Prenatal stress induces long-term effects in cell turnover in the hippocampus-hypothalamus-pituitary axis in adult male rats.

Subchronic gestational stress leads to permanent modifications in the hippocampus-hypothalamus-pituitary-adrenal axis of offspring probably due to the increase in circulating glucocorticoids known to affect prenatal programming. The aim of this study was to investigate whether cell turnover is affec...

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Autores principales:	Eva Baquedano, Cristina García-Cáceres, Yolanda Diz-Chaves, Natalia Lagunas, Isabel Calmarza-Font, Iñigo Azcoitia, Luis M Garcia-Segura, Jesús Argente, Julie A Chowen, Laura M Frago
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6f1aa7944055488caea6e14a5d7c6464
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spelling	oai:doaj.org-article:6f1aa7944055488caea6e14a5d7c64642021-11-18T07:34:37ZPrenatal stress induces long-term effects in cell turnover in the hippocampus-hypothalamus-pituitary axis in adult male rats.1932-620310.1371/journal.pone.0027549https://doaj.org/article/6f1aa7944055488caea6e14a5d7c64642011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22096592/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Subchronic gestational stress leads to permanent modifications in the hippocampus-hypothalamus-pituitary-adrenal axis of offspring probably due to the increase in circulating glucocorticoids known to affect prenatal programming. The aim of this study was to investigate whether cell turnover is affected in the hippocampus-hypothalamus-pituitary axis by subchronic prenatal stress and the intracellular mechanisms involved. Restraint stress was performed in pregnant rats during the last week of gestation (45 minutes; 3 times/day). Only male offspring were used for this study and were sacrificed at 6 months of age. In prenatally stressed adults a decrease in markers of cell death and proliferation was observed in the hippocampus, hypothalamus and pituitary. This was associated with an increase in insulin-like growth factor-I mRNA levels, phosphorylation of CREB and calpastatin levels and inhibition of calpain -2 and caspase -8 activation. Levels of the anti-apoptotic protein Bcl-2 were increased and levels of the pro-apoptotic factor p53 were reduced. In conclusion, prenatal restraint stress induces a long-term decrease in cell turnover in the hippocampus-hypothalamus-pituitary axis that might be at least partly mediated by an autocrine-paracrine IGF-I effect. These changes could condition the response of this axis to future physiological and pathophysiological situations.Eva BaquedanoCristina García-CáceresYolanda Diz-ChavesNatalia LagunasIsabel Calmarza-FontIñigo AzcoitiaLuis M Garcia-SeguraJesús ArgenteJulie A ChowenLaura M FragoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 11, p e27549 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eva Baquedano Cristina García-Cáceres Yolanda Diz-Chaves Natalia Lagunas Isabel Calmarza-Font Iñigo Azcoitia Luis M Garcia-Segura Jesús Argente Julie A Chowen Laura M Frago Prenatal stress induces long-term effects in cell turnover in the hippocampus-hypothalamus-pituitary axis in adult male rats.
description	Subchronic gestational stress leads to permanent modifications in the hippocampus-hypothalamus-pituitary-adrenal axis of offspring probably due to the increase in circulating glucocorticoids known to affect prenatal programming. The aim of this study was to investigate whether cell turnover is affected in the hippocampus-hypothalamus-pituitary axis by subchronic prenatal stress and the intracellular mechanisms involved. Restraint stress was performed in pregnant rats during the last week of gestation (45 minutes; 3 times/day). Only male offspring were used for this study and were sacrificed at 6 months of age. In prenatally stressed adults a decrease in markers of cell death and proliferation was observed in the hippocampus, hypothalamus and pituitary. This was associated with an increase in insulin-like growth factor-I mRNA levels, phosphorylation of CREB and calpastatin levels and inhibition of calpain -2 and caspase -8 activation. Levels of the anti-apoptotic protein Bcl-2 were increased and levels of the pro-apoptotic factor p53 were reduced. In conclusion, prenatal restraint stress induces a long-term decrease in cell turnover in the hippocampus-hypothalamus-pituitary axis that might be at least partly mediated by an autocrine-paracrine IGF-I effect. These changes could condition the response of this axis to future physiological and pathophysiological situations.
format	article
author	Eva Baquedano Cristina García-Cáceres Yolanda Diz-Chaves Natalia Lagunas Isabel Calmarza-Font Iñigo Azcoitia Luis M Garcia-Segura Jesús Argente Julie A Chowen Laura M Frago
author_facet	Eva Baquedano Cristina García-Cáceres Yolanda Diz-Chaves Natalia Lagunas Isabel Calmarza-Font Iñigo Azcoitia Luis M Garcia-Segura Jesús Argente Julie A Chowen Laura M Frago
author_sort	Eva Baquedano
title	Prenatal stress induces long-term effects in cell turnover in the hippocampus-hypothalamus-pituitary axis in adult male rats.
title_short	Prenatal stress induces long-term effects in cell turnover in the hippocampus-hypothalamus-pituitary axis in adult male rats.
title_full	Prenatal stress induces long-term effects in cell turnover in the hippocampus-hypothalamus-pituitary axis in adult male rats.
title_fullStr	Prenatal stress induces long-term effects in cell turnover in the hippocampus-hypothalamus-pituitary axis in adult male rats.
title_full_unstemmed	Prenatal stress induces long-term effects in cell turnover in the hippocampus-hypothalamus-pituitary axis in adult male rats.
title_sort	prenatal stress induces long-term effects in cell turnover in the hippocampus-hypothalamus-pituitary axis in adult male rats.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/6f1aa7944055488caea6e14a5d7c6464
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Prenatal stress induces long-term effects in cell turnover in the hippocampus-hypothalamus-pituitary axis in adult male rats.

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