Cross-ancestry GWAS meta-analysis identifies six breast cancer loci in African and European ancestry women

GWAS have enhanced our understanding for the genetic basis of breast cancer, but the majority of them were performed for European ancestry populations. Here, the authors use a cross-ancestry approach and report seven new variants associated with breast cancer risk among women of African ancestry.

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Autores principales:	Babatunde Adedokun, Zhaohui Du, Guimin Gao, Thomas U. Ahearn, Kathryn L. Lunetta, Gary Zirpoli, Jonine Figueroa, Esther M. John, Leslie Bernstein, Wei Zheng, Jennifer J. Hu, Regina G. Ziegler, Sarah Nyante, Elisa V. Bandera, Sue A. Ingles, Michael F. Press, Sandra L. Deming-Halverson, Jorge L. Rodriguez-Gil, Song Yao, Temidayo O. Ogundiran, Oladosu Ojengbede, William Blot, Melissa A. Troester, Katherine L. Nathanson, Anselm Hennis, Barbara Nemesure, Stefan Ambs, Peter N. Fiorica, Lara E. Sucheston-Campbell, Jeannette T. Bensen, Lawrence H. Kushi, Gabriela Torres-Mejia, Donglei Hu, Laura Fejerman, Manjeet K. Bolla, Joe Dennis, Alison M. Dunning, Douglas F. Easton, Kyriaki Michailidou, Paul D. P. Pharoah, Qin Wang, Dale P. Sandler, Jack A. Taylor, Katie M. O’Brien, Cari M. Kitahara, Adeyinka G. Falusi, Chinedum Babalola, Joel Yarney, Baffour Awuah, Beatrice Addai-Wiafe, The GBHS Study Team, Stephen J. Chanock, Andrew F. Olshan, Christine B. Ambrosone, David V. Conti, Elad Ziv, Olufunmilayo I. Olopade, Montserrat Garcia-Closas, Julie R. Palmer, Christopher A. Haiman, Dezheng Huo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6f0e5304a68d47149e5deb98e9b77d0a
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spelling	oai:doaj.org-article:6f0e5304a68d47149e5deb98e9b77d0a2021-12-02T16:14:49ZCross-ancestry GWAS meta-analysis identifies six breast cancer loci in African and European ancestry women10.1038/s41467-021-24327-x2041-1723https://doaj.org/article/6f0e5304a68d47149e5deb98e9b77d0a2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24327-xhttps://doaj.org/toc/2041-1723GWAS have enhanced our understanding for the genetic basis of breast cancer, but the majority of them were performed for European ancestry populations. Here, the authors use a cross-ancestry approach and report seven new variants associated with breast cancer risk among women of African ancestry.Babatunde AdedokunZhaohui DuGuimin GaoThomas U. AhearnKathryn L. LunettaGary ZirpoliJonine FigueroaEsther M. JohnLeslie BernsteinWei ZhengJennifer J. HuRegina G. ZieglerSarah NyanteElisa V. BanderaSue A. InglesMichael F. PressSandra L. Deming-HalversonJorge L. Rodriguez-GilSong YaoTemidayo O. OgundiranOladosu OjengbedeWilliam BlotMelissa A. TroesterKatherine L. NathansonAnselm HennisBarbara NemesureStefan AmbsPeter N. FioricaLara E. Sucheston-CampbellJeannette T. BensenLawrence H. KushiGabriela Torres-MejiaDonglei HuLaura FejermanManjeet K. BollaJoe DennisAlison M. DunningDouglas F. EastonKyriaki MichailidouPaul D. P. PharoahQin WangDale P. SandlerJack A. TaylorKatie M. O’BrienCari M. KitaharaAdeyinka G. FalusiChinedum BabalolaJoel YarneyBaffour AwuahBeatrice Addai-WiafeThe GBHS Study TeamStephen J. ChanockAndrew F. OlshanChristine B. AmbrosoneDavid V. ContiElad ZivOlufunmilayo I. OlopadeMontserrat Garcia-ClosasJulie R. PalmerChristopher A. HaimanDezheng HuoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Babatunde Adedokun Zhaohui Du Guimin Gao Thomas U. Ahearn Kathryn L. Lunetta Gary Zirpoli Jonine Figueroa Esther M. John Leslie Bernstein Wei Zheng Jennifer J. Hu Regina G. Ziegler Sarah Nyante Elisa V. Bandera Sue A. Ingles Michael F. Press Sandra L. Deming-Halverson Jorge L. Rodriguez-Gil Song Yao Temidayo O. Ogundiran Oladosu Ojengbede William Blot Melissa A. Troester Katherine L. Nathanson Anselm Hennis Barbara Nemesure Stefan Ambs Peter N. Fiorica Lara E. Sucheston-Campbell Jeannette T. Bensen Lawrence H. Kushi Gabriela Torres-Mejia Donglei Hu Laura Fejerman Manjeet K. Bolla Joe Dennis Alison M. Dunning Douglas F. Easton Kyriaki Michailidou Paul D. P. Pharoah Qin Wang Dale P. Sandler Jack A. Taylor Katie M. O’Brien Cari M. Kitahara Adeyinka G. Falusi Chinedum Babalola Joel Yarney Baffour Awuah Beatrice Addai-Wiafe The GBHS Study Team Stephen J. Chanock Andrew F. Olshan Christine B. Ambrosone David V. Conti Elad Ziv Olufunmilayo I. Olopade Montserrat Garcia-Closas Julie R. Palmer Christopher A. Haiman Dezheng Huo Cross-ancestry GWAS meta-analysis identifies six breast cancer loci in African and European ancestry women
