INTENSITY OF SPECIFIC SENSITIZATION AND IMMUNE PROFILE IN PATIENTS WITH BRUCELLOSIS

The authors propose a new methodological approach to rapid intensity assessment of specific sensitization in acute brucellosis. This technique shows high sensitivity (98%), and specificity (97%). We revealed a direct relation between the intensity of specific IgE-dependent sensitization accompanied...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	N. S. Sarkisуan, D. G. Ponomarenko, V. O. Logvinenko, E. L. Rakitina, M. V. Kostyuchenko, A. N. Kulichenko
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2016
Materias:	brucellosis in vitro allergodiagnostics basophil activation test immunosuppression Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/6f30d3722b894e22b1d9d45a2b000e2c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6f30d3722b894e22b1d9d45a2b000e2c
record_format	dspace
spelling	oai:doaj.org-article:6f30d3722b894e22b1d9d45a2b000e2c2021-11-18T08:03:45ZINTENSITY OF SPECIFIC SENSITIZATION AND IMMUNE PROFILE IN PATIENTS WITH BRUCELLOSIS1563-06252313-741X10.15789/1563-0625-2016-4-365-372https://doaj.org/article/6f30d3722b894e22b1d9d45a2b000e2c2016-08-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1059https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe authors propose a new methodological approach to rapid intensity assessment of specific sensitization in acute brucellosis. This technique shows high sensitivity (98%), and specificity (97%). We revealed a direct relation between the intensity of specific IgE-dependent sensitization accompanied by development of immunosuppressive state in patients with brucellosis, i.e., a mean reduction of total CD3+ cell counts by 17.9%; CD3+CD4+ cells, by 13.3%; CD16+CD56+, by 4.4%. Phagocytic ability of blood neutrophils was decreased by 25.8%. The study has shown that an increased reagin-dependent sensitization in brucellosis is closely associated with emergence of severe immunosuppression.N. S. SarkisуanD. G. PonomarenkoV. O. LogvinenkoE. L. RakitinaM. V. KostyuchenkoA. N. KulichenkoSPb RAACIarticlebrucellosisin vitro allergodiagnosticsbasophil activation testimmunosuppressionImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 18, Iss 4, Pp 365-372 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	brucellosis in vitro allergodiagnostics basophil activation test immunosuppression Immunologic diseases. Allergy RC581-607
spellingShingle	brucellosis in vitro allergodiagnostics basophil activation test immunosuppression Immunologic diseases. Allergy RC581-607 N. S. Sarkisуan D. G. Ponomarenko V. O. Logvinenko E. L. Rakitina M. V. Kostyuchenko A. N. Kulichenko INTENSITY OF SPECIFIC SENSITIZATION AND IMMUNE PROFILE IN PATIENTS WITH BRUCELLOSIS
description	The authors propose a new methodological approach to rapid intensity assessment of specific sensitization in acute brucellosis. This technique shows high sensitivity (98%), and specificity (97%). We revealed a direct relation between the intensity of specific IgE-dependent sensitization accompanied by development of immunosuppressive state in patients with brucellosis, i.e., a mean reduction of total CD3+ cell counts by 17.9%; CD3+CD4+ cells, by 13.3%; CD16+CD56+, by 4.4%. Phagocytic ability of blood neutrophils was decreased by 25.8%. The study has shown that an increased reagin-dependent sensitization in brucellosis is closely associated with emergence of severe immunosuppression.
format	article
author	N. S. Sarkisуan D. G. Ponomarenko V. O. Logvinenko E. L. Rakitina M. V. Kostyuchenko A. N. Kulichenko
author_facet	N. S. Sarkisуan D. G. Ponomarenko V. O. Logvinenko E. L. Rakitina M. V. Kostyuchenko A. N. Kulichenko
author_sort	N. S. Sarkisуan
title	INTENSITY OF SPECIFIC SENSITIZATION AND IMMUNE PROFILE IN PATIENTS WITH BRUCELLOSIS
title_short	INTENSITY OF SPECIFIC SENSITIZATION AND IMMUNE PROFILE IN PATIENTS WITH BRUCELLOSIS
title_full	INTENSITY OF SPECIFIC SENSITIZATION AND IMMUNE PROFILE IN PATIENTS WITH BRUCELLOSIS
title_fullStr	INTENSITY OF SPECIFIC SENSITIZATION AND IMMUNE PROFILE IN PATIENTS WITH BRUCELLOSIS
title_full_unstemmed	INTENSITY OF SPECIFIC SENSITIZATION AND IMMUNE PROFILE IN PATIENTS WITH BRUCELLOSIS
title_sort	intensity of specific sensitization and immune profile in patients with brucellosis
publisher	SPb RAACI
publishDate	2016
url	https://doaj.org/article/6f30d3722b894e22b1d9d45a2b000e2c
work_keys_str_mv	AT nssarkisuan intensityofspecificsensitizationandimmuneprofileinpatientswithbrucellosis AT dgponomarenko intensityofspecificsensitizationandimmuneprofileinpatientswithbrucellosis AT vologvinenko intensityofspecificsensitizationandimmuneprofileinpatientswithbrucellosis AT elrakitina intensityofspecificsensitizationandimmuneprofileinpatientswithbrucellosis AT mvkostyuchenko intensityofspecificsensitizationandimmuneprofileinpatientswithbrucellosis AT ankulichenko intensityofspecificsensitizationandimmuneprofileinpatientswithbrucellosis
_version_	1718422425307185152

INTENSITY OF SPECIFIC SENSITIZATION AND IMMUNE PROFILE IN PATIENTS WITH BRUCELLOSIS

Ejemplares similares