Towards optimising experimental quantification of persistent pain in Parkinson’s disease using psychophysical testing

Abstract People with Parkinson’s disease (PD) may live for multiple decades after diagnosis. Ensuring that effective healthcare provision is received across the range of symptoms experienced is vital to the individual’s wellbeing and quality of life. As well as the hallmark motor symptoms, PD patien...

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Autores principales:	Kirsty Bannister, Rory V. Smith, Patrick Wilkins, Tatum M. Cummins
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/6eff7ffbf1af4eb28ddb9cb7c3b39ea1
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spelling	oai:doaj.org-article:6eff7ffbf1af4eb28ddb9cb7c3b39ea12021-12-02T13:17:43ZTowards optimising experimental quantification of persistent pain in Parkinson’s disease using psychophysical testing10.1038/s41531-021-00173-y2373-8057https://doaj.org/article/6eff7ffbf1af4eb28ddb9cb7c3b39ea12021-03-01T00:00:00Zhttps://doi.org/10.1038/s41531-021-00173-yhttps://doaj.org/toc/2373-8057Abstract People with Parkinson’s disease (PD) may live for multiple decades after diagnosis. Ensuring that effective healthcare provision is received across the range of symptoms experienced is vital to the individual’s wellbeing and quality of life. As well as the hallmark motor symptoms, PD patients may also suffer from non-motor symptoms including persistent pain. This type of pain (lasting more than 3 months) is inconsistently described and poorly understood, resulting in limited treatment options. Evidence-based pain remedies are coming to the fore but therapeutic strategies that offer an improved analgesic profile remain an unmet clinical need. Since the ability to establish a link between the neurodegenerative changes that underlie PD and those that underlie maladaptive pain processing leading to persistent pain could illuminate mechanisms or risk factors of disease initiation, progression and maintenance, we evaluated the latest research literature seeking to identify causal factors underlying persistent pain in PD through experimental quantification. The majority of previous studies aimed to identify neurobiological alterations that could provide a biomarker for pain/pain phenotype, in PD cohorts. However heterogeneity of patient cohorts, result outcomes and methodology between human psychophysics studies overwhelmingly leads to inconclusive and equivocal evidence. Here we discuss refinement of pain-PD paradigms in order that future studies may enhance confidence in the validity of observed effect sizes while also aiding comparability through standardisation. Encouragingly, as the field moves towards cross-study comparison of data in order to more reliably reveal mechanisms underlying dysfunctional pain processing, the potential for better-targeted treatment and management is high.Kirsty BannisterRory V. SmithPatrick WilkinsTatum M. CumminsNature PortfolioarticleNeurology. Diseases of the nervous systemRC346-429ENnpj Parkinson's Disease, Vol 7, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 Kirsty Bannister Rory V. Smith Patrick Wilkins Tatum M. Cummins Towards optimising experimental quantification of persistent pain in Parkinson’s disease using psychophysical testing
description	Abstract People with Parkinson’s disease (PD) may live for multiple decades after diagnosis. Ensuring that effective healthcare provision is received across the range of symptoms experienced is vital to the individual’s wellbeing and quality of life. As well as the hallmark motor symptoms, PD patients may also suffer from non-motor symptoms including persistent pain. This type of pain (lasting more than 3 months) is inconsistently described and poorly understood, resulting in limited treatment options. Evidence-based pain remedies are coming to the fore but therapeutic strategies that offer an improved analgesic profile remain an unmet clinical need. Since the ability to establish a link between the neurodegenerative changes that underlie PD and those that underlie maladaptive pain processing leading to persistent pain could illuminate mechanisms or risk factors of disease initiation, progression and maintenance, we evaluated the latest research literature seeking to identify causal factors underlying persistent pain in PD through experimental quantification. The majority of previous studies aimed to identify neurobiological alterations that could provide a biomarker for pain/pain phenotype, in PD cohorts. However heterogeneity of patient cohorts, result outcomes and methodology between human psychophysics studies overwhelmingly leads to inconclusive and equivocal evidence. Here we discuss refinement of pain-PD paradigms in order that future studies may enhance confidence in the validity of observed effect sizes while also aiding comparability through standardisation. Encouragingly, as the field moves towards cross-study comparison of data in order to more reliably reveal mechanisms underlying dysfunctional pain processing, the potential for better-targeted treatment and management is high.
format	article
author	Kirsty Bannister Rory V. Smith Patrick Wilkins Tatum M. Cummins
author_facet	Kirsty Bannister Rory V. Smith Patrick Wilkins Tatum M. Cummins
author_sort	Kirsty Bannister
title	Towards optimising experimental quantification of persistent pain in Parkinson’s disease using psychophysical testing
title_short	Towards optimising experimental quantification of persistent pain in Parkinson’s disease using psychophysical testing
title_full	Towards optimising experimental quantification of persistent pain in Parkinson’s disease using psychophysical testing
title_fullStr	Towards optimising experimental quantification of persistent pain in Parkinson’s disease using psychophysical testing
title_full_unstemmed	Towards optimising experimental quantification of persistent pain in Parkinson’s disease using psychophysical testing
title_sort	towards optimising experimental quantification of persistent pain in parkinson’s disease using psychophysical testing
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6eff7ffbf1af4eb28ddb9cb7c3b39ea1
work_keys_str_mv	AT kirstybannister towardsoptimisingexperimentalquantificationofpersistentpaininparkinsonsdiseaseusingpsychophysicaltesting AT roryvsmith towardsoptimisingexperimentalquantificationofpersistentpaininparkinsonsdiseaseusingpsychophysicaltesting AT patrickwilkins towardsoptimisingexperimentalquantificationofpersistentpaininparkinsonsdiseaseusingpsychophysicaltesting AT tatummcummins towardsoptimisingexperimentalquantificationofpersistentpaininparkinsonsdiseaseusingpsychophysicaltesting
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Towards optimising experimental quantification of persistent pain in Parkinson’s disease using psychophysical testing

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