Associations of Serum Resistin With the Severity and Prognosis in Patients With Community-Acquired Pneumonia

BackgroundResistin is an endogenous ligand of Toll-like receptor 4 that activates several inflammatory signals. But the physiological function of resistin in community-acquired pneumonia (CAP) remains unknown. The goal of this research was to explore the associations between serum resistin and the s...

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Autores principales:	Chun-Mei Feng, Jia-Yi Cheng, Zheng Xu, Hong-Yan Liu, De-Xiang Xu, Lin Fu, Hui Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	resistin community-acquired pneumonia inflammatory cytokines severity prognosis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/6f042c60dc9143579481fa9eac84d346
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spelling	oai:doaj.org-article:6f042c60dc9143579481fa9eac84d3462021-11-09T06:39:05ZAssociations of Serum Resistin With the Severity and Prognosis in Patients With Community-Acquired Pneumonia1664-322410.3389/fimmu.2021.703515https://doaj.org/article/6f042c60dc9143579481fa9eac84d3462021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.703515/fullhttps://doaj.org/toc/1664-3224BackgroundResistin is an endogenous ligand of Toll-like receptor 4 that activates several inflammatory signals. But the physiological function of resistin in community-acquired pneumonia (CAP) remains unknown. The goal of this research was to explore the associations between serum resistin and the severity and prognosis in CAP patients through a retrospective cohort study.MethodsAll 212 CAP patients and 106 healthy cases were enrolled. Demographic characteristics were extracted. Serum resistin was determined via enzyme-linked immunosorbent assay. The prognosis was tracked in CAP patients.ResultsSerum resistin on admission was raised in CAP patients compared with control cases. The level of resistin was gradually increased in parallel with CAP severity scores in CAP patients. Pearson and Spearman analyses revealed that serum resistin was positively correlated with CAP severity scores, white blood cells, urea nitrogen, creatinine, and inflammatory cytokines among CAP patients. There were negative relationships between resistin and hematocrit and albumin in CAP patients. Besides, linear and logistic regression analyses further indicated that serum resistin on admission was positively associated with CAP severity scores among CAP patients. Follow-up research revealed that serum resistin elevation on admission prolonged hospital stay in CAP patients.ConclusionSerum resistin on admission is positively correlated with the severity and hospital stay in CAP patients, indicating that resistin may be involved in the physiological process of CAP. Serum resistin may be a potential biomarker in the diagnosis and prognosis for CAP.Chun-Mei FengJia-Yi ChengZheng XuHong-Yan LiuDe-Xiang XuLin FuLin FuHui ZhaoFrontiers Media S.A.articleresistincommunity-acquired pneumoniainflammatory cytokinesseverityprognosisImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	resistin community-acquired pneumonia inflammatory cytokines severity prognosis Immunologic diseases. Allergy RC581-607
spellingShingle	resistin community-acquired pneumonia inflammatory cytokines severity prognosis Immunologic diseases. Allergy RC581-607 Chun-Mei Feng Jia-Yi Cheng Zheng Xu Hong-Yan Liu De-Xiang Xu Lin Fu Lin Fu Hui Zhao Associations of Serum Resistin With the Severity and Prognosis in Patients With Community-Acquired Pneumonia
description	BackgroundResistin is an endogenous ligand of Toll-like receptor 4 that activates several inflammatory signals. But the physiological function of resistin in community-acquired pneumonia (CAP) remains unknown. The goal of this research was to explore the associations between serum resistin and the severity and prognosis in CAP patients through a retrospective cohort study.MethodsAll 212 CAP patients and 106 healthy cases were enrolled. Demographic characteristics were extracted. Serum resistin was determined via enzyme-linked immunosorbent assay. The prognosis was tracked in CAP patients.ResultsSerum resistin on admission was raised in CAP patients compared with control cases. The level of resistin was gradually increased in parallel with CAP severity scores in CAP patients. Pearson and Spearman analyses revealed that serum resistin was positively correlated with CAP severity scores, white blood cells, urea nitrogen, creatinine, and inflammatory cytokines among CAP patients. There were negative relationships between resistin and hematocrit and albumin in CAP patients. Besides, linear and logistic regression analyses further indicated that serum resistin on admission was positively associated with CAP severity scores among CAP patients. Follow-up research revealed that serum resistin elevation on admission prolonged hospital stay in CAP patients.ConclusionSerum resistin on admission is positively correlated with the severity and hospital stay in CAP patients, indicating that resistin may be involved in the physiological process of CAP. Serum resistin may be a potential biomarker in the diagnosis and prognosis for CAP.
format	article
author	Chun-Mei Feng Jia-Yi Cheng Zheng Xu Hong-Yan Liu De-Xiang Xu Lin Fu Lin Fu Hui Zhao
author_facet	Chun-Mei Feng Jia-Yi Cheng Zheng Xu Hong-Yan Liu De-Xiang Xu Lin Fu Lin Fu Hui Zhao
author_sort	Chun-Mei Feng
title	Associations of Serum Resistin With the Severity and Prognosis in Patients With Community-Acquired Pneumonia
title_short	Associations of Serum Resistin With the Severity and Prognosis in Patients With Community-Acquired Pneumonia
title_full	Associations of Serum Resistin With the Severity and Prognosis in Patients With Community-Acquired Pneumonia
title_fullStr	Associations of Serum Resistin With the Severity and Prognosis in Patients With Community-Acquired Pneumonia
title_full_unstemmed	Associations of Serum Resistin With the Severity and Prognosis in Patients With Community-Acquired Pneumonia
title_sort	associations of serum resistin with the severity and prognosis in patients with community-acquired pneumonia
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/6f042c60dc9143579481fa9eac84d346
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Associations of Serum Resistin With the Severity and Prognosis in Patients With Community-Acquired Pneumonia

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