PPP1R14B Is a Prognostic and Immunological Biomarker in Pan-Cancer

Recent studies have shown that PPP1R14B was highly expressed in tumor tissues and patients with high expression of PPP1R14B had poor survival rates. However, the function and mechanisms of PPP1R14B in tumor progression remain ill defined. There was also lack of pan-cancer evidence for the relationsh...

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Autores principales:	Mingxia Deng, Long Peng, Jiamin Li, Xiong Liu, Xichun Xia, Guangqiang Li
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	PPP1R14B pan-cancer prognosis tumor infiltration MDSC Genetics QH426-470
Acceso en línea:	https://doaj.org/article/6f0e57153bd148759e912347e8ef8995
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spelling	oai:doaj.org-article:6f0e57153bd148759e912347e8ef89952021-11-11T05:47:02ZPPP1R14B Is a Prognostic and Immunological Biomarker in Pan-Cancer1664-802110.3389/fgene.2021.763561https://doaj.org/article/6f0e57153bd148759e912347e8ef89952021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fgene.2021.763561/fullhttps://doaj.org/toc/1664-8021Recent studies have shown that PPP1R14B was highly expressed in tumor tissues and patients with high expression of PPP1R14B had poor survival rates. However, the function and mechanisms of PPP1R14B in tumor progression remain ill defined. There was also lack of pan-cancer evidence for the relationship between PPP1R14B and various tumor types based on abundant clinical data. We used the TCGA project and GEO databases to perform pan-cancer analysis of PPP1R14B, including expression differences, correlations between expression levels and survival, genetic alteration, immune infiltration, and relevant cellular pathways, to investigate the functions and potential mechanisms of PPP1R14B in the pathogenesis or clinical prognosis of different cancers. Herein, we found that PPP1R14B was involved in the prognosis of pan-cancer and closely related to immune infiltration. Increased PPP1R14B expression correlated with poor prognosis and increased immune infiltration levels in myeloid-derived suppressor cells (MDSCs). Our studies suggest that PPP1R14B can be used as a prognostic biomarker for pan-cancer. Our findings may provide an antitumor strategy targeting PPP1R14B, including manipulation of tumor cell growth or the tumor microenvironment, especially myeloid-derived suppressor cell infiltration.Mingxia DengLong PengJiamin LiXiong LiuXichun XiaGuangqiang LiFrontiers Media S.A.articlePPP1R14Bpan-cancerprognosistumor infiltrationMDSCGeneticsQH426-470ENFrontiers in Genetics, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	PPP1R14B pan-cancer prognosis tumor infiltration MDSC Genetics QH426-470
spellingShingle	PPP1R14B pan-cancer prognosis tumor infiltration MDSC Genetics QH426-470 Mingxia Deng Long Peng Jiamin Li Xiong Liu Xichun Xia Guangqiang Li PPP1R14B Is a Prognostic and Immunological Biomarker in Pan-Cancer
description	Recent studies have shown that PPP1R14B was highly expressed in tumor tissues and patients with high expression of PPP1R14B had poor survival rates. However, the function and mechanisms of PPP1R14B in tumor progression remain ill defined. There was also lack of pan-cancer evidence for the relationship between PPP1R14B and various tumor types based on abundant clinical data. We used the TCGA project and GEO databases to perform pan-cancer analysis of PPP1R14B, including expression differences, correlations between expression levels and survival, genetic alteration, immune infiltration, and relevant cellular pathways, to investigate the functions and potential mechanisms of PPP1R14B in the pathogenesis or clinical prognosis of different cancers. Herein, we found that PPP1R14B was involved in the prognosis of pan-cancer and closely related to immune infiltration. Increased PPP1R14B expression correlated with poor prognosis and increased immune infiltration levels in myeloid-derived suppressor cells (MDSCs). Our studies suggest that PPP1R14B can be used as a prognostic biomarker for pan-cancer. Our findings may provide an antitumor strategy targeting PPP1R14B, including manipulation of tumor cell growth or the tumor microenvironment, especially myeloid-derived suppressor cell infiltration.
format	article
author	Mingxia Deng Long Peng Jiamin Li Xiong Liu Xichun Xia Guangqiang Li
author_facet	Mingxia Deng Long Peng Jiamin Li Xiong Liu Xichun Xia Guangqiang Li
author_sort	Mingxia Deng
title	PPP1R14B Is a Prognostic and Immunological Biomarker in Pan-Cancer
title_short	PPP1R14B Is a Prognostic and Immunological Biomarker in Pan-Cancer
title_full	PPP1R14B Is a Prognostic and Immunological Biomarker in Pan-Cancer
title_fullStr	PPP1R14B Is a Prognostic and Immunological Biomarker in Pan-Cancer
title_full_unstemmed	PPP1R14B Is a Prognostic and Immunological Biomarker in Pan-Cancer
title_sort	ppp1r14b is a prognostic and immunological biomarker in pan-cancer
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/6f0e57153bd148759e912347e8ef8995
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PPP1R14B Is a Prognostic and Immunological Biomarker in Pan-Cancer

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