Cytotoxicity of synthetic derivatives against breast cancer and multi-drug resistant breast cancer cell lines: a literature-based perspective study

Abstract Cancer is the second most killer worldwide causing millions of people to lose their lives every year. In the case of women, breast cancer takes away the highest proportion of mortality rate than other cancers. Due to the mutation and resistance-building capacity of different breast cancer c...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Shabnam Sharmin, Md. Mizanur Rahaman, Miquel Martorell, Jorge Sastre-Serra, Javad Sharifi-Rad, Monica Butnariu, Iulia Cristina Bagiu, Radu Vasile Bagiu, Mohammad Torequl Islam
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Synthetic derivatives Breast cancer cell line MDR breast cancer cell line Cytotoxicity Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671
Acceso en línea:	https://doaj.org/article/6f3615e2fe814f4ba3589a8ca1bc8259
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6f3615e2fe814f4ba3589a8ca1bc8259
record_format	dspace
spelling	oai:doaj.org-article:6f3615e2fe814f4ba3589a8ca1bc82592021-11-21T12:39:37ZCytotoxicity of synthetic derivatives against breast cancer and multi-drug resistant breast cancer cell lines: a literature-based perspective study10.1186/s12935-021-02309-91475-2867https://doaj.org/article/6f3615e2fe814f4ba3589a8ca1bc82592021-11-01T00:00:00Zhttps://doi.org/10.1186/s12935-021-02309-9https://doaj.org/toc/1475-2867Abstract Cancer is the second most killer worldwide causing millions of people to lose their lives every year. In the case of women, breast cancer takes away the highest proportion of mortality rate than other cancers. Due to the mutation and resistance-building capacity of different breast cancer cell lines against conventional therapies, this death rate is on the verge of growth. New effective therapeutic compounds and treatment method is the best way to look out for in this critical time. For instance, new synthetic derivatives/ analogues synthesized from different compounds can be a ray of hope. Numerous synthetic compounds have been seen enhancing the apoptosis and autophagic pathway that directly exerts cytotoxicity towards different breast cancer cell lines. To cease the ever-growing resistance of multi-drug resistant cells against anti-breast cancer drugs (Doxorubicin, verapamil, tamoxifen) synthetic compounds may play a vital role by increasing effectivity, showing synergistic action. Many recent and previous studies have reported that synthetic derivatives hold potentials as an effective anti-breast cancer agent as they show great cytotoxicity towards cancer cells, thus can be used even vastly in the future in the field of breast cancer treatment. This review aims to identify the anti-breast cancer properties of several synthetic derivatives against different breast cancer and multi-drug-resistant breast cancer cell lines with their reported mechanism of action and effectivity.Shabnam SharminMd. Mizanur RahamanMiquel MartorellJorge Sastre-SerraJavad Sharifi-RadMonica ButnariuIulia Cristina BagiuRadu Vasile BagiuMohammad Torequl IslamBMCarticleSynthetic derivativesBreast cancer cell lineMDR breast cancer cell lineCytotoxicityNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282CytologyQH573-671ENCancer Cell International, Vol 21, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Synthetic derivatives Breast cancer cell line MDR breast cancer cell line Cytotoxicity Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671
spellingShingle	Synthetic derivatives Breast cancer cell line MDR breast cancer cell line Cytotoxicity Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671 Shabnam Sharmin Md. Mizanur Rahaman Miquel Martorell Jorge Sastre-Serra Javad Sharifi-Rad Monica Butnariu Iulia Cristina Bagiu Radu Vasile Bagiu Mohammad Torequl Islam Cytotoxicity of synthetic derivatives against breast cancer and multi-drug resistant breast cancer cell lines: a literature-based perspective study
