Optogenetic regulation of endogenous proteins

Optogenetic approaches to control protein-protein interactions usually require overexpression of the target proteins. Here the authors integrate intrabodies into near-infrared- and blue-light activatable optogenetic tools to control endogenous proteins in mammalian cells.

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Autores principales:	Taras A. Redchuk, Maksim M. Karasev, Polina V. Verkhusha, Sara K. Donnelly, Maren Hülsemann, Jori Virtanen, Henna M. Moore, Maria K. Vartiainen, Louis Hodgson, Vladislav V. Verkhusha
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6f20a13284cc4e2a9ddb3638c37c57ca
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spelling	oai:doaj.org-article:6f20a13284cc4e2a9ddb3638c37c57ca2021-12-02T15:37:12ZOptogenetic regulation of endogenous proteins10.1038/s41467-020-14460-42041-1723https://doaj.org/article/6f20a13284cc4e2a9ddb3638c37c57ca2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14460-4https://doaj.org/toc/2041-1723Optogenetic approaches to control protein-protein interactions usually require overexpression of the target proteins. Here the authors integrate intrabodies into near-infrared- and blue-light activatable optogenetic tools to control endogenous proteins in mammalian cells.Taras A. RedchukMaksim M. KarasevPolina V. VerkhushaSara K. DonnellyMaren HülsemannJori VirtanenHenna M. MooreMaria K. VartiainenLouis HodgsonVladislav V. VerkhushaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Taras A. Redchuk Maksim M. Karasev Polina V. Verkhusha Sara K. Donnelly Maren Hülsemann Jori Virtanen Henna M. Moore Maria K. Vartiainen Louis Hodgson Vladislav V. Verkhusha Optogenetic regulation of endogenous proteins
description	Optogenetic approaches to control protein-protein interactions usually require overexpression of the target proteins. Here the authors integrate intrabodies into near-infrared- and blue-light activatable optogenetic tools to control endogenous proteins in mammalian cells.
format	article
author	Taras A. Redchuk Maksim M. Karasev Polina V. Verkhusha Sara K. Donnelly Maren Hülsemann Jori Virtanen Henna M. Moore Maria K. Vartiainen Louis Hodgson Vladislav V. Verkhusha
author_facet	Taras A. Redchuk Maksim M. Karasev Polina V. Verkhusha Sara K. Donnelly Maren Hülsemann Jori Virtanen Henna M. Moore Maria K. Vartiainen Louis Hodgson Vladislav V. Verkhusha
author_sort	Taras A. Redchuk
title	Optogenetic regulation of endogenous proteins
title_short	Optogenetic regulation of endogenous proteins
title_full	Optogenetic regulation of endogenous proteins
title_fullStr	Optogenetic regulation of endogenous proteins
title_full_unstemmed	Optogenetic regulation of endogenous proteins
title_sort	optogenetic regulation of endogenous proteins
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6f20a13284cc4e2a9ddb3638c37c57ca
work_keys_str_mv	AT tarasaredchuk optogeneticregulationofendogenousproteins AT maksimmkarasev optogeneticregulationofendogenousproteins AT polinavverkhusha optogeneticregulationofendogenousproteins AT sarakdonnelly optogeneticregulationofendogenousproteins AT marenhulsemann optogeneticregulationofendogenousproteins AT jorivirtanen optogeneticregulationofendogenousproteins AT hennammoore optogeneticregulationofendogenousproteins AT mariakvartiainen optogeneticregulationofendogenousproteins AT louishodgson optogeneticregulationofendogenousproteins AT vladislavvverkhusha optogeneticregulationofendogenousproteins
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Optogenetic regulation of endogenous proteins

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