Relationship of breast volume, obesity and central obesity with different prognostic factors of breast cancer

Abstract The objective of this study was to investigate whether the BC tumor biology in women with larger breast volume, in obese women and especially in women with central adiposity at the moment of diagnosis of BC is more aggressive than in those women without these characteristics. 347 pre- and p...

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Autores principales:	Daniel María Lubián López, Carmen Aisha Butrón Hinojo, María Castillo Lara, Manuel Sánchez-Prieto, Rafael Sánchez-Borrego, Nicolas Mendoza Ladrón de Guevara, Ernesto González Mesa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6f1e7adff84b4cfba949366c619ba47f
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spelling	oai:doaj.org-article:6f1e7adff84b4cfba949366c619ba47f2021-12-02T13:56:48ZRelationship of breast volume, obesity and central obesity with different prognostic factors of breast cancer10.1038/s41598-021-81436-92045-2322https://doaj.org/article/6f1e7adff84b4cfba949366c619ba47f2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81436-9https://doaj.org/toc/2045-2322Abstract The objective of this study was to investigate whether the BC tumor biology in women with larger breast volume, in obese women and especially in women with central adiposity at the moment of diagnosis of BC is more aggressive than in those women without these characteristics. 347 pre- and postmenopausal women with a recent diagnosis of BC were analyzed. In all patients, anthropometric measurements at the time of diagnosis was collected. In 103 of them, the breast volume was measured by the Archimedes method. The Breast volume, BMI, WHR and the menopausal status were related to different well-known pathological prognostic factors for BC. At the time of diagnosis, 35.4% were obese (BMI > 30 kg/m2), 60.2% had a WHR ≥ 0.85, 68.8% were postmenopausal and 44.7% had a breast volume considered "large" (> 600 cc). Between patients with a large breast volume, only a higher prevalence of ER (+) tumors was found (95.3% vs. 77.2%; p = 0.04) compared to those with small breast volumes. The obese BC patients showed significantly higher rates of large tumors (45.5% vs. 40.6%; p = 0.04), axillary invasion (53.6% vs. 38.8%; p = 0.04), undifferentiated tumors (38.2% vs. 23.2%) and unfavorable NPI (p = 0.04) than non-obese women. Those with WHR ≥ 0.85 presented higher postsurgical tumor stages (61.7% vs. 57.8%; p = 0.03), higher axillary invasion (39.9% vs. 36.0%; p = 0.004), more undifferentiated tumors (30.0% vs. 22.3%; p = 0.009), higher lymphovascular infiltration (6.5% vs. 1.6%; p = 0.02), and a higher NPI (3.6 ± 1.8 vs. 3.2 ± 1.8; p = 0.04). No statistically significant differences were found according to menopausal status. We conclude that obesity, but especially central obesity can be associated with a more aggressive tumour phenotype. No relation between breast volume and tumoral prognostic factors was found, except for a higher proportion of ER (+) tumor in women with higher breast volume.Daniel María Lubián LópezCarmen Aisha Butrón HinojoMaría Castillo LaraManuel Sánchez-PrietoRafael Sánchez-BorregoNicolas Mendoza Ladrón de GuevaraErnesto González MesaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daniel María Lubián López Carmen Aisha Butrón Hinojo María Castillo Lara Manuel Sánchez-Prieto Rafael Sánchez-Borrego Nicolas Mendoza Ladrón de Guevara Ernesto González Mesa Relationship of breast volume, obesity and central obesity with different prognostic factors of breast cancer
description	Abstract The objective of this study was to investigate whether the BC tumor biology in women with larger breast volume, in obese women and especially in women with central adiposity at the moment of diagnosis of BC is more aggressive than in those women without these characteristics. 347 pre- and postmenopausal women with a recent diagnosis of BC were analyzed. In all patients, anthropometric measurements at the time of diagnosis was collected. In 103 of them, the breast volume was measured by the Archimedes method. The Breast volume, BMI, WHR and the menopausal status were related to different well-known pathological prognostic factors for BC. At the time of diagnosis, 35.4% were obese (BMI > 30 kg/m2), 60.2% had a WHR ≥ 0.85, 68.8% were postmenopausal and 44.7% had a breast volume considered "large" (> 600 cc). Between patients with a large breast volume, only a higher prevalence of ER (+) tumors was found (95.3% vs. 77.2%; p = 0.04) compared to those with small breast volumes. The obese BC patients showed significantly higher rates of large tumors (45.5% vs. 40.6%; p = 0.04), axillary invasion (53.6% vs. 38.8%; p = 0.04), undifferentiated tumors (38.2% vs. 23.2%) and unfavorable NPI (p = 0.04) than non-obese women. Those with WHR ≥ 0.85 presented higher postsurgical tumor stages (61.7% vs. 57.8%; p = 0.03), higher axillary invasion (39.9% vs. 36.0%; p = 0.004), more undifferentiated tumors (30.0% vs. 22.3%; p = 0.009), higher lymphovascular infiltration (6.5% vs. 1.6%; p = 0.02), and a higher NPI (3.6 ± 1.8 vs. 3.2 ± 1.8; p = 0.04). No statistically significant differences were found according to menopausal status. We conclude that obesity, but especially central obesity can be associated with a more aggressive tumour phenotype. No relation between breast volume and tumoral prognostic factors was found, except for a higher proportion of ER (+) tumor in women with higher breast volume.
format	article
author	Daniel María Lubián López Carmen Aisha Butrón Hinojo María Castillo Lara Manuel Sánchez-Prieto Rafael Sánchez-Borrego Nicolas Mendoza Ladrón de Guevara Ernesto González Mesa
author_facet	Daniel María Lubián López Carmen Aisha Butrón Hinojo María Castillo Lara Manuel Sánchez-Prieto Rafael Sánchez-Borrego Nicolas Mendoza Ladrón de Guevara Ernesto González Mesa
author_sort	Daniel María Lubián López
title	Relationship of breast volume, obesity and central obesity with different prognostic factors of breast cancer
title_short	Relationship of breast volume, obesity and central obesity with different prognostic factors of breast cancer
title_full	Relationship of breast volume, obesity and central obesity with different prognostic factors of breast cancer
title_fullStr	Relationship of breast volume, obesity and central obesity with different prognostic factors of breast cancer
title_full_unstemmed	Relationship of breast volume, obesity and central obesity with different prognostic factors of breast cancer
title_sort	relationship of breast volume, obesity and central obesity with different prognostic factors of breast cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6f1e7adff84b4cfba949366c619ba47f
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Relationship of breast volume, obesity and central obesity with different prognostic factors of breast cancer

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