Identification of a High-Frequency Intrahost SARS-CoV-2 Spike Variant with Enhanced Cytopathic and Fusogenic Effects

The mutation rate and evolution of RNA viruses correlate with viral adaptation. While most mutations do not make significant contributions to viral molecular evolution, some are naturally selected and produce variants through positive selection.

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Autores principales:	Lynda Rocheleau, Geneviève Laroche, Kathy Fu, Corina M. Stewart, Abdulhamid O. Mohamud, Marceline Côté, Patrick M. Giguère, Marc-André Langlois, Martin Pelchat
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/6f1b37cfcbb44773b661ca22b1ff59b2
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spelling	oai:doaj.org-article:6f1b37cfcbb44773b661ca22b1ff59b22021-11-03T21:15:03ZIdentification of a High-Frequency Intrahost SARS-CoV-2 Spike Variant with Enhanced Cytopathic and Fusogenic Effects2150-751110.1128/mBio.00788-21https://doaj.org/article/6f1b37cfcbb44773b661ca22b1ff59b22021-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00788-21https://doaj.org/toc/2150-7511 The mutation rate and evolution of RNA viruses correlate with viral adaptation. While most mutations do not make significant contributions to viral molecular evolution, some are naturally selected and produce variants through positive selection.Lynda RocheleauGeneviève LarocheKathy FuCorina M. StewartAbdulhamid O. MohamudMarceline CôtéPatrick M. GiguèreMarc-André LangloisMartin PelchatAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 3 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Lynda Rocheleau Geneviève Laroche Kathy Fu Corina M. Stewart Abdulhamid O. Mohamud Marceline Côté Patrick M. Giguère Marc-André Langlois Martin Pelchat Identification of a High-Frequency Intrahost SARS-CoV-2 Spike Variant with Enhanced Cytopathic and Fusogenic Effects
description	The mutation rate and evolution of RNA viruses correlate with viral adaptation. While most mutations do not make significant contributions to viral molecular evolution, some are naturally selected and produce variants through positive selection.
format	article
author	Lynda Rocheleau Geneviève Laroche Kathy Fu Corina M. Stewart Abdulhamid O. Mohamud Marceline Côté Patrick M. Giguère Marc-André Langlois Martin Pelchat
author_facet	Lynda Rocheleau Geneviève Laroche Kathy Fu Corina M. Stewart Abdulhamid O. Mohamud Marceline Côté Patrick M. Giguère Marc-André Langlois Martin Pelchat
author_sort	Lynda Rocheleau
title	Identification of a High-Frequency Intrahost SARS-CoV-2 Spike Variant with Enhanced Cytopathic and Fusogenic Effects
title_short	Identification of a High-Frequency Intrahost SARS-CoV-2 Spike Variant with Enhanced Cytopathic and Fusogenic Effects
title_full	Identification of a High-Frequency Intrahost SARS-CoV-2 Spike Variant with Enhanced Cytopathic and Fusogenic Effects
title_fullStr	Identification of a High-Frequency Intrahost SARS-CoV-2 Spike Variant with Enhanced Cytopathic and Fusogenic Effects
title_full_unstemmed	Identification of a High-Frequency Intrahost SARS-CoV-2 Spike Variant with Enhanced Cytopathic and Fusogenic Effects
title_sort	identification of a high-frequency intrahost sars-cov-2 spike variant with enhanced cytopathic and fusogenic effects
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/6f1b37cfcbb44773b661ca22b1ff59b2
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Identification of a High-Frequency Intrahost SARS-CoV-2 Spike Variant with Enhanced Cytopathic and Fusogenic Effects

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