Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis

Favipiravir (T-705) is an inhibitor of viral RNA-dependent-RNA-polymerases (RdRp) and clinical trials for the treatment of COVID-19 are ongoing. Here, the authors show that SARS-CoV nsp12 is the fastest known viral RdRp and they provide insights into the mechanism of action of Favipiravir, demonstra...

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Autores principales:	Ashleigh Shannon, Barbara Selisko, Nhung-Thi-Tuyet Le, Johanna Huchting, Franck Touret, Géraldine Piorkowski, Véronique Fattorini, François Ferron, Etienne Decroly, Chris Meier, Bruno Coutard, Olve Peersen, Bruno Canard
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6f077279cc5545ac8b6524fe1944a7d7
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spelling	oai:doaj.org-article:6f077279cc5545ac8b6524fe1944a7d72021-12-02T17:23:48ZRapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis10.1038/s41467-020-18463-z2041-1723https://doaj.org/article/6f077279cc5545ac8b6524fe1944a7d72020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18463-zhttps://doaj.org/toc/2041-1723Favipiravir (T-705) is an inhibitor of viral RNA-dependent-RNA-polymerases (RdRp) and clinical trials for the treatment of COVID-19 are ongoing. Here, the authors show that SARS-CoV nsp12 is the fastest known viral RdRp and they provide insights into the mechanism of action of Favipiravir, demonstrating that its antiviral effect on SARS-CoV-2 is primarily mediated through lethal mutagenesis.Ashleigh ShannonBarbara SeliskoNhung-Thi-Tuyet LeJohanna HuchtingFranck TouretGéraldine PiorkowskiVéronique FattoriniFrançois FerronEtienne DecrolyChris MeierBruno CoutardOlve PeersenBruno CanardNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ashleigh Shannon Barbara Selisko Nhung-Thi-Tuyet Le Johanna Huchting Franck Touret Géraldine Piorkowski Véronique Fattorini François Ferron Etienne Decroly Chris Meier Bruno Coutard Olve Peersen Bruno Canard Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis
description	Favipiravir (T-705) is an inhibitor of viral RNA-dependent-RNA-polymerases (RdRp) and clinical trials for the treatment of COVID-19 are ongoing. Here, the authors show that SARS-CoV nsp12 is the fastest known viral RdRp and they provide insights into the mechanism of action of Favipiravir, demonstrating that its antiviral effect on SARS-CoV-2 is primarily mediated through lethal mutagenesis.
format	article
author	Ashleigh Shannon Barbara Selisko Nhung-Thi-Tuyet Le Johanna Huchting Franck Touret Géraldine Piorkowski Véronique Fattorini François Ferron Etienne Decroly Chris Meier Bruno Coutard Olve Peersen Bruno Canard
author_facet	Ashleigh Shannon Barbara Selisko Nhung-Thi-Tuyet Le Johanna Huchting Franck Touret Géraldine Piorkowski Véronique Fattorini François Ferron Etienne Decroly Chris Meier Bruno Coutard Olve Peersen Bruno Canard
author_sort	Ashleigh Shannon
title	Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis
title_short	Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis
title_full	Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis
title_fullStr	Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis
title_full_unstemmed	Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis
title_sort	rapid incorporation of favipiravir by the fast and permissive viral rna polymerase complex results in sars-cov-2 lethal mutagenesis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6f077279cc5545ac8b6524fe1944a7d7
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Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis

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