Redox/pH-Responsive Biodegradable Thiol-Hyaluronic Acid/Chitosan Charge-Reversal Nanocarriers for Triggered Drug Release

Biodegradable nanoparticles and micelles are promising nanosystems for the targeted delivery of potent anticancer drugs. By using specialized polymers as nanocarriers, targeted drug delivery and release can be developed. We developed thiol-hyaluronic acid (HA-SH)/chitosan (CS) nanoparticles with red...

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Autores principales:	Dandan Xia, Feilong Wang, Shuo Pan, Shenpo Yuan, Yunsong Liu, Yongxiang Xu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	drug-release nanocarrier dual-stimuli responsive charge reversal thiol-hyaluronic acid chitosan Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/6f0b1a0e1c63497087bd258f89fa80a8
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spelling	oai:doaj.org-article:6f0b1a0e1c63497087bd258f89fa80a82021-11-11T18:47:23ZRedox/pH-Responsive Biodegradable Thiol-Hyaluronic Acid/Chitosan Charge-Reversal Nanocarriers for Triggered Drug Release10.3390/polym132137852073-4360https://doaj.org/article/6f0b1a0e1c63497087bd258f89fa80a82021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4360/13/21/3785https://doaj.org/toc/2073-4360Biodegradable nanoparticles and micelles are promising nanosystems for the targeted delivery of potent anticancer drugs. By using specialized polymers as nanocarriers, targeted drug delivery and release can be developed. We developed thiol-hyaluronic acid (HA-SH)/chitosan (CS) nanoparticles with redox/pH dual-responsiveness via electrostatic self-assembly followed by spontaneous chemical cross-linking. The nanoparticle surface charges were reversible through different HA-SH and CS mass ratios. Doxorubicin (DOX) was used as a model drug. Dual cross-linked nanoparticles with diameters of approximately 300 nm exhibited superior stability under physiological conditions compared with nanoparticles without disulfide cross-linking. DOX was loaded more efficiently into negative nanoparticles (45.7 wt%) than positive nanoparticles (14.2 wt%). Drug release from negative nanoparticles (ζ potential of approximately −20) was higher (87.8 wt%) at pH 4.5 and in the presence of 10 mM glutathione. Positive nanoparticles (ζ potential of approximately +20) showed the same trend, but the release rate was slower than that of negative nanoparticles. DOX-loaded HA-SH/CS particles were taken up by human breast cancer cells (SKBR3), and the loaded drug was released, exhibiting potential antitumor efficacy. The HA-SH/CS nanoparticles in this study were stable under physiological conditions and are promising candidates for the targeted delivery and release of anticancer drugs.Dandan XiaFeilong WangShuo PanShenpo YuanYunsong LiuYongxiang XuMDPI AGarticledrug-release nanocarrierdual-stimuli responsivecharge reversalthiol-hyaluronic acidchitosanOrganic chemistryQD241-441ENPolymers, Vol 13, Iss 3785, p 3785 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	drug-release nanocarrier dual-stimuli responsive charge reversal thiol-hyaluronic acid chitosan Organic chemistry QD241-441
spellingShingle	drug-release nanocarrier dual-stimuli responsive charge reversal thiol-hyaluronic acid chitosan Organic chemistry QD241-441 Dandan Xia Feilong Wang Shuo Pan Shenpo Yuan Yunsong Liu Yongxiang Xu Redox/pH-Responsive Biodegradable Thiol-Hyaluronic Acid/Chitosan Charge-Reversal Nanocarriers for Triggered Drug Release
description	Biodegradable nanoparticles and micelles are promising nanosystems for the targeted delivery of potent anticancer drugs. By using specialized polymers as nanocarriers, targeted drug delivery and release can be developed. We developed thiol-hyaluronic acid (HA-SH)/chitosan (CS) nanoparticles with redox/pH dual-responsiveness via electrostatic self-assembly followed by spontaneous chemical cross-linking. The nanoparticle surface charges were reversible through different HA-SH and CS mass ratios. Doxorubicin (DOX) was used as a model drug. Dual cross-linked nanoparticles with diameters of approximately 300 nm exhibited superior stability under physiological conditions compared with nanoparticles without disulfide cross-linking. DOX was loaded more efficiently into negative nanoparticles (45.7 wt%) than positive nanoparticles (14.2 wt%). Drug release from negative nanoparticles (ζ potential of approximately −20) was higher (87.8 wt%) at pH 4.5 and in the presence of 10 mM glutathione. Positive nanoparticles (ζ potential of approximately +20) showed the same trend, but the release rate was slower than that of negative nanoparticles. DOX-loaded HA-SH/CS particles were taken up by human breast cancer cells (SKBR3), and the loaded drug was released, exhibiting potential antitumor efficacy. The HA-SH/CS nanoparticles in this study were stable under physiological conditions and are promising candidates for the targeted delivery and release of anticancer drugs.
format	article
author	Dandan Xia Feilong Wang Shuo Pan Shenpo Yuan Yunsong Liu Yongxiang Xu
author_facet	Dandan Xia Feilong Wang Shuo Pan Shenpo Yuan Yunsong Liu Yongxiang Xu
author_sort	Dandan Xia
title	Redox/pH-Responsive Biodegradable Thiol-Hyaluronic Acid/Chitosan Charge-Reversal Nanocarriers for Triggered Drug Release
title_short	Redox/pH-Responsive Biodegradable Thiol-Hyaluronic Acid/Chitosan Charge-Reversal Nanocarriers for Triggered Drug Release
title_full	Redox/pH-Responsive Biodegradable Thiol-Hyaluronic Acid/Chitosan Charge-Reversal Nanocarriers for Triggered Drug Release
title_fullStr	Redox/pH-Responsive Biodegradable Thiol-Hyaluronic Acid/Chitosan Charge-Reversal Nanocarriers for Triggered Drug Release
title_full_unstemmed	Redox/pH-Responsive Biodegradable Thiol-Hyaluronic Acid/Chitosan Charge-Reversal Nanocarriers for Triggered Drug Release
title_sort	redox/ph-responsive biodegradable thiol-hyaluronic acid/chitosan charge-reversal nanocarriers for triggered drug release
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6f0b1a0e1c63497087bd258f89fa80a8
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_version_	1718431707637481472

Redox/pH-Responsive Biodegradable Thiol-Hyaluronic Acid/Chitosan Charge-Reversal Nanocarriers for Triggered Drug Release

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