Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression

Cyclic GMP-AMP synthase (cGAS) is involved in the modulation of inflammatory responses. Here, the authors present small-molecule inhibitors of human cGAS, characterize their interaction with the protein, and show that the compounds are active in interferon-producing cells including primary human mac...

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Autores principales:	Lodoe Lama, Carolina Adura, Wei Xie, Daisuke Tomita, Taku Kamei, Vitaly Kuryavyi, Tasos Gogakos, Joshua I. Steinberg, Michael Miller, Lavoisier Ramos-Espiritu, Yasutomi Asano, Shogo Hashizume, Jumpei Aida, Toshihiro Imaeda, Rei Okamoto, Andy J. Jennings, Mayako Michino, Takanobu Kuroita, Andrew Stamford, Pu Gao, Peter Meinke, J. Fraser Glickman, Dinshaw J. Patel, Thomas Tuschl
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6f06ae155ca2436dab39b0d693daf384
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spelling	oai:doaj.org-article:6f06ae155ca2436dab39b0d693daf3842021-12-02T16:57:44ZDevelopment of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression10.1038/s41467-019-08620-42041-1723https://doaj.org/article/6f06ae155ca2436dab39b0d693daf3842019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08620-4https://doaj.org/toc/2041-1723Cyclic GMP-AMP synthase (cGAS) is involved in the modulation of inflammatory responses. Here, the authors present small-molecule inhibitors of human cGAS, characterize their interaction with the protein, and show that the compounds are active in interferon-producing cells including primary human macrophages.Lodoe LamaCarolina AduraWei XieDaisuke TomitaTaku KameiVitaly KuryavyiTasos GogakosJoshua I. SteinbergMichael MillerLavoisier Ramos-EspirituYasutomi AsanoShogo HashizumeJumpei AidaToshihiro ImaedaRei OkamotoAndy J. JenningsMayako MichinoTakanobu KuroitaAndrew StamfordPu GaoPeter MeinkeJ. Fraser GlickmanDinshaw J. PatelThomas TuschlNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lodoe Lama Carolina Adura Wei Xie Daisuke Tomita Taku Kamei Vitaly Kuryavyi Tasos Gogakos Joshua I. Steinberg Michael Miller Lavoisier Ramos-Espiritu Yasutomi Asano Shogo Hashizume Jumpei Aida Toshihiro Imaeda Rei Okamoto Andy J. Jennings Mayako Michino Takanobu Kuroita Andrew Stamford Pu Gao Peter Meinke J. Fraser Glickman Dinshaw J. Patel Thomas Tuschl Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression
description	Cyclic GMP-AMP synthase (cGAS) is involved in the modulation of inflammatory responses. Here, the authors present small-molecule inhibitors of human cGAS, characterize their interaction with the protein, and show that the compounds are active in interferon-producing cells including primary human macrophages.
format	article
author	Lodoe Lama Carolina Adura Wei Xie Daisuke Tomita Taku Kamei Vitaly Kuryavyi Tasos Gogakos Joshua I. Steinberg Michael Miller Lavoisier Ramos-Espiritu Yasutomi Asano Shogo Hashizume Jumpei Aida Toshihiro Imaeda Rei Okamoto Andy J. Jennings Mayako Michino Takanobu Kuroita Andrew Stamford Pu Gao Peter Meinke J. Fraser Glickman Dinshaw J. Patel Thomas Tuschl
author_facet	Lodoe Lama Carolina Adura Wei Xie Daisuke Tomita Taku Kamei Vitaly Kuryavyi Tasos Gogakos Joshua I. Steinberg Michael Miller Lavoisier Ramos-Espiritu Yasutomi Asano Shogo Hashizume Jumpei Aida Toshihiro Imaeda Rei Okamoto Andy J. Jennings Mayako Michino Takanobu Kuroita Andrew Stamford Pu Gao Peter Meinke J. Fraser Glickman Dinshaw J. Patel Thomas Tuschl
author_sort	Lodoe Lama
title	Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression
title_short	Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression
title_full	Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression
title_fullStr	Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression
title_full_unstemmed	Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression
title_sort	development of human cgas-specific small-molecule inhibitors for repression of dsdna-triggered interferon expression
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6f06ae155ca2436dab39b0d693daf384
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Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression

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