Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins

Mutations in optineurin that cause defects in the interaction with TBK1 are associated with neurodegenerative diseases. Here, the authors report the structure of this complex, and outline a general binding mode for these proteins.

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Autores principales:	Faxiang Li, Xingqiao Xie, Yingli Wang, Jianping Liu, Xiaofang Cheng, Yujiao Guo, Yukang Gong, Shichen Hu, Lifeng Pan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6f149eadfad341e89e90455b3ba5ac86
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spelling	oai:doaj.org-article:6f149eadfad341e89e90455b3ba5ac862021-12-02T17:32:38ZStructural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins10.1038/ncomms127082041-1723https://doaj.org/article/6f149eadfad341e89e90455b3ba5ac862016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12708https://doaj.org/toc/2041-1723Mutations in optineurin that cause defects in the interaction with TBK1 are associated with neurodegenerative diseases. Here, the authors report the structure of this complex, and outline a general binding mode for these proteins.Faxiang LiXingqiao XieYingli WangJianping LiuXiaofang ChengYujiao GuoYukang GongShichen HuLifeng PanNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Faxiang Li Xingqiao Xie Yingli Wang Jianping Liu Xiaofang Cheng Yujiao Guo Yukang Gong Shichen Hu Lifeng Pan Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins
description	Mutations in optineurin that cause defects in the interaction with TBK1 are associated with neurodegenerative diseases. Here, the authors report the structure of this complex, and outline a general binding mode for these proteins.
format	article
author	Faxiang Li Xingqiao Xie Yingli Wang Jianping Liu Xiaofang Cheng Yujiao Guo Yukang Gong Shichen Hu Lifeng Pan
author_facet	Faxiang Li Xingqiao Xie Yingli Wang Jianping Liu Xiaofang Cheng Yujiao Guo Yukang Gong Shichen Hu Lifeng Pan
author_sort	Faxiang Li
title	Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins
title_short	Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins
title_full	Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins
title_fullStr	Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins
title_full_unstemmed	Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins
title_sort	structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and tbk1 proteins
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/6f149eadfad341e89e90455b3ba5ac86
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Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins

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