description	GWAS have enhanced our understanding for the genetic basis of breast cancer, but the majority of them were performed for European ancestry populations. Here, the authors use a cross-ancestry approach and report seven new variants associated with breast cancer risk among women of African ancestry.
format	article
author	Babatunde Adedokun Zhaohui Du Guimin Gao Thomas U. Ahearn Kathryn L. Lunetta Gary Zirpoli Jonine Figueroa Esther M. John Leslie Bernstein Wei Zheng Jennifer J. Hu Regina G. Ziegler Sarah Nyante Elisa V. Bandera Sue A. Ingles Michael F. Press Sandra L. Deming-Halverson Jorge L. Rodriguez-Gil Song Yao Temidayo O. Ogundiran Oladosu Ojengbede William Blot Melissa A. Troester Katherine L. Nathanson Anselm Hennis Barbara Nemesure Stefan Ambs Peter N. Fiorica Lara E. Sucheston-Campbell Jeannette T. Bensen Lawrence H. Kushi Gabriela Torres-Mejia Donglei Hu Laura Fejerman Manjeet K. Bolla Joe Dennis Alison M. Dunning Douglas F. Easton Kyriaki Michailidou Paul D. P. Pharoah Qin Wang Dale P. Sandler Jack A. Taylor Katie M. O’Brien Cari M. Kitahara Adeyinka G. Falusi Chinedum Babalola Joel Yarney Baffour Awuah Beatrice Addai-Wiafe The GBHS Study Team Stephen J. Chanock Andrew F. Olshan Christine B. Ambrosone David V. Conti Elad Ziv Olufunmilayo I. Olopade Montserrat Garcia-Closas Julie R. Palmer Christopher A. Haiman Dezheng Huo
author_facet	Babatunde Adedokun Zhaohui Du Guimin Gao Thomas U. Ahearn Kathryn L. Lunetta Gary Zirpoli Jonine Figueroa Esther M. John Leslie Bernstein Wei Zheng Jennifer J. Hu Regina G. Ziegler Sarah Nyante Elisa V. Bandera Sue A. Ingles Michael F. Press Sandra L. Deming-Halverson Jorge L. Rodriguez-Gil Song Yao Temidayo O. Ogundiran Oladosu Ojengbede William Blot Melissa A. Troester Katherine L. Nathanson Anselm Hennis Barbara Nemesure Stefan Ambs Peter N. Fiorica Lara E. Sucheston-Campbell Jeannette T. Bensen Lawrence H. Kushi Gabriela Torres-Mejia Donglei Hu Laura Fejerman Manjeet K. Bolla Joe Dennis Alison M. Dunning Douglas F. Easton Kyriaki Michailidou Paul D. P. Pharoah Qin Wang Dale P. Sandler Jack A. Taylor Katie M. O’Brien Cari M. Kitahara Adeyinka G. Falusi Chinedum Babalola Joel Yarney Baffour Awuah Beatrice Addai-Wiafe The GBHS Study Team Stephen J. Chanock Andrew F. Olshan Christine B. Ambrosone David V. Conti Elad Ziv Olufunmilayo I. Olopade Montserrat Garcia-Closas Julie R. Palmer Christopher A. Haiman Dezheng Huo
author_sort	Babatunde Adedokun
title	Cross-ancestry GWAS meta-analysis identifies six breast cancer loci in African and European ancestry women
title_short	Cross-ancestry GWAS meta-analysis identifies six breast cancer loci in African and European ancestry women
title_full	Cross-ancestry GWAS meta-analysis identifies six breast cancer loci in African and European ancestry women
title_fullStr	Cross-ancestry GWAS meta-analysis identifies six breast cancer loci in African and European ancestry women
title_full_unstemmed	Cross-ancestry GWAS meta-analysis identifies six breast cancer loci in African and European ancestry women
title_sort	cross-ancestry gwas meta-analysis identifies six breast cancer loci in african and european ancestry women
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6f0e5304a68d47149e5deb98e9b77d0a
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Cross-ancestry GWAS meta-analysis identifies six breast cancer loci in African and European ancestry women

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