The number of lymphocytes increases in the periprosthetic tissues with increasing time of implant service in non-metal-on-metal total joint arthroplasties: A role of metallic particles?

Background. The objective of the study was to determine the association between periprosthetic concentrations of selected metals and changes induced in periprosthetic tissues (PT). Methods. PT from 24 patients with metal-on-polyethylene or ceramic-on-polyethylene total joint replacements (TJRs) were...

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Autores principales:	Martin Hobza, David Milde, Zuzana Slobodova, Jiri Gallo
Formato:	article
Lenguaje:	EN
Publicado:	Palacký University Olomouc, Faculty of Medicine and Dentistry 2021
Materias:	total joint replacement aseptic loosening metal debris adverse local tissue response krenn classification; lymphocytes Medicine R
Acceso en línea:	https://doaj.org/article/6f36b697c5304b33aa686bcd734daac8
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spelling	oai:doaj.org-article:6f36b697c5304b33aa686bcd734daac82021-11-29T09:17:21ZThe number of lymphocytes increases in the periprosthetic tissues with increasing time of implant service in non-metal-on-metal total joint arthroplasties: A role of metallic particles?1213-81181804-7521https://doaj.org/article/6f36b697c5304b33aa686bcd734daac82021-11-01T00:00:00Zhttps://biomed.papers.upol.cz/artkey/bio-202104-0011_the-number-of-lymphocytes-increases-in-the-periprosthetic-tissues-with-increasing-time-of-implant-service-in-no.phphttps://doaj.org/toc/1213-8118https://doaj.org/toc/1804-7521Background. The objective of the study was to determine the association between periprosthetic concentrations of selected metals and changes induced in periprosthetic tissues (PT). Methods. PT from 24 patients with metal-on-polyethylene or ceramic-on-polyethylene total joint replacements (TJRs) were examined. Samples underwent histological examination including quantification of cellular populations. Determination of metals was performed according to the published methodology. Results were processed using correlation analysis and Principal Component Analysis (PCA), respectively. Results. Growing concentration of metals in the PT was found as a function of length of exposure (LoE). Differences in Ti, Co, Cr and V concentrations (per α = 0.05) depended on the type of alloy the implants were made from. On the contrary, the implant composition did not reflect in the different numbers of immune cells per 1 high power field, not even in distribution of the membrane type according to the Krenn classification. PCA revealed several clusters in dependence on the LoE, type of the membrane and presence of immune cells. High representation of lymphocytes in the PT was typical for clusters with the longest LoE while a higher representation of neutrophils was typical for a shorter time to reoperation. Conclusions. Correlation between the LoE and concentrations of metals in its surroundings was demonstrated. However, the tissue image analysis cannot differentiate finer, potentially metal-induced tissue changes. Importantly, the tissues become more similar with an increasing LoE. We draw a conclusion about predominantly non-specific stimulation of the PT jointly by metal and polyethylene particles in non-metal-on-metal TJRs.Martin HobzaDavid MildeZuzana SlobodovaJiri GalloPalacký University Olomouc, Faculty of Medicine and Dentistryarticletotal joint replacementaseptic looseningmetal debrisadverse local tissue responsekrenn classification; lymphocytesMedicineRENBiomedical Papers, Vol 165, Iss 4, Pp 416-427 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	total joint replacement aseptic loosening metal debris adverse local tissue response krenn classification; lymphocytes Medicine R
spellingShingle	total joint replacement aseptic loosening metal debris adverse local tissue response krenn classification; lymphocytes Medicine R Martin Hobza David Milde Zuzana Slobodova Jiri Gallo The number of lymphocytes increases in the periprosthetic tissues with increasing time of implant service in non-metal-on-metal total joint arthroplasties: A role of metallic particles?
description	Background. The objective of the study was to determine the association between periprosthetic concentrations of selected metals and changes induced in periprosthetic tissues (PT). Methods. PT from 24 patients with metal-on-polyethylene or ceramic-on-polyethylene total joint replacements (TJRs) were examined. Samples underwent histological examination including quantification of cellular populations. Determination of metals was performed according to the published methodology. Results were processed using correlation analysis and Principal Component Analysis (PCA), respectively. Results. Growing concentration of metals in the PT was found as a function of length of exposure (LoE). Differences in Ti, Co, Cr and V concentrations (per α = 0.05) depended on the type of alloy the implants were made from. On the contrary, the implant composition did not reflect in the different numbers of immune cells per 1 high power field, not even in distribution of the membrane type according to the Krenn classification. PCA revealed several clusters in dependence on the LoE, type of the membrane and presence of immune cells. High representation of lymphocytes in the PT was typical for clusters with the longest LoE while a higher representation of neutrophils was typical for a shorter time to reoperation. Conclusions. Correlation between the LoE and concentrations of metals in its surroundings was demonstrated. However, the tissue image analysis cannot differentiate finer, potentially metal-induced tissue changes. Importantly, the tissues become more similar with an increasing LoE. We draw a conclusion about predominantly non-specific stimulation of the PT jointly by metal and polyethylene particles in non-metal-on-metal TJRs.
format	article
author	Martin Hobza David Milde Zuzana Slobodova Jiri Gallo
author_facet	Martin Hobza David Milde Zuzana Slobodova Jiri Gallo
author_sort	Martin Hobza
title	The number of lymphocytes increases in the periprosthetic tissues with increasing time of implant service in non-metal-on-metal total joint arthroplasties: A role of metallic particles?
title_short	The number of lymphocytes increases in the periprosthetic tissues with increasing time of implant service in non-metal-on-metal total joint arthroplasties: A role of metallic particles?
title_full	The number of lymphocytes increases in the periprosthetic tissues with increasing time of implant service in non-metal-on-metal total joint arthroplasties: A role of metallic particles?
title_fullStr	The number of lymphocytes increases in the periprosthetic tissues with increasing time of implant service in non-metal-on-metal total joint arthroplasties: A role of metallic particles?
title_full_unstemmed	The number of lymphocytes increases in the periprosthetic tissues with increasing time of implant service in non-metal-on-metal total joint arthroplasties: A role of metallic particles?
title_sort	number of lymphocytes increases in the periprosthetic tissues with increasing time of implant service in non-metal-on-metal total joint arthroplasties: a role of metallic particles?
publisher	Palacký University Olomouc, Faculty of Medicine and Dentistry
publishDate	2021
url	https://doaj.org/article/6f36b697c5304b33aa686bcd734daac8
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The number of lymphocytes increases in the periprosthetic tissues with increasing time of implant service in non-metal-on-metal total joint arthroplasties: A role of metallic particles?

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