Crystal structure of glycogen debranching enzyme and insights into its catalysis and disease-causing mutations

Debranching of glycogen is an important step in its use as an energy source. Here, the authors describe the crystal structures of glycogen debranching enzyme alone and in complex with oligosaccharides and provide molecular insights into the function, and into associated diseases.

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Autores principales:	Liting Zhai, Lingling Feng, Lin Xia, Huiyong Yin, Song Xiang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6f02788bb1894b07b2fa0be196a97505
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spelling	oai:doaj.org-article:6f02788bb1894b07b2fa0be196a975052021-12-02T14:39:35ZCrystal structure of glycogen debranching enzyme and insights into its catalysis and disease-causing mutations10.1038/ncomms112292041-1723https://doaj.org/article/6f02788bb1894b07b2fa0be196a975052016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11229https://doaj.org/toc/2041-1723Debranching of glycogen is an important step in its use as an energy source. Here, the authors describe the crystal structures of glycogen debranching enzyme alone and in complex with oligosaccharides and provide molecular insights into the function, and into associated diseases.Liting ZhaiLingling FengLin XiaHuiyong YinSong XiangNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Liting Zhai Lingling Feng Lin Xia Huiyong Yin Song Xiang Crystal structure of glycogen debranching enzyme and insights into its catalysis and disease-causing mutations
description	Debranching of glycogen is an important step in its use as an energy source. Here, the authors describe the crystal structures of glycogen debranching enzyme alone and in complex with oligosaccharides and provide molecular insights into the function, and into associated diseases.
format	article
author	Liting Zhai Lingling Feng Lin Xia Huiyong Yin Song Xiang
author_facet	Liting Zhai Lingling Feng Lin Xia Huiyong Yin Song Xiang
author_sort	Liting Zhai
title	Crystal structure of glycogen debranching enzyme and insights into its catalysis and disease-causing mutations
title_short	Crystal structure of glycogen debranching enzyme and insights into its catalysis and disease-causing mutations
title_full	Crystal structure of glycogen debranching enzyme and insights into its catalysis and disease-causing mutations
title_fullStr	Crystal structure of glycogen debranching enzyme and insights into its catalysis and disease-causing mutations
title_full_unstemmed	Crystal structure of glycogen debranching enzyme and insights into its catalysis and disease-causing mutations
title_sort	crystal structure of glycogen debranching enzyme and insights into its catalysis and disease-causing mutations
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/6f02788bb1894b07b2fa0be196a97505
work_keys_str_mv	AT litingzhai crystalstructureofglycogendebranchingenzymeandinsightsintoitscatalysisanddiseasecausingmutations AT linglingfeng crystalstructureofglycogendebranchingenzymeandinsightsintoitscatalysisanddiseasecausingmutations AT linxia crystalstructureofglycogendebranchingenzymeandinsightsintoitscatalysisanddiseasecausingmutations AT huiyongyin crystalstructureofglycogendebranchingenzymeandinsightsintoitscatalysisanddiseasecausingmutations AT songxiang crystalstructureofglycogendebranchingenzymeandinsightsintoitscatalysisanddiseasecausingmutations
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Crystal structure of glycogen debranching enzyme and insights into its catalysis and disease-causing mutations

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