Aldose reductase inhibitor increases doxorubicin-sensitivity of colon cancer cells and decreases cardiotoxicity

Abstract Anthracycline drugs such as doxorubicin (DOX) and daunorubicin remain some of the most active wide-spectrum and cost-effective drugs in cancer therapy. However, colorectal cancer (CRC) cells are inherently resistant to anthracyclines which at higher doses cause cardiotoxicity. Our recent st...

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Autores principales: Himangshu Sonowal, Pabitra B. Pal, Jian-Jun Wen, Sanjay Awasthi, Kota V. Ramana, Satish K. Srivastava
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/6f2463b6cece423cb821de61b7c4f45e
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