INTENSITY OF SPECIFIC SENSITIZATION AND IMMUNE PROFILE IN PATIENTS WITH BRUCELLOSIS
The authors propose a new methodological approach to rapid intensity assessment of specific sensitization in acute brucellosis. This technique shows high sensitivity (98%), and specificity (97%). We revealed a direct relation between the intensity of specific IgE-dependent sensitization accompanied...
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| Main Authors: | , , , , , |
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| Format: | article |
| Language: | RU |
| Published: |
SPb RAACI
2016
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| Subjects: | |
| Online Access: | https://doaj.org/article/6f30d3722b894e22b1d9d45a2b000e2c |
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| Summary: | The authors propose a new methodological approach to rapid intensity assessment of specific sensitization in acute brucellosis. This technique shows high sensitivity (98%), and specificity (97%). We revealed a direct relation between the intensity of specific IgE-dependent sensitization accompanied by development of immunosuppressive state in patients with brucellosis, i.e., a mean reduction of total CD3+ cell counts by 17.9%; CD3+CD4+ cells, by 13.3%; CD16+CD56+, by 4.4%. Phagocytic ability of blood neutrophils was decreased by 25.8%. The study has shown that an increased reagin-dependent sensitization in brucellosis is closely associated with emergence of severe immunosuppression. |
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