3D virtual reconstruction and quantitative assessment of the human intervertebral disc’s annulus fibrosus: a DTI tractography study

Abstract The intervertebral disc’s (IVD) annulus fibrosus (AF) retains the hydrostatic pressure of the nucleus pulposus (NP), controls the range of motion, and maintains the integrity of the motion segment. The microstructure of the AF is not yet fully understood and quantitative characterization is...

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Autores principales:	Dan Stein, Yaniv Assaf, Gali Dar, Haim Cohen, Viviane Slon, Einat Kedar, Bahaa Medlej, Janan Abbas, Ori Hay, Daniel Barazany, Israel Hershkovitz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6f281071069a4e819e5a05a18627d6d1
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spelling	oai:doaj.org-article:6f281071069a4e819e5a05a18627d6d12021-12-02T11:45:00Z3D virtual reconstruction and quantitative assessment of the human intervertebral disc’s annulus fibrosus: a DTI tractography study10.1038/s41598-021-86334-82045-2322https://doaj.org/article/6f281071069a4e819e5a05a18627d6d12021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86334-8https://doaj.org/toc/2045-2322Abstract The intervertebral disc’s (IVD) annulus fibrosus (AF) retains the hydrostatic pressure of the nucleus pulposus (NP), controls the range of motion, and maintains the integrity of the motion segment. The microstructure of the AF is not yet fully understood and quantitative characterization is lacking, leaving a caveat in modern medicine’s ability to prevent and treat disc failure (e.g., disc herniation). In this study, we show a reconstruction of the 3D microstructure of the fibers that constitute the AF via MRI diffusion tensor imaging (DTI) followed by fiber tracking. A quantitative analysis presents an anisotropic structure with significant architectural differences among the annuli along the width of the fibrous belt. These findings indicate that the outer annuli's construction reinforces the IVD while providing a sufficient degree of motion. Our findings also suggest an increased role of the outer annuli in IVD nourishment.Dan SteinYaniv AssafGali DarHaim CohenViviane SlonEinat KedarBahaa MedlejJanan AbbasOri HayDaniel BarazanyIsrael HershkovitzNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dan Stein Yaniv Assaf Gali Dar Haim Cohen Viviane Slon Einat Kedar Bahaa Medlej Janan Abbas Ori Hay Daniel Barazany Israel Hershkovitz 3D virtual reconstruction and quantitative assessment of the human intervertebral disc’s annulus fibrosus: a DTI tractography study
description	Abstract The intervertebral disc’s (IVD) annulus fibrosus (AF) retains the hydrostatic pressure of the nucleus pulposus (NP), controls the range of motion, and maintains the integrity of the motion segment. The microstructure of the AF is not yet fully understood and quantitative characterization is lacking, leaving a caveat in modern medicine’s ability to prevent and treat disc failure (e.g., disc herniation). In this study, we show a reconstruction of the 3D microstructure of the fibers that constitute the AF via MRI diffusion tensor imaging (DTI) followed by fiber tracking. A quantitative analysis presents an anisotropic structure with significant architectural differences among the annuli along the width of the fibrous belt. These findings indicate that the outer annuli's construction reinforces the IVD while providing a sufficient degree of motion. Our findings also suggest an increased role of the outer annuli in IVD nourishment.
format	article
author	Dan Stein Yaniv Assaf Gali Dar Haim Cohen Viviane Slon Einat Kedar Bahaa Medlej Janan Abbas Ori Hay Daniel Barazany Israel Hershkovitz
author_facet	Dan Stein Yaniv Assaf Gali Dar Haim Cohen Viviane Slon Einat Kedar Bahaa Medlej Janan Abbas Ori Hay Daniel Barazany Israel Hershkovitz
author_sort	Dan Stein
title	3D virtual reconstruction and quantitative assessment of the human intervertebral disc’s annulus fibrosus: a DTI tractography study
title_short	3D virtual reconstruction and quantitative assessment of the human intervertebral disc’s annulus fibrosus: a DTI tractography study
title_full	3D virtual reconstruction and quantitative assessment of the human intervertebral disc’s annulus fibrosus: a DTI tractography study
title_fullStr	3D virtual reconstruction and quantitative assessment of the human intervertebral disc’s annulus fibrosus: a DTI tractography study
title_full_unstemmed	3D virtual reconstruction and quantitative assessment of the human intervertebral disc’s annulus fibrosus: a DTI tractography study
title_sort	3d virtual reconstruction and quantitative assessment of the human intervertebral disc’s annulus fibrosus: a dti tractography study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6f281071069a4e819e5a05a18627d6d1
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3D virtual reconstruction and quantitative assessment of the human intervertebral disc’s annulus fibrosus: a DTI tractography study

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