PCP and Wnt pathway components act in parallel during zebrafish mechanosensory hair cell orientation

Planar cell polarity (PCP) regulates hair cell orientation in the zebrafish lateral line. Here, the authors show that mutating Wnt pathway genes (wnt11f1, fzd7a/b, and gpc4) causes concentric hair cell patterns not regulated by PCP, thus showing PCP/Wnt pathway genes have different consequences on h...

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Autores principales:	Joaquin Navajas Acedo, Matthew G. Voas, Richard Alexander, Thomas Woolley, Jay R. Unruh, Hua Li, Cecilia Moens, Tatjana Piotrowski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6f012fa95fe24ae2a2db36aed2fcdecd
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spelling	oai:doaj.org-article:6f012fa95fe24ae2a2db36aed2fcdecd2021-12-02T17:01:38ZPCP and Wnt pathway components act in parallel during zebrafish mechanosensory hair cell orientation10.1038/s41467-019-12005-y2041-1723https://doaj.org/article/6f012fa95fe24ae2a2db36aed2fcdecd2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12005-yhttps://doaj.org/toc/2041-1723Planar cell polarity (PCP) regulates hair cell orientation in the zebrafish lateral line. Here, the authors show that mutating Wnt pathway genes (wnt11f1, fzd7a/b, and gpc4) causes concentric hair cell patterns not regulated by PCP, thus showing PCP/Wnt pathway genes have different consequences on hair cell orientation.Joaquin Navajas AcedoMatthew G. VoasRichard AlexanderThomas WoolleyJay R. UnruhHua LiCecilia MoensTatjana PiotrowskiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joaquin Navajas Acedo Matthew G. Voas Richard Alexander Thomas Woolley Jay R. Unruh Hua Li Cecilia Moens Tatjana Piotrowski PCP and Wnt pathway components act in parallel during zebrafish mechanosensory hair cell orientation
description	Planar cell polarity (PCP) regulates hair cell orientation in the zebrafish lateral line. Here, the authors show that mutating Wnt pathway genes (wnt11f1, fzd7a/b, and gpc4) causes concentric hair cell patterns not regulated by PCP, thus showing PCP/Wnt pathway genes have different consequences on hair cell orientation.
format	article
author	Joaquin Navajas Acedo Matthew G. Voas Richard Alexander Thomas Woolley Jay R. Unruh Hua Li Cecilia Moens Tatjana Piotrowski
author_facet	Joaquin Navajas Acedo Matthew G. Voas Richard Alexander Thomas Woolley Jay R. Unruh Hua Li Cecilia Moens Tatjana Piotrowski
author_sort	Joaquin Navajas Acedo
title	PCP and Wnt pathway components act in parallel during zebrafish mechanosensory hair cell orientation
title_short	PCP and Wnt pathway components act in parallel during zebrafish mechanosensory hair cell orientation
title_full	PCP and Wnt pathway components act in parallel during zebrafish mechanosensory hair cell orientation
title_fullStr	PCP and Wnt pathway components act in parallel during zebrafish mechanosensory hair cell orientation
title_full_unstemmed	PCP and Wnt pathway components act in parallel during zebrafish mechanosensory hair cell orientation
title_sort	pcp and wnt pathway components act in parallel during zebrafish mechanosensory hair cell orientation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6f012fa95fe24ae2a2db36aed2fcdecd
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PCP and Wnt pathway components act in parallel during zebrafish mechanosensory hair cell orientation

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