Evaluation of the association between periodontitis and risk of Parkinson’s disease: a nationwide retrospective cohort study

Abstract The objective of this study was to examine the association between periodontitis and risk of incident Parkinson’s disease using large-scale cohort data on the entire population of South Korea. Health checkup data from 6,856,180 participants aged 40 and older were provided by the National He...

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Autores principales:	Eunkyung Jeong, Jun-Beom Park, Yong-Gyu Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6eff41e2031244dabbcb1933a3e7b5cf
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spelling	oai:doaj.org-article:6eff41e2031244dabbcb1933a3e7b5cf2021-12-02T16:45:41ZEvaluation of the association between periodontitis and risk of Parkinson’s disease: a nationwide retrospective cohort study10.1038/s41598-021-96147-42045-2322https://doaj.org/article/6eff41e2031244dabbcb1933a3e7b5cf2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96147-4https://doaj.org/toc/2045-2322Abstract The objective of this study was to examine the association between periodontitis and risk of incident Parkinson’s disease using large-scale cohort data on the entire population of South Korea. Health checkup data from 6,856,180 participants aged 40 and older were provided by the National Health Insurance Service of South Korea between January 1, 2009, and December 31, 2009, and the data were followed until December 31, 2017. The hazard ratio (HR) of Parkinson’s disease and 95% confidence interval (CI) were estimated using a Cox proportional hazards model adjusted for potential confounders. The incidence probability of Parkinson’s disease was positively correlated with the presence of periodontitis. The HR of Parkinson’s disease for the participants without the need of further dentist visits was 0.96 (95% CI 0.921–1.002); the HR of Parkinson’s disease increased to 1.142 (95% CI 1.094–1.193) for the individuals who needed further dentist visits. Compared to individuals without periodontitis and without metabolic syndrome, the HR of incident Parkinson’s disease gradually increased for individuals with periodontitis, with metabolic syndrome, and with both periodontitis and metabolic syndrome. People with periodontitis and metabolic syndrome had the highest HR of incident Parkinson’s disease, at 1.167 (95% CI 1.118–1.219). In conclusion, a weak association between periodontitis and Parkinson’s disease was suggested after adjusting for confounding factors from the population-based large-scale cohort of the entire South Korean population.Eunkyung JeongJun-Beom ParkYong-Gyu ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eunkyung Jeong Jun-Beom Park Yong-Gyu Park Evaluation of the association between periodontitis and risk of Parkinson’s disease: a nationwide retrospective cohort study
description	Abstract The objective of this study was to examine the association between periodontitis and risk of incident Parkinson’s disease using large-scale cohort data on the entire population of South Korea. Health checkup data from 6,856,180 participants aged 40 and older were provided by the National Health Insurance Service of South Korea between January 1, 2009, and December 31, 2009, and the data were followed until December 31, 2017. The hazard ratio (HR) of Parkinson’s disease and 95% confidence interval (CI) were estimated using a Cox proportional hazards model adjusted for potential confounders. The incidence probability of Parkinson’s disease was positively correlated with the presence of periodontitis. The HR of Parkinson’s disease for the participants without the need of further dentist visits was 0.96 (95% CI 0.921–1.002); the HR of Parkinson’s disease increased to 1.142 (95% CI 1.094–1.193) for the individuals who needed further dentist visits. Compared to individuals without periodontitis and without metabolic syndrome, the HR of incident Parkinson’s disease gradually increased for individuals with periodontitis, with metabolic syndrome, and with both periodontitis and metabolic syndrome. People with periodontitis and metabolic syndrome had the highest HR of incident Parkinson’s disease, at 1.167 (95% CI 1.118–1.219). In conclusion, a weak association between periodontitis and Parkinson’s disease was suggested after adjusting for confounding factors from the population-based large-scale cohort of the entire South Korean population.
format	article
author	Eunkyung Jeong Jun-Beom Park Yong-Gyu Park
author_facet	Eunkyung Jeong Jun-Beom Park Yong-Gyu Park
author_sort	Eunkyung Jeong
title	Evaluation of the association between periodontitis and risk of Parkinson’s disease: a nationwide retrospective cohort study
title_short	Evaluation of the association between periodontitis and risk of Parkinson’s disease: a nationwide retrospective cohort study
title_full	Evaluation of the association between periodontitis and risk of Parkinson’s disease: a nationwide retrospective cohort study
title_fullStr	Evaluation of the association between periodontitis and risk of Parkinson’s disease: a nationwide retrospective cohort study
title_full_unstemmed	Evaluation of the association between periodontitis and risk of Parkinson’s disease: a nationwide retrospective cohort study
title_sort	evaluation of the association between periodontitis and risk of parkinson’s disease: a nationwide retrospective cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6eff41e2031244dabbcb1933a3e7b5cf
work_keys_str_mv	AT eunkyungjeong evaluationoftheassociationbetweenperiodontitisandriskofparkinsonsdiseaseanationwideretrospectivecohortstudy AT junbeompark evaluationoftheassociationbetweenperiodontitisandriskofparkinsonsdiseaseanationwideretrospectivecohortstudy AT yonggyupark evaluationoftheassociationbetweenperiodontitisandriskofparkinsonsdiseaseanationwideretrospectivecohortstudy
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Evaluation of the association between periodontitis and risk of Parkinson’s disease: a nationwide retrospective cohort study

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