KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting
Specificity of inhibitors of voltage-gated ion channels is crucial for their use as therapeutics. Here, the authors show that adamantane derivatives interact with a specific binding site on fenestrations that only become available when accessory subunits are bound to the channel.
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Nature Portfolio
2016
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oai:doaj.org-article:6f13dc5b883d4828afc6c8522bd13d5d2021-12-02T17:32:50ZKCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting10.1038/ncomms127952041-1723https://doaj.org/article/6f13dc5b883d4828afc6c8522bd13d5d2016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms12795https://doaj.org/toc/2041-1723Specificity of inhibitors of voltage-gated ion channels is crucial for their use as therapeutics. Here, the authors show that adamantane derivatives interact with a specific binding site on fenestrations that only become available when accessory subunits are bound to the channel.Eva WrobelIna RothenbergChristoph KrispFranziska HundtBenjamin FraenzelKarina EckeyJoannes T. M. LindersDavid J. GallacherRob TowartLutz PottMichael PuschTao YangDan M. RodenHarley T. KurataEric Schulze-BahrNathalie Strutz-SeebohmDirk WoltersGuiscard SeebohmNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016) |
| institution |
DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Eva Wrobel Ina Rothenberg Christoph Krisp Franziska Hundt Benjamin Fraenzel Karina Eckey Joannes T. M. Linders David J. Gallacher Rob Towart Lutz Pott Michael Pusch Tao Yang Dan M. Roden Harley T. Kurata Eric Schulze-Bahr Nathalie Strutz-Seebohm Dirk Wolters Guiscard Seebohm KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting |
| description |
Specificity of inhibitors of voltage-gated ion channels is crucial for their use as therapeutics. Here, the authors show that adamantane derivatives interact with a specific binding site on fenestrations that only become available when accessory subunits are bound to the channel. |
| format |
article |
| author |
Eva Wrobel Ina Rothenberg Christoph Krisp Franziska Hundt Benjamin Fraenzel Karina Eckey Joannes T. M. Linders David J. Gallacher Rob Towart Lutz Pott Michael Pusch Tao Yang Dan M. Roden Harley T. Kurata Eric Schulze-Bahr Nathalie Strutz-Seebohm Dirk Wolters Guiscard Seebohm |
| author_facet |
Eva Wrobel Ina Rothenberg Christoph Krisp Franziska Hundt Benjamin Fraenzel Karina Eckey Joannes T. M. Linders David J. Gallacher Rob Towart Lutz Pott Michael Pusch Tao Yang Dan M. Roden Harley T. Kurata Eric Schulze-Bahr Nathalie Strutz-Seebohm Dirk Wolters Guiscard Seebohm |
| author_sort |
Eva Wrobel |
| title |
KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting |
| title_short |
KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting |
| title_full |
KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting |
| title_fullStr |
KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting |
| title_full_unstemmed |
KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting |
| title_sort |
kcne1 induces fenestration in the kv7.1/kcne1 channel complex that allows for highly specific pharmacological targeting |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/6f13dc5b883d4828afc6c8522bd13d5d |
| work_keys_str_mv |
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| _version_ |
1718380194113257472 |