Role of DNA methylation on the association between physical activity and cardiovascular diseases: results from the longitudinal multi-ethnic study of atherosclerosis (MESA) cohort

Abstract Background The complexity of physical activity (PA) and DNA methylation interaction in the development of cardiovascular disease (CVD) is rarely simultaneously investigated in one study. We examined the role of DNA methylation on the association between PA and CVD. Results The Multi-Ethnic...

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Autores principales:	Hangchuan Shi, Deborah J. Ossip, Nicole L. Mayo, Daniel A. Lopez, Robert C. Block, Wendy S. Post, Alain G. Bertoni, Jingzhong Ding, Si Chen, Chen Yan, Zidian Xie, Ina Hoeschele, Yongmei Liu, Dongmei Li
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Cardiovascular disease Physical activity DNA methylation MESA Structural equation modeling Biotechnology TP248.13-248.65 Genetics QH426-470
Acceso en línea:	https://doaj.org/article/6f13f519e27b4aaebec37802b32b3b86
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spelling	oai:doaj.org-article:6f13f519e27b4aaebec37802b32b3b862021-11-08T10:57:30ZRole of DNA methylation on the association between physical activity and cardiovascular diseases: results from the longitudinal multi-ethnic study of atherosclerosis (MESA) cohort10.1186/s12864-021-08108-w1471-2164https://doaj.org/article/6f13f519e27b4aaebec37802b32b3b862021-11-01T00:00:00Zhttps://doi.org/10.1186/s12864-021-08108-whttps://doaj.org/toc/1471-2164Abstract Background The complexity of physical activity (PA) and DNA methylation interaction in the development of cardiovascular disease (CVD) is rarely simultaneously investigated in one study. We examined the role of DNA methylation on the association between PA and CVD. Results The Multi-Ethnic Study of Atherosclerosis (MESA) cohort Exam 5 data with 1065 participants free of CVD were used for final analysis. The quartile categorical total PA variable was created by activity intensity (METs/week). During a median follow-up of 4.0 years, 69 participants developed CVD. Illumina HumanMethylation450 BeadChip was used to provide genome-wide DNA methylation profiles in purified human monocytes (CD14+). We identified 23 candidate DNA methylation loci to be associated with both PA and CVD. We used the structural equation modeling (SEM) approach to test the complex relationships among multiple variables and the roles of mediators. Three of the 23 identified loci (corresponding to genes VPS13D, PIK3CD and VPS45) remained as significant mediators in the final SEM model along with other covariates. Bridged by the three genes, the 2nd PA quartile (β = − 0.959; 95%CI: − 1.554 to − 0.449) and the 3rd PA quartile (β = − 0.944; 95%CI: − 1.628 to − 0.413) showed the greatest inverse associations with CVD development, while the 4th PA quartile had a relatively weaker inverse association (β = − 0.355; 95%CI: − 0.713 to − 0.124). Conclusions The current study is among the first to simultaneously examine the relationships among PA, DNA methylation, and CVD in a large cohort with long-term exposure. We identified three DNA methylation loci bridged the association between PA and CVD. The function of the identified genes warrants further investigation in the pathogenesis of CVD.Hangchuan ShiDeborah J. OssipNicole L. MayoDaniel A. LopezRobert C. BlockWendy S. PostAlain G. BertoniJingzhong DingSi ChenChen YanZidian XieIna HoescheleYongmei LiuDongmei LiBMCarticleCardiovascular diseasePhysical activityDNA methylationMESAStructural equation modelingBiotechnologyTP248.13-248.65GeneticsQH426-470ENBMC Genomics, Vol 22, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cardiovascular disease Physical activity DNA methylation MESA Structural equation modeling Biotechnology TP248.13-248.65 Genetics QH426-470
