Oxidative coupling of sp 2 and sp 3 carbon–hydrogen bonds to construct dihydrobenzofurans

Cross-dehydrogenative coupling is finding increasing application in synthesis, but coupling two chemically distinct sites remains a challenge. Here, the authors report an oxidative coupling between sp 2 and sp 3 carbons by sequentially activating the more active aryl site followed by the alkyl posit...

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Autores principales: Jiang-Ling Shi, Ding Wang, Xi-Sha Zhang, Xiao-Lei Li, Yu-Qin Chen, Yu-Xue Li, Zhang-Jie Shi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/6f27296a57c8467b9bc947ba878315a6
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Sumario:Cross-dehydrogenative coupling is finding increasing application in synthesis, but coupling two chemically distinct sites remains a challenge. Here, the authors report an oxidative coupling between sp 2 and sp 3 carbons by sequentially activating the more active aryl site followed by the alkyl position.