Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps

Proton pumping of mitochondrial complex I depends on the reduction of ubiquinone but the molecular mechanism of energy conversion is unclear. Here, the authors provide structural and biochemical evidence showing that movement of loop TMH1-2 in complex I subunit ND3 is required to drive proton pumpin...

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Autores principales:	Alfredo Cabrera-Orefice, Etienne Galemou Yoga, Christophe Wirth, Karin Siegmund, Klaus Zwicker, Sergio Guerrero-Castillo, Volker Zickermann, Carola Hunte, Ulrich Brandt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6efa54739f774befb5b738b28df7f4b2
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spelling	oai:doaj.org-article:6efa54739f774befb5b738b28df7f4b22021-12-02T14:39:24ZLocking loop movement in the ubiquinone pocket of complex I disengages the proton pumps10.1038/s41467-018-06955-y2041-1723https://doaj.org/article/6efa54739f774befb5b738b28df7f4b22018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06955-yhttps://doaj.org/toc/2041-1723Proton pumping of mitochondrial complex I depends on the reduction of ubiquinone but the molecular mechanism of energy conversion is unclear. Here, the authors provide structural and biochemical evidence showing that movement of loop TMH1-2 in complex I subunit ND3 is required to drive proton pumping.Alfredo Cabrera-OreficeEtienne Galemou YogaChristophe WirthKarin SiegmundKlaus ZwickerSergio Guerrero-CastilloVolker ZickermannCarola HunteUlrich BrandtNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alfredo Cabrera-Orefice Etienne Galemou Yoga Christophe Wirth Karin Siegmund Klaus Zwicker Sergio Guerrero-Castillo Volker Zickermann Carola Hunte Ulrich Brandt Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps
description	Proton pumping of mitochondrial complex I depends on the reduction of ubiquinone but the molecular mechanism of energy conversion is unclear. Here, the authors provide structural and biochemical evidence showing that movement of loop TMH1-2 in complex I subunit ND3 is required to drive proton pumping.
format	article
author	Alfredo Cabrera-Orefice Etienne Galemou Yoga Christophe Wirth Karin Siegmund Klaus Zwicker Sergio Guerrero-Castillo Volker Zickermann Carola Hunte Ulrich Brandt
author_facet	Alfredo Cabrera-Orefice Etienne Galemou Yoga Christophe Wirth Karin Siegmund Klaus Zwicker Sergio Guerrero-Castillo Volker Zickermann Carola Hunte Ulrich Brandt
author_sort	Alfredo Cabrera-Orefice
title	Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps
title_short	Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps
title_full	Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps
title_fullStr	Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps
title_full_unstemmed	Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps
title_sort	locking loop movement in the ubiquinone pocket of complex i disengages the proton pumps
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/6efa54739f774befb5b738b28df7f4b2
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Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps

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