Adiponectin is an endogenous anti-fibrotic mediator and therapeutic target
Abstract Skin fibrosis in systemic sclerosis (SSc) is accompanied by attrition of dermal white adipose tissue (dWAT) and reduced levels of circulating adiponectin. Since adiponectin has potent regulatory effects on fibroblasts, we sought to assess adiponectin signaling in SSc skin biopsies, and eval...
Guardado en:
Autores principales: | Roberta G. Marangoni, Yuri Masui, Feng Fang, Benjamin Korman, Gabriel Lord, Junghwa Lee, Katja Lakota, Jun Wei, Philipp E. Scherer, Laszlo Otvos, Toshimasa Yamauchi, Naoto Kubota, Takashi Kadowaki, Yoshihide Asano, Shinichi Sato, Warren G. Tourtellotte, John Varga |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
|
Materias: | |
Acceso en línea: | https://doaj.org/article/6f36cafe22ea4bf78193c98c31cf6636 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity
por: Tetsuya Kubota, et al.
Publicado: (2018) -
Molecular programs of fibrotic change in aging human lung
por: Seoyeon Lee, et al.
Publicado: (2021) -
Adiponectin inhibits neutrophil phagocytosis of Escherichia coli by inhibition of PKB and ERK 1/2 MAPK signalling and Mac-1 activation.
por: Alessandra Rossi, et al.
Publicado: (2013) -
Cellular senescence mediates fibrotic pulmonary disease
por: Marissa J. Schafer, et al.
Publicado: (2017) -
Adiponectin/adiponectin receptors mRNA expression profiles in chickens and their response to feed restriction
por: Jiangxue Cai, et al.
Publicado: (2021)