Biomarkers of subclinical atherosclerosis in patients with psoriasis

Abstract Psoriasis is linked with increased risk of cardiovascular disease (CVD) that is underestimated by traditional risk stratification. We conducted a large-scale plasma proteomic analysis by use of a proximity extension assay in 85 patients with a history of moderate-to-severe psoriasis with or...

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Autores principales:	Hannah Kaiser, Xing Wang, Amanda Kvist-Hansen, Martin Krakauer, Peter Michael Gørtz, Benjamin D. McCauley, Lone Skov, Christine Becker, Peter Riis Hansen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6f131e9fedf64742b1a91acddcc8ef0d
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spelling	oai:doaj.org-article:6f131e9fedf64742b1a91acddcc8ef0d2021-11-08T10:54:28ZBiomarkers of subclinical atherosclerosis in patients with psoriasis10.1038/s41598-021-00999-92045-2322https://doaj.org/article/6f131e9fedf64742b1a91acddcc8ef0d2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-00999-9https://doaj.org/toc/2045-2322Abstract Psoriasis is linked with increased risk of cardiovascular disease (CVD) that is underestimated by traditional risk stratification. We conducted a large-scale plasma proteomic analysis by use of a proximity extension assay in 85 patients with a history of moderate-to-severe psoriasis with or without established atherosclerotic CVD. Differentially expressed proteins associated with CVD were correlated with subclinical atherosclerotic markers including vascular inflammation determined by 18F-fluorodeoxyglucose positron emission tomography/computed tomography, carotid intima-media thickness (CIMT), carotid artery plaques, and coronary artery calcium score (CCS) in the patients without CVD and statin treatment. We also examined the association between the neutrophil-to-lymphocyte ratio (NLR) and subclinical atherosclerosis. In unadjusted analyses, growth differentiation factor-15 (GDF-15) levels and NLR were increased, while tumor necrosis factor (TNF)-related activation-inducing ligand (TRANCE) and TNF-related apoptosis-induced ligand (TRAIL) levels were decreased in patients with established CVD compared to those without CVD. Among patients with psoriasis without CVD and statin treatment, GDF-15 levels were negatively associated with vascular inflammation in the ascending aorta and entire aorta, and positively associated with CIMT and CCS. NLR was positively associated with vascular inflammation in the carotid arteries. Our data suggest that circulating GDF-15 levels and NLR might serve as biomarkers of subclinical atherosclerosis in patients with psoriasis.Hannah KaiserXing WangAmanda Kvist-HansenMartin KrakauerPeter Michael GørtzBenjamin D. McCauleyLone SkovChristine BeckerPeter Riis HansenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hannah Kaiser Xing Wang Amanda Kvist-Hansen Martin Krakauer Peter Michael Gørtz Benjamin D. McCauley Lone Skov Christine Becker Peter Riis Hansen Biomarkers of subclinical atherosclerosis in patients with psoriasis
description	Abstract Psoriasis is linked with increased risk of cardiovascular disease (CVD) that is underestimated by traditional risk stratification. We conducted a large-scale plasma proteomic analysis by use of a proximity extension assay in 85 patients with a history of moderate-to-severe psoriasis with or without established atherosclerotic CVD. Differentially expressed proteins associated with CVD were correlated with subclinical atherosclerotic markers including vascular inflammation determined by 18F-fluorodeoxyglucose positron emission tomography/computed tomography, carotid intima-media thickness (CIMT), carotid artery plaques, and coronary artery calcium score (CCS) in the patients without CVD and statin treatment. We also examined the association between the neutrophil-to-lymphocyte ratio (NLR) and subclinical atherosclerosis. In unadjusted analyses, growth differentiation factor-15 (GDF-15) levels and NLR were increased, while tumor necrosis factor (TNF)-related activation-inducing ligand (TRANCE) and TNF-related apoptosis-induced ligand (TRAIL) levels were decreased in patients with established CVD compared to those without CVD. Among patients with psoriasis without CVD and statin treatment, GDF-15 levels were negatively associated with vascular inflammation in the ascending aorta and entire aorta, and positively associated with CIMT and CCS. NLR was positively associated with vascular inflammation in the carotid arteries. Our data suggest that circulating GDF-15 levels and NLR might serve as biomarkers of subclinical atherosclerosis in patients with psoriasis.
format	article
author	Hannah Kaiser Xing Wang Amanda Kvist-Hansen Martin Krakauer Peter Michael Gørtz Benjamin D. McCauley Lone Skov Christine Becker Peter Riis Hansen
author_facet	Hannah Kaiser Xing Wang Amanda Kvist-Hansen Martin Krakauer Peter Michael Gørtz Benjamin D. McCauley Lone Skov Christine Becker Peter Riis Hansen
author_sort	Hannah Kaiser
title	Biomarkers of subclinical atherosclerosis in patients with psoriasis
title_short	Biomarkers of subclinical atherosclerosis in patients with psoriasis
title_full	Biomarkers of subclinical atherosclerosis in patients with psoriasis
title_fullStr	Biomarkers of subclinical atherosclerosis in patients with psoriasis
title_full_unstemmed	Biomarkers of subclinical atherosclerosis in patients with psoriasis
title_sort	biomarkers of subclinical atherosclerosis in patients with psoriasis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6f131e9fedf64742b1a91acddcc8ef0d
work_keys_str_mv	AT hannahkaiser biomarkersofsubclinicalatherosclerosisinpatientswithpsoriasis AT xingwang biomarkersofsubclinicalatherosclerosisinpatientswithpsoriasis AT amandakvisthansen biomarkersofsubclinicalatherosclerosisinpatientswithpsoriasis AT martinkrakauer biomarkersofsubclinicalatherosclerosisinpatientswithpsoriasis AT petermichaelgørtz biomarkersofsubclinicalatherosclerosisinpatientswithpsoriasis AT benjamindmccauley biomarkersofsubclinicalatherosclerosisinpatientswithpsoriasis AT loneskov biomarkersofsubclinicalatherosclerosisinpatientswithpsoriasis AT christinebecker biomarkersofsubclinicalatherosclerosisinpatientswithpsoriasis AT peterriishansen biomarkersofsubclinicalatherosclerosisinpatientswithpsoriasis
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Biomarkers of subclinical atherosclerosis in patients with psoriasis

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