Association between decreased ovarian reserve and poor oocyte quality

Objective To analyze the association between oocyte quality and decreased ovarian reserve (DOR) markers in young women undergoing controlled ovarian stimulation (COS). Methods This retrospective study included 49 patients classified as having DOR based on anti-Müllerian hormone (AMH) levels, follicl...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Viviane Margareth Scantamburlo, Renate von Linsingen, Lidio Jair Ribas Centa, Kahisa Fontana Dal Toso, Debora Scaraboto, Edward Araujo Júnior, Jaime Kulak Junior
Formato:	article
Lenguaje:	EN KO
Publicado:	Korean Society of Obstetrics and Gynecology 2021
Materias:	infertility oocyte quality ovarian reserve controlled ovarian stimulation decreased ovarian reserve Gynecology and obstetrics RG1-991
Acceso en línea:	https://doaj.org/article/6f24ffc10216471a8d3190c27984dccf
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6f24ffc10216471a8d3190c27984dccf
record_format	dspace
spelling	oai:doaj.org-article:6f24ffc10216471a8d3190c27984dccf2021-11-15T00:50:16ZAssociation between decreased ovarian reserve and poor oocyte quality2287-85722287-858010.5468/ogs.20168https://doaj.org/article/6f24ffc10216471a8d3190c27984dccf2021-11-01T00:00:00Zhttp://www.ogscience.org/upload/pdf/ogs-20168.pdfhttps://doaj.org/toc/2287-8572https://doaj.org/toc/2287-8580Objective To analyze the association between oocyte quality and decreased ovarian reserve (DOR) markers in young women undergoing controlled ovarian stimulation (COS). Methods This retrospective study included 49 patients classified as having DOR based on anti-Müllerian hormone (AMH) levels, follicle-stimulating hormone (FSH) levels, or antral follicle counts (AFCs; <10). Images of all obtained oocytes were analyzed, and oocyte quality was classified according to maturity and morphology. The COS protocol utilized gonadotropin (FSH and/or human menopausal gonadotropin [hMG]) doses ranging from 150 to 300 IU/day. The Student’s t test or Mann-Whitney test was used to compare the groups. Spearman’s coefficients were estimated to verify the correlation between the administered dose of FSH/hMG and the number of mature oocytes. To evaluate the association between patient- and oocyte-related variables, logistic regression models were adjusted. Results Women with DOR classified according to FSH level had more immature oocytes (P<0.001). Women with DOR according to AMH had fewer mature oocytes and increased basal FSH levels (P<0.001). Women with DOR according to AFC had an increased risk of abnormally shaped oocytes (P=0.035). Conclusion This study showed that DOR based on AMH levels, FSH levels, and AFC was associated with poorer quality oocytes in young women who underwent COS.Viviane Margareth ScantamburloRenate von LinsingenLidio Jair Ribas CentaKahisa Fontana Dal TosoDebora ScarabotoEdward Araujo JúniorJaime Kulak JuniorKorean Society of Obstetrics and Gynecologyarticleinfertilityoocyte qualityovarian reservecontrolled ovarian stimulationdecreased ovarian reserveGynecology and obstetricsRG1-991ENKOObstetrics & Gynecology Science, Vol 64, Iss 6, Pp 532-539 (2021)
institution	DOAJ
collection	DOAJ
language	EN KO
topic	infertility oocyte quality ovarian reserve controlled ovarian stimulation decreased ovarian reserve Gynecology and obstetrics RG1-991
spellingShingle	infertility oocyte quality ovarian reserve controlled ovarian stimulation decreased ovarian reserve Gynecology and obstetrics RG1-991 Viviane Margareth Scantamburlo Renate von Linsingen Lidio Jair Ribas Centa Kahisa Fontana Dal Toso Debora Scaraboto Edward Araujo Júnior Jaime Kulak Junior Association between decreased ovarian reserve and poor oocyte quality
description	Objective To analyze the association between oocyte quality and decreased ovarian reserve (DOR) markers in young women undergoing controlled ovarian stimulation (COS). Methods This retrospective study included 49 patients classified as having DOR based on anti-Müllerian hormone (AMH) levels, follicle-stimulating hormone (FSH) levels, or antral follicle counts (AFCs; <10). Images of all obtained oocytes were analyzed, and oocyte quality was classified according to maturity and morphology. The COS protocol utilized gonadotropin (FSH and/or human menopausal gonadotropin [hMG]) doses ranging from 150 to 300 IU/day. The Student’s t test or Mann-Whitney test was used to compare the groups. Spearman’s coefficients were estimated to verify the correlation between the administered dose of FSH/hMG and the number of mature oocytes. To evaluate the association between patient- and oocyte-related variables, logistic regression models were adjusted. Results Women with DOR classified according to FSH level had more immature oocytes (P<0.001). Women with DOR according to AMH had fewer mature oocytes and increased basal FSH levels (P<0.001). Women with DOR according to AFC had an increased risk of abnormally shaped oocytes (P=0.035). Conclusion This study showed that DOR based on AMH levels, FSH levels, and AFC was associated with poorer quality oocytes in young women who underwent COS.
format	article
author	Viviane Margareth Scantamburlo Renate von Linsingen Lidio Jair Ribas Centa Kahisa Fontana Dal Toso Debora Scaraboto Edward Araujo Júnior Jaime Kulak Junior
author_facet	Viviane Margareth Scantamburlo Renate von Linsingen Lidio Jair Ribas Centa Kahisa Fontana Dal Toso Debora Scaraboto Edward Araujo Júnior Jaime Kulak Junior
author_sort	Viviane Margareth Scantamburlo
title	Association between decreased ovarian reserve and poor oocyte quality
title_short	Association between decreased ovarian reserve and poor oocyte quality
title_full	Association between decreased ovarian reserve and poor oocyte quality
title_fullStr	Association between decreased ovarian reserve and poor oocyte quality
title_full_unstemmed	Association between decreased ovarian reserve and poor oocyte quality
title_sort	association between decreased ovarian reserve and poor oocyte quality
publisher	Korean Society of Obstetrics and Gynecology
publishDate	2021
url	https://doaj.org/article/6f24ffc10216471a8d3190c27984dccf
work_keys_str_mv	AT vivianemargarethscantamburlo associationbetweendecreasedovarianreserveandpooroocytequality AT renatevonlinsingen associationbetweendecreasedovarianreserveandpooroocytequality AT lidiojairribascenta associationbetweendecreasedovarianreserveandpooroocytequality AT kahisafontanadaltoso associationbetweendecreasedovarianreserveandpooroocytequality AT deborascaraboto associationbetweendecreasedovarianreserveandpooroocytequality AT edwardaraujojunior associationbetweendecreasedovarianreserveandpooroocytequality AT jaimekulakjunior associationbetweendecreasedovarianreserveandpooroocytequality
_version_	1718428991116804096

Association between decreased ovarian reserve and poor oocyte quality

Ejemplares similares