spellingShingle	Cardiovascular disease Physical activity DNA methylation MESA Structural equation modeling Biotechnology TP248.13-248.65 Genetics QH426-470 Hangchuan Shi Deborah J. Ossip Nicole L. Mayo Daniel A. Lopez Robert C. Block Wendy S. Post Alain G. Bertoni Jingzhong Ding Si Chen Chen Yan Zidian Xie Ina Hoeschele Yongmei Liu Dongmei Li Role of DNA methylation on the association between physical activity and cardiovascular diseases: results from the longitudinal multi-ethnic study of atherosclerosis (MESA) cohort
description	Abstract Background The complexity of physical activity (PA) and DNA methylation interaction in the development of cardiovascular disease (CVD) is rarely simultaneously investigated in one study. We examined the role of DNA methylation on the association between PA and CVD. Results The Multi-Ethnic Study of Atherosclerosis (MESA) cohort Exam 5 data with 1065 participants free of CVD were used for final analysis. The quartile categorical total PA variable was created by activity intensity (METs/week). During a median follow-up of 4.0 years, 69 participants developed CVD. Illumina HumanMethylation450 BeadChip was used to provide genome-wide DNA methylation profiles in purified human monocytes (CD14+). We identified 23 candidate DNA methylation loci to be associated with both PA and CVD. We used the structural equation modeling (SEM) approach to test the complex relationships among multiple variables and the roles of mediators. Three of the 23 identified loci (corresponding to genes VPS13D, PIK3CD and VPS45) remained as significant mediators in the final SEM model along with other covariates. Bridged by the three genes, the 2nd PA quartile (β = − 0.959; 95%CI: − 1.554 to − 0.449) and the 3rd PA quartile (β = − 0.944; 95%CI: − 1.628 to − 0.413) showed the greatest inverse associations with CVD development, while the 4th PA quartile had a relatively weaker inverse association (β = − 0.355; 95%CI: − 0.713 to − 0.124). Conclusions The current study is among the first to simultaneously examine the relationships among PA, DNA methylation, and CVD in a large cohort with long-term exposure. We identified three DNA methylation loci bridged the association between PA and CVD. The function of the identified genes warrants further investigation in the pathogenesis of CVD.
format	article
author	Hangchuan Shi Deborah J. Ossip Nicole L. Mayo Daniel A. Lopez Robert C. Block Wendy S. Post Alain G. Bertoni Jingzhong Ding Si Chen Chen Yan Zidian Xie Ina Hoeschele Yongmei Liu Dongmei Li
author_facet	Hangchuan Shi Deborah J. Ossip Nicole L. Mayo Daniel A. Lopez Robert C. Block Wendy S. Post Alain G. Bertoni Jingzhong Ding Si Chen Chen Yan Zidian Xie Ina Hoeschele Yongmei Liu Dongmei Li
author_sort	Hangchuan Shi
title	Role of DNA methylation on the association between physical activity and cardiovascular diseases: results from the longitudinal multi-ethnic study of atherosclerosis (MESA) cohort
title_short	Role of DNA methylation on the association between physical activity and cardiovascular diseases: results from the longitudinal multi-ethnic study of atherosclerosis (MESA) cohort
title_full	Role of DNA methylation on the association between physical activity and cardiovascular diseases: results from the longitudinal multi-ethnic study of atherosclerosis (MESA) cohort
title_fullStr	Role of DNA methylation on the association between physical activity and cardiovascular diseases: results from the longitudinal multi-ethnic study of atherosclerosis (MESA) cohort
title_full_unstemmed	Role of DNA methylation on the association between physical activity and cardiovascular diseases: results from the longitudinal multi-ethnic study of atherosclerosis (MESA) cohort
title_sort	role of dna methylation on the association between physical activity and cardiovascular diseases: results from the longitudinal multi-ethnic study of atherosclerosis (mesa) cohort
publisher	BMC
publishDate	2021
url	https://doaj.org/article/6f13f519e27b4aaebec37802b32b3b86
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Role of DNA methylation on the association between physical activity and cardiovascular diseases: results from the longitudinal multi-ethnic study of atherosclerosis (MESA) cohort

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