Preparation and characterization of superparamagnetic iron oxide nanoparticles for magnetically guided drug delivery

Pramod Kumar, Shrish Agnihotri, Indrajit Roy Department of Chemistry, University of Delhi, Delhi, India Abstract: Iron oxide nanoparticles have unique magnetic properties and therefore readily respond to applied magnetic fields. Moreover, their surfaces can be used to attach active molecules via v...

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Autores principales:	Kumar P, Agnihotri S, Roy I
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	SPION Dox Dox-CA-SPION magnetically guided delivery Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6f2d7b0421b24d779f0fd760e5ed6d3e
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spelling	oai:doaj.org-article:6f2d7b0421b24d779f0fd760e5ed6d3e2021-12-02T05:39:39ZPreparation and characterization of superparamagnetic iron oxide nanoparticles for magnetically guided drug delivery1178-2013https://doaj.org/article/6f2d7b0421b24d779f0fd760e5ed6d3e2018-03-01T00:00:00Zhttps://www.dovepress.com/preparation-and-characterization-of-superparamagnetic-iron-oxide-nanop-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Pramod Kumar, Shrish Agnihotri, Indrajit Roy Department of Chemistry, University of Delhi, Delhi, India Abstract: Iron oxide nanoparticles have unique magnetic properties and therefore readily respond to applied magnetic fields. Moreover, their surfaces can be used to attach active molecules via various covalent or noncovalent interactions. Thus, they can be used as drug carriers for magnetically controlled delivery to specific biological sites of interest. In the present study, we have synthesized aqueous dispersed samples of citric acid-capped iron oxide nanoparticles, and the anticancer drug doxorubicin was then linked with these superparamagnetic iron oxide nanoparticles via a simple noncovalent interaction. Our results show that the conjugated drug releases from the nanoparticles in a sustained manner. The cellular uptake of these nanoparticles was found to be substantial, although it can be further enhanced using magnetic guidance. These nanoparticles (drug free) were found to be nontoxic to cells; however, upon drug conjugation, drug-induced toxicity was observed, owing to the slow release of drug from the nanoparticles. Keywords: SPION, Dox, Dox-CA-SPION, magnetically guided deliveryKumar PAgnihotri SRoy IDove Medical PressarticleSPIONDoxDox-CA-SPIONmagnetically guided deliveryMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 43-46 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	SPION Dox Dox-CA-SPION magnetically guided delivery Medicine (General) R5-920
spellingShingle	SPION Dox Dox-CA-SPION magnetically guided delivery Medicine (General) R5-920 Kumar P Agnihotri S Roy I Preparation and characterization of superparamagnetic iron oxide nanoparticles for magnetically guided drug delivery
description	Pramod Kumar, Shrish Agnihotri, Indrajit Roy Department of Chemistry, University of Delhi, Delhi, India Abstract: Iron oxide nanoparticles have unique magnetic properties and therefore readily respond to applied magnetic fields. Moreover, their surfaces can be used to attach active molecules via various covalent or noncovalent interactions. Thus, they can be used as drug carriers for magnetically controlled delivery to specific biological sites of interest. In the present study, we have synthesized aqueous dispersed samples of citric acid-capped iron oxide nanoparticles, and the anticancer drug doxorubicin was then linked with these superparamagnetic iron oxide nanoparticles via a simple noncovalent interaction. Our results show that the conjugated drug releases from the nanoparticles in a sustained manner. The cellular uptake of these nanoparticles was found to be substantial, although it can be further enhanced using magnetic guidance. These nanoparticles (drug free) were found to be nontoxic to cells; however, upon drug conjugation, drug-induced toxicity was observed, owing to the slow release of drug from the nanoparticles. Keywords: SPION, Dox, Dox-CA-SPION, magnetically guided delivery
format	article
author	Kumar P Agnihotri S Roy I
author_facet	Kumar P Agnihotri S Roy I
author_sort	Kumar P
title	Preparation and characterization of superparamagnetic iron oxide nanoparticles for magnetically guided drug delivery
title_short	Preparation and characterization of superparamagnetic iron oxide nanoparticles for magnetically guided drug delivery
title_full	Preparation and characterization of superparamagnetic iron oxide nanoparticles for magnetically guided drug delivery
title_fullStr	Preparation and characterization of superparamagnetic iron oxide nanoparticles for magnetically guided drug delivery
title_full_unstemmed	Preparation and characterization of superparamagnetic iron oxide nanoparticles for magnetically guided drug delivery
title_sort	preparation and characterization of superparamagnetic iron oxide nanoparticles for magnetically guided drug delivery
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/6f2d7b0421b24d779f0fd760e5ed6d3e
work_keys_str_mv	AT kumarp preparationandcharacterizationofsuperparamagneticironoxidenanoparticlesformagneticallyguideddrugdelivery AT agnihotris preparationandcharacterizationofsuperparamagneticironoxidenanoparticlesformagneticallyguideddrugdelivery AT royi preparationandcharacterizationofsuperparamagneticironoxidenanoparticlesformagneticallyguideddrugdelivery
_version_	1718400303058911232

Preparation and characterization of superparamagnetic iron oxide nanoparticles for magnetically guided drug delivery

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