Redox Dysregulation in Aging and COPD: Role of NOX Enzymes and Implications for Antioxidant Strategies

With a rapidly growing elderly human population, the incidence of age-related lung diseases such as chronic obstructive pulmonary disease (COPD) continues to rise. It is widely believed that reactive oxygen species (ROS) play an important role in ageing and in age-related disease, and approaches of...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Caspar Schiffers, Niki L. Reynaert, Emiel F. M. Wouters, Albert van der Vliet
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	ageing COPD oxidative stress redox signalling NADPH oxidase DUOX1 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/6f3022a396f0489db2db729818152b76
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6f3022a396f0489db2db729818152b76
record_format	dspace
spelling	oai:doaj.org-article:6f3022a396f0489db2db729818152b762021-11-25T16:28:48ZRedox Dysregulation in Aging and COPD: Role of NOX Enzymes and Implications for Antioxidant Strategies10.3390/antiox101117992076-3921https://doaj.org/article/6f3022a396f0489db2db729818152b762021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1799https://doaj.org/toc/2076-3921With a rapidly growing elderly human population, the incidence of age-related lung diseases such as chronic obstructive pulmonary disease (COPD) continues to rise. It is widely believed that reactive oxygen species (ROS) play an important role in ageing and in age-related disease, and approaches of antioxidant supplementation have been touted as useful strategies to mitigate age-related disease progression, although success of such strategies has been very limited to date. Involvement of ROS in ageing is largely attributed to mitochondrial dysfunction and impaired adaptive antioxidant responses. NADPH oxidase (NOX) enzymes represent an important enzyme family that generates ROS in a regulated fashion for purposes of oxidative host defense and redox-based signalling, however, the associations of NOX enzymes with lung ageing or age-related lung disease have to date only been minimally addressed. The present review will focus on our current understanding of the impact of ageing on NOX biology and its consequences for age-related lung disease, particularly COPD, and will also discuss the implications of altered NOX biology for current and future antioxidant-based strategies aimed at treating these diseases.Caspar SchiffersNiki L. ReynaertEmiel F. M. WoutersAlbert van der VlietMDPI AGarticleageingCOPDoxidative stressredox signallingNADPH oxidaseDUOX1Therapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1799, p 1799 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ageing COPD oxidative stress redox signalling NADPH oxidase DUOX1 Therapeutics. Pharmacology RM1-950
spellingShingle	ageing COPD oxidative stress redox signalling NADPH oxidase DUOX1 Therapeutics. Pharmacology RM1-950 Caspar Schiffers Niki L. Reynaert Emiel F. M. Wouters Albert van der Vliet Redox Dysregulation in Aging and COPD: Role of NOX Enzymes and Implications for Antioxidant Strategies
description	With a rapidly growing elderly human population, the incidence of age-related lung diseases such as chronic obstructive pulmonary disease (COPD) continues to rise. It is widely believed that reactive oxygen species (ROS) play an important role in ageing and in age-related disease, and approaches of antioxidant supplementation have been touted as useful strategies to mitigate age-related disease progression, although success of such strategies has been very limited to date. Involvement of ROS in ageing is largely attributed to mitochondrial dysfunction and impaired adaptive antioxidant responses. NADPH oxidase (NOX) enzymes represent an important enzyme family that generates ROS in a regulated fashion for purposes of oxidative host defense and redox-based signalling, however, the associations of NOX enzymes with lung ageing or age-related lung disease have to date only been minimally addressed. The present review will focus on our current understanding of the impact of ageing on NOX biology and its consequences for age-related lung disease, particularly COPD, and will also discuss the implications of altered NOX biology for current and future antioxidant-based strategies aimed at treating these diseases.
format	article
author	Caspar Schiffers Niki L. Reynaert Emiel F. M. Wouters Albert van der Vliet
author_facet	Caspar Schiffers Niki L. Reynaert Emiel F. M. Wouters Albert van der Vliet
author_sort	Caspar Schiffers
title	Redox Dysregulation in Aging and COPD: Role of NOX Enzymes and Implications for Antioxidant Strategies
title_short	Redox Dysregulation in Aging and COPD: Role of NOX Enzymes and Implications for Antioxidant Strategies
title_full	Redox Dysregulation in Aging and COPD: Role of NOX Enzymes and Implications for Antioxidant Strategies
title_fullStr	Redox Dysregulation in Aging and COPD: Role of NOX Enzymes and Implications for Antioxidant Strategies
title_full_unstemmed	Redox Dysregulation in Aging and COPD: Role of NOX Enzymes and Implications for Antioxidant Strategies
title_sort	redox dysregulation in aging and copd: role of nox enzymes and implications for antioxidant strategies
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6f3022a396f0489db2db729818152b76
work_keys_str_mv	AT casparschiffers redoxdysregulationinagingandcopdroleofnoxenzymesandimplicationsforantioxidantstrategies AT nikilreynaert redoxdysregulationinagingandcopdroleofnoxenzymesandimplicationsforantioxidantstrategies AT emielfmwouters redoxdysregulationinagingandcopdroleofnoxenzymesandimplicationsforantioxidantstrategies AT albertvandervliet redoxdysregulationinagingandcopdroleofnoxenzymesandimplicationsforantioxidantstrategies
_version_	1718413143008346112

Redox Dysregulation in Aging and COPD: Role of NOX Enzymes and Implications for Antioxidant Strategies

Ejemplares similares