homeostasis in obese mice.
The aim of this study was to investigate whether the lack of signal transducer and activator of transcription 5 (STAT5) in mature adipocytes of obese mice (Stat5Adipoq mice) improves glucose and lipid metabolism as previously observed in lean mice. Male Stat5Adipoq mice and their wild type (WT) litt...
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Public Library of Science (PLoS)
2021
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oai:doaj.org-article:6ef97d072bda445591f58230afa4de452021-12-02T20:16:07ZAdipocyte STAT5 deficiency does not affect blood glucose homeostasis in obese mice.1932-620310.1371/journal.pone.0260501https://doaj.org/article/6ef97d072bda445591f58230afa4de452021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0260501https://doaj.org/toc/1932-6203The aim of this study was to investigate whether the lack of signal transducer and activator of transcription 5 (STAT5) in mature adipocytes of obese mice (Stat5Adipoq mice) improves glucose and lipid metabolism as previously observed in lean mice. Male Stat5Adipoq mice and their wild type (WT) littermates were fed high-fat diet (HFD). Effects of adipocyte STAT5 deficiency on adiposity as well as on glucose and lipid metabolism were determined under ad libitum feeding and after weight loss induced by calorie restriction. Compared to WT mice, obese Stat5Adipoq mice showed modestly accelerated weight gain and blunted depletion of fat stores under calorie restriction (reduction in % body fat after 3 weeks: WT, -9.3±1.1, vs Stat5Adipoq, -5.9±0.8, p = 0.04). No differences were observed between Stat5Adipoq and WT mice with regard to parameters of glucose and lipid metabolism including basal glycaemia, glucose tolerance, and plasma triglycerides. In conclusion, STAT5 deficiency in the adipocyte of HFD-fed obese mice was associated with increased fat accumulation. In contrast to previous findings in lean mice, however, lipid accumulation was not associated with any improvement in glucose and lipid metabolism. Our results do not support adipocyte STAT5 as a promising target for the treatment of obesity-associated metabolic derangements.Marianna BeghiniTheresia WagnerAndreea Corina LucaMatthäus MetzDoris KalteneckerKatrin SpirkMartina Theresa HacklJohannes HaybaeckRichard MorigglAlexandra Kautzky-WillerThomas SchererClemens FürnsinnPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0260501 (2021) |
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Medicine R Science Q |
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Medicine R Science Q Marianna Beghini Theresia Wagner Andreea Corina Luca Matthäus Metz Doris Kaltenecker Katrin Spirk Martina Theresa Hackl Johannes Haybaeck Richard Moriggl Alexandra Kautzky-Willer Thomas Scherer Clemens Fürnsinn Adipocyte STAT5 deficiency does not affect blood glucose homeostasis in obese mice. |
| description |
The aim of this study was to investigate whether the lack of signal transducer and activator of transcription 5 (STAT5) in mature adipocytes of obese mice (Stat5Adipoq mice) improves glucose and lipid metabolism as previously observed in lean mice. Male Stat5Adipoq mice and their wild type (WT) littermates were fed high-fat diet (HFD). Effects of adipocyte STAT5 deficiency on adiposity as well as on glucose and lipid metabolism were determined under ad libitum feeding and after weight loss induced by calorie restriction. Compared to WT mice, obese Stat5Adipoq mice showed modestly accelerated weight gain and blunted depletion of fat stores under calorie restriction (reduction in % body fat after 3 weeks: WT, -9.3±1.1, vs Stat5Adipoq, -5.9±0.8, p = 0.04). No differences were observed between Stat5Adipoq and WT mice with regard to parameters of glucose and lipid metabolism including basal glycaemia, glucose tolerance, and plasma triglycerides. In conclusion, STAT5 deficiency in the adipocyte of HFD-fed obese mice was associated with increased fat accumulation. In contrast to previous findings in lean mice, however, lipid accumulation was not associated with any improvement in glucose and lipid metabolism. Our results do not support adipocyte STAT5 as a promising target for the treatment of obesity-associated metabolic derangements. |
| format |
article |
| author |
Marianna Beghini Theresia Wagner Andreea Corina Luca Matthäus Metz Doris Kaltenecker Katrin Spirk Martina Theresa Hackl Johannes Haybaeck Richard Moriggl Alexandra Kautzky-Willer Thomas Scherer Clemens Fürnsinn |
| author_facet |
Marianna Beghini Theresia Wagner Andreea Corina Luca Matthäus Metz Doris Kaltenecker Katrin Spirk Martina Theresa Hackl Johannes Haybaeck Richard Moriggl Alexandra Kautzky-Willer Thomas Scherer Clemens Fürnsinn |
| author_sort |
Marianna Beghini |
| title |
Adipocyte STAT5 deficiency does not affect blood glucose homeostasis in obese mice. |
| title_short |
Adipocyte STAT5 deficiency does not affect blood glucose homeostasis in obese mice. |
| title_full |
Adipocyte STAT5 deficiency does not affect blood glucose homeostasis in obese mice. |
| title_fullStr |
Adipocyte STAT5 deficiency does not affect blood glucose homeostasis in obese mice. |
| title_full_unstemmed |
Adipocyte STAT5 deficiency does not affect blood glucose homeostasis in obese mice. |
| title_sort |
adipocyte stat5 deficiency does not affect blood glucose homeostasis in obese mice. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2021 |
| url |
https://doaj.org/article/6ef97d072bda445591f58230afa4de45 |
| work_keys_str_mv |
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