Integrated genomics and comprehensive validation reveal drivers of genomic evolution in esophageal adenocarcinoma

Subodh Kumar et al. identify a gene signature correlated with genomic instability and poor survival in esophageal adenocarcinoma (EAC), using a combination of integrative genomic analysis of patient data and laboratory validation in cell line models and mice. They find that inhibitors of some of the...

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Autores principales:	Subodh Kumar, Leutz Buon, Srikanth Talluri, Marco Roncador, Chengcheng Liao, Jiangning Zhao, Jialan Shi, Chandraditya Chakraborty, Gabriel Gonzalez, Yu-Tzu Tai, Rao Prabhala, Mehmet K. Samur, Nikhil C. Munshi, Masood A. Shammas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6f113318075d4e0bb3590bebd59eb8e1
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spelling	oai:doaj.org-article:6f113318075d4e0bb3590bebd59eb8e12021-12-02T14:49:10ZIntegrated genomics and comprehensive validation reveal drivers of genomic evolution in esophageal adenocarcinoma10.1038/s42003-021-02125-x2399-3642https://doaj.org/article/6f113318075d4e0bb3590bebd59eb8e12021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02125-xhttps://doaj.org/toc/2399-3642Subodh Kumar et al. identify a gene signature correlated with genomic instability and poor survival in esophageal adenocarcinoma (EAC), using a combination of integrative genomic analysis of patient data and laboratory validation in cell line models and mice. They find that inhibitors of some of the identified proteins, including TTK, could be used to reduce genomic evolution as well as inhibit growth of EAC cells.Subodh KumarLeutz BuonSrikanth TalluriMarco RoncadorChengcheng LiaoJiangning ZhaoJialan ShiChandraditya ChakrabortyGabriel GonzalezYu-Tzu TaiRao PrabhalaMehmet K. SamurNikhil C. MunshiMasood A. ShammasNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Subodh Kumar Leutz Buon Srikanth Talluri Marco Roncador Chengcheng Liao Jiangning Zhao Jialan Shi Chandraditya Chakraborty Gabriel Gonzalez Yu-Tzu Tai Rao Prabhala Mehmet K. Samur Nikhil C. Munshi Masood A. Shammas Integrated genomics and comprehensive validation reveal drivers of genomic evolution in esophageal adenocarcinoma
description	Subodh Kumar et al. identify a gene signature correlated with genomic instability and poor survival in esophageal adenocarcinoma (EAC), using a combination of integrative genomic analysis of patient data and laboratory validation in cell line models and mice. They find that inhibitors of some of the identified proteins, including TTK, could be used to reduce genomic evolution as well as inhibit growth of EAC cells.
format	article
author	Subodh Kumar Leutz Buon Srikanth Talluri Marco Roncador Chengcheng Liao Jiangning Zhao Jialan Shi Chandraditya Chakraborty Gabriel Gonzalez Yu-Tzu Tai Rao Prabhala Mehmet K. Samur Nikhil C. Munshi Masood A. Shammas
author_facet	Subodh Kumar Leutz Buon Srikanth Talluri Marco Roncador Chengcheng Liao Jiangning Zhao Jialan Shi Chandraditya Chakraborty Gabriel Gonzalez Yu-Tzu Tai Rao Prabhala Mehmet K. Samur Nikhil C. Munshi Masood A. Shammas
author_sort	Subodh Kumar
title	Integrated genomics and comprehensive validation reveal drivers of genomic evolution in esophageal adenocarcinoma
title_short	Integrated genomics and comprehensive validation reveal drivers of genomic evolution in esophageal adenocarcinoma
title_full	Integrated genomics and comprehensive validation reveal drivers of genomic evolution in esophageal adenocarcinoma
title_fullStr	Integrated genomics and comprehensive validation reveal drivers of genomic evolution in esophageal adenocarcinoma
title_full_unstemmed	Integrated genomics and comprehensive validation reveal drivers of genomic evolution in esophageal adenocarcinoma
title_sort	integrated genomics and comprehensive validation reveal drivers of genomic evolution in esophageal adenocarcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6f113318075d4e0bb3590bebd59eb8e1
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Integrated genomics and comprehensive validation reveal drivers of genomic evolution in esophageal adenocarcinoma

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