Risk factors for HPV infection and high-grade cervical disease in sexually active Japanese women

Abstract In Japan, recommendations for HPV vaccines were suspended in 2013 due to unfounded safety fears. Although vaccine opponents claim modifying sexual behavior can prevent cervical cancer, no comprehensive data exist on sexual behavior and the risk of high-grade cervical disease in a Japanese p...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Manako Yamaguchi, Masayuki Sekine, Sharon J. B. Hanley, Risa Kudo, Megumi Hara, Sosuke Adachi, Yutaka Ueda, Etsuko Miyagi, Takayuki Enomoto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6f2b048b99224590a31e35282b94236a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6f2b048b99224590a31e35282b94236a
record_format	dspace
spelling	oai:doaj.org-article:6f2b048b99224590a31e35282b94236a2021-12-02T14:06:19ZRisk factors for HPV infection and high-grade cervical disease in sexually active Japanese women10.1038/s41598-021-82354-62045-2322https://doaj.org/article/6f2b048b99224590a31e35282b94236a2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82354-6https://doaj.org/toc/2045-2322Abstract In Japan, recommendations for HPV vaccines were suspended in 2013 due to unfounded safety fears. Although vaccine opponents claim modifying sexual behavior can prevent cervical cancer, no comprehensive data exist on sexual behavior and the risk of high-grade cervical disease in a Japanese population. This study investigates sexual behavior and the risk of HPV infection and cervical disease in 3968 women aged 20–41 yrs undergoing cervical screening between April 2014 and March 2016. Mean age at first intercourse was 18.4 yrs ± 2.8 and 32% of women reported ≥ 6 lifetime sexual partners. In regression analyses, number of partners was a significant risk factor for HPV infection. However, for high-grade disease (CIN2+), when HPV genotype was adjusted for, number of partners was not statistically significant. The greatest risk factor was an HPV16/18 infection (adjusted odds ratio 113.7, 95% CI: 40.8–316.9). In conclusion, we found that having an HPV16/18 infection and not sexual behavior was the most significant risk factor for high grade cervical disease in young Japanese women. These infections can be prevented by a highly effective vaccine and we recommend that the Japanese government resume proactive recommendations for the HPV vaccine immediately.Manako YamaguchiMasayuki SekineSharon J. B. HanleyRisa KudoMegumi HaraSosuke AdachiYutaka UedaEtsuko MiyagiTakayuki EnomotoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Manako Yamaguchi Masayuki Sekine Sharon J. B. Hanley Risa Kudo Megumi Hara Sosuke Adachi Yutaka Ueda Etsuko Miyagi Takayuki Enomoto Risk factors for HPV infection and high-grade cervical disease in sexually active Japanese women
description	Abstract In Japan, recommendations for HPV vaccines were suspended in 2013 due to unfounded safety fears. Although vaccine opponents claim modifying sexual behavior can prevent cervical cancer, no comprehensive data exist on sexual behavior and the risk of high-grade cervical disease in a Japanese population. This study investigates sexual behavior and the risk of HPV infection and cervical disease in 3968 women aged 20–41 yrs undergoing cervical screening between April 2014 and March 2016. Mean age at first intercourse was 18.4 yrs ± 2.8 and 32% of women reported ≥ 6 lifetime sexual partners. In regression analyses, number of partners was a significant risk factor for HPV infection. However, for high-grade disease (CIN2+), when HPV genotype was adjusted for, number of partners was not statistically significant. The greatest risk factor was an HPV16/18 infection (adjusted odds ratio 113.7, 95% CI: 40.8–316.9). In conclusion, we found that having an HPV16/18 infection and not sexual behavior was the most significant risk factor for high grade cervical disease in young Japanese women. These infections can be prevented by a highly effective vaccine and we recommend that the Japanese government resume proactive recommendations for the HPV vaccine immediately.
format	article
author	Manako Yamaguchi Masayuki Sekine Sharon J. B. Hanley Risa Kudo Megumi Hara Sosuke Adachi Yutaka Ueda Etsuko Miyagi Takayuki Enomoto
author_facet	Manako Yamaguchi Masayuki Sekine Sharon J. B. Hanley Risa Kudo Megumi Hara Sosuke Adachi Yutaka Ueda Etsuko Miyagi Takayuki Enomoto
author_sort	Manako Yamaguchi
title	Risk factors for HPV infection and high-grade cervical disease in sexually active Japanese women
title_short	Risk factors for HPV infection and high-grade cervical disease in sexually active Japanese women
title_full	Risk factors for HPV infection and high-grade cervical disease in sexually active Japanese women
title_fullStr	Risk factors for HPV infection and high-grade cervical disease in sexually active Japanese women
title_full_unstemmed	Risk factors for HPV infection and high-grade cervical disease in sexually active Japanese women
title_sort	risk factors for hpv infection and high-grade cervical disease in sexually active japanese women
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6f2b048b99224590a31e35282b94236a
work_keys_str_mv	AT manakoyamaguchi riskfactorsforhpvinfectionandhighgradecervicaldiseaseinsexuallyactivejapanesewomen AT masayukisekine riskfactorsforhpvinfectionandhighgradecervicaldiseaseinsexuallyactivejapanesewomen AT sharonjbhanley riskfactorsforhpvinfectionandhighgradecervicaldiseaseinsexuallyactivejapanesewomen AT risakudo riskfactorsforhpvinfectionandhighgradecervicaldiseaseinsexuallyactivejapanesewomen AT megumihara riskfactorsforhpvinfectionandhighgradecervicaldiseaseinsexuallyactivejapanesewomen AT sosukeadachi riskfactorsforhpvinfectionandhighgradecervicaldiseaseinsexuallyactivejapanesewomen AT yutakaueda riskfactorsforhpvinfectionandhighgradecervicaldiseaseinsexuallyactivejapanesewomen AT etsukomiyagi riskfactorsforhpvinfectionandhighgradecervicaldiseaseinsexuallyactivejapanesewomen AT takayukienomoto riskfactorsforhpvinfectionandhighgradecervicaldiseaseinsexuallyactivejapanesewomen
_version_	1718392026376962048

Risk factors for HPV infection and high-grade cervical disease in sexually active Japanese women

Ejemplares similares