Systems biology analysis of lung fibrosis-related genes in the bleomycin mouse model

Abstract Tissue fibrosis is a major driver of pathology in aging and is involved in numerous age-related diseases. The lungs are particularly susceptible to fibrotic pathology which is currently difficult to treat. The mouse bleomycin-induced fibrosis model was developed to investigate lung fibrosis...

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Autores principales:	Dmitri Toren, Hagai Yanai, Reem Abu Taha, Gabriela Bunu, Eugen Ursu, Rolf Ziesche, Robi Tacutu, Vadim E Fraifeld
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6f385b81d7a846bd95a98ccaec205d2d
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spelling	oai:doaj.org-article:6f385b81d7a846bd95a98ccaec205d2d2021-12-02T18:51:08ZSystems biology analysis of lung fibrosis-related genes in the bleomycin mouse model10.1038/s41598-021-98674-62045-2322https://doaj.org/article/6f385b81d7a846bd95a98ccaec205d2d2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98674-6https://doaj.org/toc/2045-2322Abstract Tissue fibrosis is a major driver of pathology in aging and is involved in numerous age-related diseases. The lungs are particularly susceptible to fibrotic pathology which is currently difficult to treat. The mouse bleomycin-induced fibrosis model was developed to investigate lung fibrosis and widely used over the years. However, a systematic analysis of the accumulated results has not been performed. We undertook a comprehensive data mining and subsequent manual curation, resulting in a collection of 213 genes (available at the TiRe database, www.tiredb.org ), which when manipulated had a clear impact on bleomycin-induced lung fibrosis. Our meta-analysis highlights the age component in pulmonary fibrosis and strong links of related genes with longevity. The results support the validity of the bleomycin model to human pathology and suggest the importance of a multi-target therapeutic strategy for pulmonary fibrosis treatment.Dmitri TorenHagai YanaiReem Abu TahaGabriela BunuEugen UrsuRolf ZiescheRobi TacutuVadim E FraifeldNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dmitri Toren Hagai Yanai Reem Abu Taha Gabriela Bunu Eugen Ursu Rolf Ziesche Robi Tacutu Vadim E Fraifeld Systems biology analysis of lung fibrosis-related genes in the bleomycin mouse model
description	Abstract Tissue fibrosis is a major driver of pathology in aging and is involved in numerous age-related diseases. The lungs are particularly susceptible to fibrotic pathology which is currently difficult to treat. The mouse bleomycin-induced fibrosis model was developed to investigate lung fibrosis and widely used over the years. However, a systematic analysis of the accumulated results has not been performed. We undertook a comprehensive data mining and subsequent manual curation, resulting in a collection of 213 genes (available at the TiRe database, www.tiredb.org ), which when manipulated had a clear impact on bleomycin-induced lung fibrosis. Our meta-analysis highlights the age component in pulmonary fibrosis and strong links of related genes with longevity. The results support the validity of the bleomycin model to human pathology and suggest the importance of a multi-target therapeutic strategy for pulmonary fibrosis treatment.
format	article
author	Dmitri Toren Hagai Yanai Reem Abu Taha Gabriela Bunu Eugen Ursu Rolf Ziesche Robi Tacutu Vadim E Fraifeld
author_facet	Dmitri Toren Hagai Yanai Reem Abu Taha Gabriela Bunu Eugen Ursu Rolf Ziesche Robi Tacutu Vadim E Fraifeld
author_sort	Dmitri Toren
title	Systems biology analysis of lung fibrosis-related genes in the bleomycin mouse model
title_short	Systems biology analysis of lung fibrosis-related genes in the bleomycin mouse model
title_full	Systems biology analysis of lung fibrosis-related genes in the bleomycin mouse model
title_fullStr	Systems biology analysis of lung fibrosis-related genes in the bleomycin mouse model
title_full_unstemmed	Systems biology analysis of lung fibrosis-related genes in the bleomycin mouse model
title_sort	systems biology analysis of lung fibrosis-related genes in the bleomycin mouse model
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6f385b81d7a846bd95a98ccaec205d2d
work_keys_str_mv	AT dmitritoren systemsbiologyanalysisoflungfibrosisrelatedgenesinthebleomycinmousemodel AT hagaiyanai systemsbiologyanalysisoflungfibrosisrelatedgenesinthebleomycinmousemodel AT reemabutaha systemsbiologyanalysisoflungfibrosisrelatedgenesinthebleomycinmousemodel AT gabrielabunu systemsbiologyanalysisoflungfibrosisrelatedgenesinthebleomycinmousemodel AT eugenursu systemsbiologyanalysisoflungfibrosisrelatedgenesinthebleomycinmousemodel AT rolfziesche systemsbiologyanalysisoflungfibrosisrelatedgenesinthebleomycinmousemodel AT robitacutu systemsbiologyanalysisoflungfibrosisrelatedgenesinthebleomycinmousemodel AT vadimefraifeld systemsbiologyanalysisoflungfibrosisrelatedgenesinthebleomycinmousemodel
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Systems biology analysis of lung fibrosis-related genes in the bleomycin mouse model

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