Association of plasma Aß peptides with blood pressure in the elderly.
<h4>Background</h4>Aß peptides are often considered as catabolic by-products of the amyloid ß protein precursor (APP), with unknown physiological functions. However, several biological properties have been tentatively attributed to these peptides, including a role in vasomotion. We asses...
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2011
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oai:doaj.org-article:6f0cab3571dc40e7a4138ded5e45958e2021-11-18T06:55:42ZAssociation of plasma Aß peptides with blood pressure in the elderly.1932-620310.1371/journal.pone.0018536https://doaj.org/article/6f0cab3571dc40e7a4138ded5e45958e2011-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21525986/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Aß peptides are often considered as catabolic by-products of the amyloid ß protein precursor (APP), with unknown physiological functions. However, several biological properties have been tentatively attributed to these peptides, including a role in vasomotion. We assess whether plasma Aß peptide levels might be associated with systolic and diastolic blood pressure values (SBP and DBP, respectively).<h4>Methodology/principal findings</h4>Plasma Aß(1-40) and Aß(1-42) levels were measured using an xMAP-based assay in 1,972 individuals (none of whom were taking antihypertensive drugs) from 3 independent studies: the French population-based 3C and MONA-LISA (Lille) studies (n = 627 and n = 769, respectively) and the Australian, longitudinal AIBL study (n = 576). In the combined sample, the Aß(1-42)/ Aß(1-40) ratio was significantly and inversely associated with SBP (p = 0.03) and a similar trend was observed for DBP (p = 0.06). Using the median age (69) as a cut-off, the Aß(1-42)/Aß(1-40) ratio was strongly associated with both SBP and DBP in elderly individuals (p = 0.002 and p = 0.03, respectively). Consistently, a high Aß(1-42)/ Aß(1-40) ratio was associated with a lower risk of hypertension in both the combined whole sample (odds ratio [OR], 0.71; 95% confidence interval [CI], 0.56-0.90) and (to an even greater extent) in the elderly subjects (OR, 0.53; 95% CI, 0.37-0.75). Lastly, all these associations appeared to be primarily driven by the level of plasma Aß(1-40).<h4>Conclusion</h4>The plasma Aß(1-42)/Aß(1-40) ratio is inversely associated with SBP, DBP and the risk of hypertension in elderly subjects, suggesting that Aß peptides affect blood pressure in vivo. These results may be particularly relevant in Alzheimer's disease, in which a high Aß(1-42)/Aß(1-40) plasma ratio is reportedly associated with a decreased risk of incident disease.Jean-Charles LambertJean DallongevilleKathryn A EllisSusanna Schraen-MaschkeJames LuiSimon LawsJulie DumontFlorence RichardDominique CottelClaudine BerrDavid AmesColin L MastersChristopher C RoweCassandra SzoekeChristophe TzourioJean-François DartiguesLuc BuéeRalph MartinsPhilippe AmouyelPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 4, p e18536 (2011) |
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Medicine R Science Q |
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Medicine R Science Q Jean-Charles Lambert Jean Dallongeville Kathryn A Ellis Susanna Schraen-Maschke James Lui Simon Laws Julie Dumont Florence Richard Dominique Cottel Claudine Berr David Ames Colin L Masters Christopher C Rowe Cassandra Szoeke Christophe Tzourio Jean-François Dartigues Luc Buée Ralph Martins Philippe Amouyel Association of plasma Aß peptides with blood pressure in the elderly. |
| description |
<h4>Background</h4>Aß peptides are often considered as catabolic by-products of the amyloid ß protein precursor (APP), with unknown physiological functions. However, several biological properties have been tentatively attributed to these peptides, including a role in vasomotion. We assess whether plasma Aß peptide levels might be associated with systolic and diastolic blood pressure values (SBP and DBP, respectively).<h4>Methodology/principal findings</h4>Plasma Aß(1-40) and Aß(1-42) levels were measured using an xMAP-based assay in 1,972 individuals (none of whom were taking antihypertensive drugs) from 3 independent studies: the French population-based 3C and MONA-LISA (Lille) studies (n = 627 and n = 769, respectively) and the Australian, longitudinal AIBL study (n = 576). In the combined sample, the Aß(1-42)/ Aß(1-40) ratio was significantly and inversely associated with SBP (p = 0.03) and a similar trend was observed for DBP (p = 0.06). Using the median age (69) as a cut-off, the Aß(1-42)/Aß(1-40) ratio was strongly associated with both SBP and DBP in elderly individuals (p = 0.002 and p = 0.03, respectively). Consistently, a high Aß(1-42)/ Aß(1-40) ratio was associated with a lower risk of hypertension in both the combined whole sample (odds ratio [OR], 0.71; 95% confidence interval [CI], 0.56-0.90) and (to an even greater extent) in the elderly subjects (OR, 0.53; 95% CI, 0.37-0.75). Lastly, all these associations appeared to be primarily driven by the level of plasma Aß(1-40).<h4>Conclusion</h4>The plasma Aß(1-42)/Aß(1-40) ratio is inversely associated with SBP, DBP and the risk of hypertension in elderly subjects, suggesting that Aß peptides affect blood pressure in vivo. These results may be particularly relevant in Alzheimer's disease, in which a high Aß(1-42)/Aß(1-40) plasma ratio is reportedly associated with a decreased risk of incident disease. |
| format |
article |
| author |
Jean-Charles Lambert Jean Dallongeville Kathryn A Ellis Susanna Schraen-Maschke James Lui Simon Laws Julie Dumont Florence Richard Dominique Cottel Claudine Berr David Ames Colin L Masters Christopher C Rowe Cassandra Szoeke Christophe Tzourio Jean-François Dartigues Luc Buée Ralph Martins Philippe Amouyel |
| author_facet |
Jean-Charles Lambert Jean Dallongeville Kathryn A Ellis Susanna Schraen-Maschke James Lui Simon Laws Julie Dumont Florence Richard Dominique Cottel Claudine Berr David Ames Colin L Masters Christopher C Rowe Cassandra Szoeke Christophe Tzourio Jean-François Dartigues Luc Buée Ralph Martins Philippe Amouyel |
| author_sort |
Jean-Charles Lambert |
| title |
Association of plasma Aß peptides with blood pressure in the elderly. |
| title_short |
Association of plasma Aß peptides with blood pressure in the elderly. |
| title_full |
Association of plasma Aß peptides with blood pressure in the elderly. |
| title_fullStr |
Association of plasma Aß peptides with blood pressure in the elderly. |
| title_full_unstemmed |
Association of plasma Aß peptides with blood pressure in the elderly. |
| title_sort |
association of plasma aß peptides with blood pressure in the elderly. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2011 |
| url |
https://doaj.org/article/6f0cab3571dc40e7a4138ded5e45958e |
| work_keys_str_mv |
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