Intrabody Targeting HIF-1α Mediates Transcriptional Downregulation of Target Genes Related to Solid Tumors

Uncontrolled growth of solid tumors will result in a hallmark hypoxic condition, whereby the key transcriptional regulator of hypoxia inducible factor-1α (HIF-1α) will be stabilized to activate the transcription of target genes that are responsible for the metabolism, proliferation, and metastasis o...

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Autores principales: Yaozhong Hu, Ema Romão, Cécile Vincke, Lea Brys, Yvon Elkrim, Marylène Vandevenne, Changxiao Liu, Serge Muyldermans
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
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Acceso en línea:https://doaj.org/article/6f0151a9c47f46fca5f4ada2110b62ff
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