Stimuli-Responsive Polymeric Nanomaterials for the Delivery of Immunotherapy Moieties: Antigens, Adjuvants and Agonists

Immunotherapy has been investigated for decades, and it has provided promising results in preclinical studies. The most important issue that hinders researchers from advancing to clinical studies is the delivery system for immunotherapy agents, such as antigens, adjuvants and agonists, and the activ...

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Autores principales:	Raveena Nagareddy, Reju George Thomas, Yong Yeon Jeong
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	stimuli polymer nanoparticle tumour microenvironment (TME) cancer immunotherapy Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/6f34fd152d6b40d2839949ecdfe07e64
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spelling	oai:doaj.org-article:6f34fd152d6b40d2839949ecdfe07e642021-11-25T17:57:23ZStimuli-Responsive Polymeric Nanomaterials for the Delivery of Immunotherapy Moieties: Antigens, Adjuvants and Agonists10.3390/ijms2222125101422-00671661-6596https://doaj.org/article/6f34fd152d6b40d2839949ecdfe07e642021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12510https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Immunotherapy has been investigated for decades, and it has provided promising results in preclinical studies. The most important issue that hinders researchers from advancing to clinical studies is the delivery system for immunotherapy agents, such as antigens, adjuvants and agonists, and the activation of these agents at the tumour site. Polymers are among the most versatile materials for a variety of treatments and diagnostics, and some polymers are reactive to either endogenous or exogenous stimuli. Utilizing this advantage, researchers have been developing novel and effective polymeric nanomaterials that can deliver immunotherapeutic moieties. In this review, we summarized recent works on stimuli-responsive polymeric nanomaterials that deliver antigens, adjuvants and agonists to tumours for immunotherapy purposes.Raveena NagareddyReju George ThomasYong Yeon JeongMDPI AGarticlestimulipolymer nanoparticletumour microenvironment (TME)cancer immunotherapyBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12510, p 12510 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	stimuli polymer nanoparticle tumour microenvironment (TME) cancer immunotherapy Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	stimuli polymer nanoparticle tumour microenvironment (TME) cancer immunotherapy Biology (General) QH301-705.5 Chemistry QD1-999 Raveena Nagareddy Reju George Thomas Yong Yeon Jeong Stimuli-Responsive Polymeric Nanomaterials for the Delivery of Immunotherapy Moieties: Antigens, Adjuvants and Agonists
description	Immunotherapy has been investigated for decades, and it has provided promising results in preclinical studies. The most important issue that hinders researchers from advancing to clinical studies is the delivery system for immunotherapy agents, such as antigens, adjuvants and agonists, and the activation of these agents at the tumour site. Polymers are among the most versatile materials for a variety of treatments and diagnostics, and some polymers are reactive to either endogenous or exogenous stimuli. Utilizing this advantage, researchers have been developing novel and effective polymeric nanomaterials that can deliver immunotherapeutic moieties. In this review, we summarized recent works on stimuli-responsive polymeric nanomaterials that deliver antigens, adjuvants and agonists to tumours for immunotherapy purposes.
format	article
author	Raveena Nagareddy Reju George Thomas Yong Yeon Jeong
author_facet	Raveena Nagareddy Reju George Thomas Yong Yeon Jeong
author_sort	Raveena Nagareddy
title	Stimuli-Responsive Polymeric Nanomaterials for the Delivery of Immunotherapy Moieties: Antigens, Adjuvants and Agonists
title_short	Stimuli-Responsive Polymeric Nanomaterials for the Delivery of Immunotherapy Moieties: Antigens, Adjuvants and Agonists
title_full	Stimuli-Responsive Polymeric Nanomaterials for the Delivery of Immunotherapy Moieties: Antigens, Adjuvants and Agonists
title_fullStr	Stimuli-Responsive Polymeric Nanomaterials for the Delivery of Immunotherapy Moieties: Antigens, Adjuvants and Agonists
title_full_unstemmed	Stimuli-Responsive Polymeric Nanomaterials for the Delivery of Immunotherapy Moieties: Antigens, Adjuvants and Agonists
title_sort	stimuli-responsive polymeric nanomaterials for the delivery of immunotherapy moieties: antigens, adjuvants and agonists
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6f34fd152d6b40d2839949ecdfe07e64
work_keys_str_mv	AT raveenanagareddy stimuliresponsivepolymericnanomaterialsforthedeliveryofimmunotherapymoietiesantigensadjuvantsandagonists AT rejugeorgethomas stimuliresponsivepolymericnanomaterialsforthedeliveryofimmunotherapymoietiesantigensadjuvantsandagonists AT yongyeonjeong stimuliresponsivepolymericnanomaterialsforthedeliveryofimmunotherapymoietiesantigensadjuvantsandagonists
_version_	1718411808833798144

Stimuli-Responsive Polymeric Nanomaterials for the Delivery of Immunotherapy Moieties: Antigens, Adjuvants and Agonists

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