Amalgamation of complex iron(III) ions and iron nanoclusters with MWCNTs as a route to potential T2 MRI contrast agents

Nikodem Kuźnik,1 Mateusz M Tomczyk,1 Marzena Wyskocka,1 Łukasz Przypis,1 Artur P Herman,1 Rafał Jędrysiak,1 Krzysztof K Koziol,2 Slawomir Boncel11Department of Organic Chemistry, Bioorganic Chemistry and Biotechnology, Faculty of Chemistry, Silesian University of Technology, Gliwice, Poland; 2Depart...

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Autores principales:	Kuźnik N, Tomczyk MM, Wyskocka M, Przypis L, Herman AP, Jędrysiak R, Koziol KK, Boncel S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6efdf6dd8a4d4bffbd7d6af4ce116ac6
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spelling	oai:doaj.org-article:6efdf6dd8a4d4bffbd7d6af4ce116ac62021-12-02T01:34:51ZAmalgamation of complex iron(III) ions and iron nanoclusters with MWCNTs as a route to potential T2 MRI contrast agents1178-2013https://doaj.org/article/6efdf6dd8a4d4bffbd7d6af4ce116ac62015-05-01T00:00:00Zhttp://www.dovepress.com/amalgamation-of-complex-ironiii-ions-and-iron-nanoclusters-with-mwcnts-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Nikodem Kuźnik,1 Mateusz M Tomczyk,1 Marzena Wyskocka,1 Łukasz Przypis,1 Artur P Herman,1 Rafał Jędrysiak,1 Krzysztof K Koziol,2 Slawomir Boncel11Department of Organic Chemistry, Bioorganic Chemistry and Biotechnology, Faculty of Chemistry, Silesian University of Technology, Gliwice, Poland; 2Department of Materials Science and Metallurgy, University of Cambridge, Cambridge, UKAbstract: Iron-filled multiwall carbon nanotubes (Fe@MWCNTs) were functionalized toward a variety of potential magnetic resonance imaging contrast agents. Oxidized Fe@MWNCTs were covered with PEG5000 via direct esterification or using acyl chloride derivatives. Alternatively, the latter were functionalized with an aminophenol ligand (Fe@O-MWCNT-L). Moreover, pristine Fe@MWCNTs were functionalized with N-phenylaziridine groups (Fe@f-MWCNT) via [2+1] cycloaddition of nitrene. All of these chemically modified nanotubes served as a vehicle for anchoring Fe3+ ions. The new hybrids – Fe(III)/Fe@(f-/O-)MWCNTs – containing 6%–14% of the “tethered” Fe3+ ions were studied in terms of the acceleration of relaxation of water protons in nuclear magnetic resonance. The highest transverse relaxivity r2=63.9±0.9 mL mg-1 s-1 was recorded for Fe(III)/Fe@O-MWCNT-L, while for Fe(III)/Fe@f-MWCNT, with r2=57.9±2.9 mL mg-1 s-1, the highest impact of the anchored Fe(III) ions was observed. The T1/T2 ratio of 30–100 found for all of the nanotube hybrids presented in this work is a very important factor for their potential application as T2 contrast agents. Increased stability of the hybrids was confirmed by ultraviolet–visible spectrophotometry.Keywords: multiwall carbon nanotubes, Fe3+, transverse relaxation time T2, MRI contrast agentKuźnik NTomczyk MMWyskocka MPrzypis LHerman APJędrysiak RKoziol KKBoncel SDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 3581-3591 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Kuźnik N Tomczyk MM Wyskocka M Przypis L Herman AP Jędrysiak R Koziol KK Boncel S Amalgamation of complex iron(III) ions and iron nanoclusters with MWCNTs as a route to potential T2 MRI contrast agents
description	Nikodem Kuźnik,1 Mateusz M Tomczyk,1 Marzena Wyskocka,1 Łukasz Przypis,1 Artur P Herman,1 Rafał Jędrysiak,1 Krzysztof K Koziol,2 Slawomir Boncel11Department of Organic Chemistry, Bioorganic Chemistry and Biotechnology, Faculty of Chemistry, Silesian University of Technology, Gliwice, Poland; 2Department of Materials Science and Metallurgy, University of Cambridge, Cambridge, UKAbstract: Iron-filled multiwall carbon nanotubes (Fe@MWCNTs) were functionalized toward a variety of potential magnetic resonance imaging contrast agents. Oxidized Fe@MWNCTs were covered with PEG5000 via direct esterification or using acyl chloride derivatives. Alternatively, the latter were functionalized with an aminophenol ligand (Fe@O-MWCNT-L). Moreover, pristine Fe@MWCNTs were functionalized with N-phenylaziridine groups (Fe@f-MWCNT) via [2+1] cycloaddition of nitrene. All of these chemically modified nanotubes served as a vehicle for anchoring Fe3+ ions. The new hybrids – Fe(III)/Fe@(f-/O-)MWCNTs – containing 6%–14% of the “tethered” Fe3+ ions were studied in terms of the acceleration of relaxation of water protons in nuclear magnetic resonance. The highest transverse relaxivity r2=63.9±0.9 mL mg-1 s-1 was recorded for Fe(III)/Fe@O-MWCNT-L, while for Fe(III)/Fe@f-MWCNT, with r2=57.9±2.9 mL mg-1 s-1, the highest impact of the anchored Fe(III) ions was observed. The T1/T2 ratio of 30–100 found for all of the nanotube hybrids presented in this work is a very important factor for their potential application as T2 contrast agents. Increased stability of the hybrids was confirmed by ultraviolet–visible spectrophotometry.Keywords: multiwall carbon nanotubes, Fe3+, transverse relaxation time T2, MRI contrast agent
format	article
author	Kuźnik N Tomczyk MM Wyskocka M Przypis L Herman AP Jędrysiak R Koziol KK Boncel S
author_facet	Kuźnik N Tomczyk MM Wyskocka M Przypis L Herman AP Jędrysiak R Koziol KK Boncel S
author_sort	Kuźnik N
title	Amalgamation of complex iron(III) ions and iron nanoclusters with MWCNTs as a route to potential T2 MRI contrast agents
title_short	Amalgamation of complex iron(III) ions and iron nanoclusters with MWCNTs as a route to potential T2 MRI contrast agents
title_full	Amalgamation of complex iron(III) ions and iron nanoclusters with MWCNTs as a route to potential T2 MRI contrast agents
title_fullStr	Amalgamation of complex iron(III) ions and iron nanoclusters with MWCNTs as a route to potential T2 MRI contrast agents
title_full_unstemmed	Amalgamation of complex iron(III) ions and iron nanoclusters with MWCNTs as a route to potential T2 MRI contrast agents
title_sort	amalgamation of complex iron(iii) ions and iron nanoclusters with mwcnts as a route to potential t2 mri contrast agents
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/6efdf6dd8a4d4bffbd7d6af4ce116ac6
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Amalgamation of complex iron(III) ions and iron nanoclusters with MWCNTs as a route to potential T2 MRI contrast agents

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