Greater genetic risk for adult psychiatric diseases increases vulnerability to adverse outcome after preterm birth

Abstract Preterm birth is an extreme environmental stress associated with an increased risk of later cognitive dysfunction and mental health problems. However, the extent to which preterm birth is modulated by genetic variation remains largely unclear. Here, we test for an interaction effect between...

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Autores principales:	Harriet Cullen, Saskia Selzam, Konstantina Dimitrakopoulou, Robert Plomin, A. David Edwards
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6f1c454b3c8d4dee9a7239b728a4f0df
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spelling	oai:doaj.org-article:6f1c454b3c8d4dee9a7239b728a4f0df2021-12-02T15:56:49ZGreater genetic risk for adult psychiatric diseases increases vulnerability to adverse outcome after preterm birth10.1038/s41598-021-90045-52045-2322https://doaj.org/article/6f1c454b3c8d4dee9a7239b728a4f0df2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90045-5https://doaj.org/toc/2045-2322Abstract Preterm birth is an extreme environmental stress associated with an increased risk of later cognitive dysfunction and mental health problems. However, the extent to which preterm birth is modulated by genetic variation remains largely unclear. Here, we test for an interaction effect between psychiatric polygenic risk and gestational age at birth on cognition at age four. Our sample comprises 4934 unrelated individuals (2066 individuals born < 37 weeks, 918 born < = 34 weeks). Genome-wide polygenic scores (GPS’s) were calculated for each individual for five different psychiatric pathologies: Schizophrenia, Bipolar Disorder, Major Depressive Disorder, Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorder. Linear regression modelling was used to estimate the interaction effect between psychiatric GPS and gestational age at birth (GA) on cognitive outcome for the five psychiatric disorders. We found a significant interaction effect between Schizophrenia GPS and GA (β = 0.038 ± 0.013, p = 6.85 × 10–3) and Bipolar Disorder GPS and GA (β = 0.038 ± 0.014, p = 6.61 × 10–3) on cognitive outcome. Individuals with greater genetic risk for Schizophrenia or Bipolar Disorder are more vulnerable to the adverse effects of birth at early gestational age on brain development, as assessed by cognition at age four. Better understanding of gene-environment interactions will inform more effective risk-reducing interventions for this vulnerable population.Harriet CullenSaskia SelzamKonstantina DimitrakopoulouRobert PlominA. David EdwardsNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Harriet Cullen Saskia Selzam Konstantina Dimitrakopoulou Robert Plomin A. David Edwards Greater genetic risk for adult psychiatric diseases increases vulnerability to adverse outcome after preterm birth
description	Abstract Preterm birth is an extreme environmental stress associated with an increased risk of later cognitive dysfunction and mental health problems. However, the extent to which preterm birth is modulated by genetic variation remains largely unclear. Here, we test for an interaction effect between psychiatric polygenic risk and gestational age at birth on cognition at age four. Our sample comprises 4934 unrelated individuals (2066 individuals born < 37 weeks, 918 born < = 34 weeks). Genome-wide polygenic scores (GPS’s) were calculated for each individual for five different psychiatric pathologies: Schizophrenia, Bipolar Disorder, Major Depressive Disorder, Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorder. Linear regression modelling was used to estimate the interaction effect between psychiatric GPS and gestational age at birth (GA) on cognitive outcome for the five psychiatric disorders. We found a significant interaction effect between Schizophrenia GPS and GA (β = 0.038 ± 0.013, p = 6.85 × 10–3) and Bipolar Disorder GPS and GA (β = 0.038 ± 0.014, p = 6.61 × 10–3) on cognitive outcome. Individuals with greater genetic risk for Schizophrenia or Bipolar Disorder are more vulnerable to the adverse effects of birth at early gestational age on brain development, as assessed by cognition at age four. Better understanding of gene-environment interactions will inform more effective risk-reducing interventions for this vulnerable population.
format	article
author	Harriet Cullen Saskia Selzam Konstantina Dimitrakopoulou Robert Plomin A. David Edwards
author_facet	Harriet Cullen Saskia Selzam Konstantina Dimitrakopoulou Robert Plomin A. David Edwards
author_sort	Harriet Cullen
title	Greater genetic risk for adult psychiatric diseases increases vulnerability to adverse outcome after preterm birth
title_short	Greater genetic risk for adult psychiatric diseases increases vulnerability to adverse outcome after preterm birth
title_full	Greater genetic risk for adult psychiatric diseases increases vulnerability to adverse outcome after preterm birth
title_fullStr	Greater genetic risk for adult psychiatric diseases increases vulnerability to adverse outcome after preterm birth
title_full_unstemmed	Greater genetic risk for adult psychiatric diseases increases vulnerability to adverse outcome after preterm birth
title_sort	greater genetic risk for adult psychiatric diseases increases vulnerability to adverse outcome after preterm birth
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6f1c454b3c8d4dee9a7239b728a4f0df
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Greater genetic risk for adult psychiatric diseases increases vulnerability to adverse outcome after preterm birth

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