Fear learning increases the number of polyribosomes associated with excitatory and inhibitory synapses in the barrel cortex.

Associative fear learning, resulting from whisker stimulation paired with application of a mild electric shock to the tail in a classical conditioning paradigm, changes the motor behavior of mice and modifies the cortical functional representation of sensory receptors involved in the conditioning. I...

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Autores principales:	Malgorzata Jasinska, Ewa Siucinska, Ewa Jasek, Jan A Litwin, Elzbieta Pyza, Malgorzata Kossut
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6f08577df58b4db3b2e5a990c64e1377
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spelling	oai:doaj.org-article:6f08577df58b4db3b2e5a990c64e13772021-11-18T07:57:33ZFear learning increases the number of polyribosomes associated with excitatory and inhibitory synapses in the barrel cortex.1932-620310.1371/journal.pone.0054301https://doaj.org/article/6f08577df58b4db3b2e5a990c64e13772013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23457448/?tool=EBIhttps://doaj.org/toc/1932-6203Associative fear learning, resulting from whisker stimulation paired with application of a mild electric shock to the tail in a classical conditioning paradigm, changes the motor behavior of mice and modifies the cortical functional representation of sensory receptors involved in the conditioning. It also induces the formation of new inhibitory synapses on double-synapse spines of the cognate barrel hollows. We studied density and distribution of polyribosomes, the putative structural markers of enhanced synaptic activation, following conditioning. By analyzing serial sections of the barrel cortex by electron microscopy and stereology, we found that the density of polyribosomes was significantly increased in dendrites of the barrel activated during conditioning. The results revealed fear learning-induced increase in the density of polyribosomes associated with both excitatory and inhibitory synapses located on dendritic spines (in both single- and double-synapse spines) and only with the inhibitory synapses located on dendritic shafts. This effect was accompanied by a significant increase in the postsynaptic density area of the excitatory synapses on single-synapse spines and of the inhibitory synapses on double-synapse spines containing polyribosomes. The present results show that associative fear learning not only induces inhibitory synaptogenesis, as demonstrated in the previous studies, but also stimulates local protein synthesis and produces modifications of the synapses that indicate their potentiation.Malgorzata JasinskaEwa SiucinskaEwa JasekJan A LitwinElzbieta PyzaMalgorzata KossutPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 2, p e54301 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Malgorzata Jasinska Ewa Siucinska Ewa Jasek Jan A Litwin Elzbieta Pyza Malgorzata Kossut Fear learning increases the number of polyribosomes associated with excitatory and inhibitory synapses in the barrel cortex.
description	Associative fear learning, resulting from whisker stimulation paired with application of a mild electric shock to the tail in a classical conditioning paradigm, changes the motor behavior of mice and modifies the cortical functional representation of sensory receptors involved in the conditioning. It also induces the formation of new inhibitory synapses on double-synapse spines of the cognate barrel hollows. We studied density and distribution of polyribosomes, the putative structural markers of enhanced synaptic activation, following conditioning. By analyzing serial sections of the barrel cortex by electron microscopy and stereology, we found that the density of polyribosomes was significantly increased in dendrites of the barrel activated during conditioning. The results revealed fear learning-induced increase in the density of polyribosomes associated with both excitatory and inhibitory synapses located on dendritic spines (in both single- and double-synapse spines) and only with the inhibitory synapses located on dendritic shafts. This effect was accompanied by a significant increase in the postsynaptic density area of the excitatory synapses on single-synapse spines and of the inhibitory synapses on double-synapse spines containing polyribosomes. The present results show that associative fear learning not only induces inhibitory synaptogenesis, as demonstrated in the previous studies, but also stimulates local protein synthesis and produces modifications of the synapses that indicate their potentiation.
format	article
author	Malgorzata Jasinska Ewa Siucinska Ewa Jasek Jan A Litwin Elzbieta Pyza Malgorzata Kossut
author_facet	Malgorzata Jasinska Ewa Siucinska Ewa Jasek Jan A Litwin Elzbieta Pyza Malgorzata Kossut
author_sort	Malgorzata Jasinska
title	Fear learning increases the number of polyribosomes associated with excitatory and inhibitory synapses in the barrel cortex.
title_short	Fear learning increases the number of polyribosomes associated with excitatory and inhibitory synapses in the barrel cortex.
title_full	Fear learning increases the number of polyribosomes associated with excitatory and inhibitory synapses in the barrel cortex.
title_fullStr	Fear learning increases the number of polyribosomes associated with excitatory and inhibitory synapses in the barrel cortex.
title_full_unstemmed	Fear learning increases the number of polyribosomes associated with excitatory and inhibitory synapses in the barrel cortex.
title_sort	fear learning increases the number of polyribosomes associated with excitatory and inhibitory synapses in the barrel cortex.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/6f08577df58b4db3b2e5a990c64e1377
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Fear learning increases the number of polyribosomes associated with excitatory and inhibitory synapses in the barrel cortex.

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