description	Abstract Cancer is the second most killer worldwide causing millions of people to lose their lives every year. In the case of women, breast cancer takes away the highest proportion of mortality rate than other cancers. Due to the mutation and resistance-building capacity of different breast cancer cell lines against conventional therapies, this death rate is on the verge of growth. New effective therapeutic compounds and treatment method is the best way to look out for in this critical time. For instance, new synthetic derivatives/ analogues synthesized from different compounds can be a ray of hope. Numerous synthetic compounds have been seen enhancing the apoptosis and autophagic pathway that directly exerts cytotoxicity towards different breast cancer cell lines. To cease the ever-growing resistance of multi-drug resistant cells against anti-breast cancer drugs (Doxorubicin, verapamil, tamoxifen) synthetic compounds may play a vital role by increasing effectivity, showing synergistic action. Many recent and previous studies have reported that synthetic derivatives hold potentials as an effective anti-breast cancer agent as they show great cytotoxicity towards cancer cells, thus can be used even vastly in the future in the field of breast cancer treatment. This review aims to identify the anti-breast cancer properties of several synthetic derivatives against different breast cancer and multi-drug-resistant breast cancer cell lines with their reported mechanism of action and effectivity.
format	article
author	Shabnam Sharmin Md. Mizanur Rahaman Miquel Martorell Jorge Sastre-Serra Javad Sharifi-Rad Monica Butnariu Iulia Cristina Bagiu Radu Vasile Bagiu Mohammad Torequl Islam
author_facet	Shabnam Sharmin Md. Mizanur Rahaman Miquel Martorell Jorge Sastre-Serra Javad Sharifi-Rad Monica Butnariu Iulia Cristina Bagiu Radu Vasile Bagiu Mohammad Torequl Islam
author_sort	Shabnam Sharmin
title	Cytotoxicity of synthetic derivatives against breast cancer and multi-drug resistant breast cancer cell lines: a literature-based perspective study
title_short	Cytotoxicity of synthetic derivatives against breast cancer and multi-drug resistant breast cancer cell lines: a literature-based perspective study
title_full	Cytotoxicity of synthetic derivatives against breast cancer and multi-drug resistant breast cancer cell lines: a literature-based perspective study
title_fullStr	Cytotoxicity of synthetic derivatives against breast cancer and multi-drug resistant breast cancer cell lines: a literature-based perspective study
title_full_unstemmed	Cytotoxicity of synthetic derivatives against breast cancer and multi-drug resistant breast cancer cell lines: a literature-based perspective study
title_sort	cytotoxicity of synthetic derivatives against breast cancer and multi-drug resistant breast cancer cell lines: a literature-based perspective study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/6f3615e2fe814f4ba3589a8ca1bc8259
work_keys_str_mv	AT shabnamsharmin cytotoxicityofsyntheticderivativesagainstbreastcancerandmultidrugresistantbreastcancercelllinesaliteraturebasedperspectivestudy AT mdmizanurrahaman cytotoxicityofsyntheticderivativesagainstbreastcancerandmultidrugresistantbreastcancercelllinesaliteraturebasedperspectivestudy AT miquelmartorell cytotoxicityofsyntheticderivativesagainstbreastcancerandmultidrugresistantbreastcancercelllinesaliteraturebasedperspectivestudy AT jorgesastreserra cytotoxicityofsyntheticderivativesagainstbreastcancerandmultidrugresistantbreastcancercelllinesaliteraturebasedperspectivestudy AT javadsharifirad cytotoxicityofsyntheticderivativesagainstbreastcancerandmultidrugresistantbreastcancercelllinesaliteraturebasedperspectivestudy AT monicabutnariu cytotoxicityofsyntheticderivativesagainstbreastcancerandmultidrugresistantbreastcancercelllinesaliteraturebasedperspectivestudy AT iuliacristinabagiu cytotoxicityofsyntheticderivativesagainstbreastcancerandmultidrugresistantbreastcancercelllinesaliteraturebasedperspectivestudy AT raduvasilebagiu cytotoxicityofsyntheticderivativesagainstbreastcancerandmultidrugresistantbreastcancercelllinesaliteraturebasedperspectivestudy AT mohammadtorequlislam cytotoxicityofsyntheticderivativesagainstbreastcancerandmultidrugresistantbreastcancercelllinesaliteraturebasedperspectivestudy
_version_	1718418889505767424

Cytotoxicity of synthetic derivatives against breast cancer and multi-drug resistant breast cancer cell lines: a literature-based perspective study

Ejemplares similares