Hidden <named-content content-type="genus-species">Staphylococcus aureus</named-content> Carriage: Overrated or Underappreciated?

ABSTRACT Staphylococcus aureus is a persistent companion bacterial species in one-third of humankind. Reservoirs include the nasal and nasopharyngeal cavities, skin, and gastrointestinal (GI) tract. Despite earlier claims that colonization of individuals is caused by clonal organisms, next-generatio...

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Autor principal:	Alex van Belkum
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2016
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/6f39f11908504368834cfceb580c074f
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spelling	oai:doaj.org-article:6f39f11908504368834cfceb580c074f2021-11-15T15:49:40ZHidden <named-content content-type="genus-species">Staphylococcus aureus</named-content> Carriage: Overrated or Underappreciated?10.1128/mBio.00079-162150-7511https://doaj.org/article/6f39f11908504368834cfceb580c074f2016-03-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00079-16https://doaj.org/toc/2150-7511ABSTRACT Staphylococcus aureus is a persistent companion bacterial species in one-third of humankind. Reservoirs include the nasal and nasopharyngeal cavities, skin, and gastrointestinal (GI) tract. Despite earlier claims that colonization of individuals is caused by clonal organisms, next-generation sequencing (NGS) has revealed that resident type heterogeneity is not exceptional. Carriage, whether overt or hidden, is correlated with a risk of autoinfection. In a recent article in mBio, it was shown that, based on staphylococcal genome sequencing, low-level GI persistence may cause long-term nosocomial outbreaks [L. Senn et al., 7(1):e02039-15, 2016, doi:10.1128/mBio.02039-15]. Institutional endemicity with methicillin-resistant S. aureus (MRSA) sequence type 228 (ST228) is shown to originate not from high-level nasal carriage or poor compliance with infection control practice but from low-grade asymptomatic GI colonization. This shows the power of NGS in elucidating staphylococcal epidemiology and, even more important, demonstrates that (drug-resistant) microorganisms may possess stealthy means of persistence. Identifying these persistence mechanisms is key to successful infection control.Alex van BelkumAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 7, Iss 1 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Alex van Belkum Hidden <named-content content-type="genus-species">Staphylococcus aureus</named-content> Carriage: Overrated or Underappreciated?
description	ABSTRACT Staphylococcus aureus is a persistent companion bacterial species in one-third of humankind. Reservoirs include the nasal and nasopharyngeal cavities, skin, and gastrointestinal (GI) tract. Despite earlier claims that colonization of individuals is caused by clonal organisms, next-generation sequencing (NGS) has revealed that resident type heterogeneity is not exceptional. Carriage, whether overt or hidden, is correlated with a risk of autoinfection. In a recent article in mBio, it was shown that, based on staphylococcal genome sequencing, low-level GI persistence may cause long-term nosocomial outbreaks [L. Senn et al., 7(1):e02039-15, 2016, doi:10.1128/mBio.02039-15]. Institutional endemicity with methicillin-resistant S. aureus (MRSA) sequence type 228 (ST228) is shown to originate not from high-level nasal carriage or poor compliance with infection control practice but from low-grade asymptomatic GI colonization. This shows the power of NGS in elucidating staphylococcal epidemiology and, even more important, demonstrates that (drug-resistant) microorganisms may possess stealthy means of persistence. Identifying these persistence mechanisms is key to successful infection control.
format	article
author	Alex van Belkum
author_facet	Alex van Belkum
author_sort	Alex van Belkum
title	Hidden <named-content content-type="genus-species">Staphylococcus aureus</named-content> Carriage: Overrated or Underappreciated?
title_short	Hidden <named-content content-type="genus-species">Staphylococcus aureus</named-content> Carriage: Overrated or Underappreciated?
title_full	Hidden <named-content content-type="genus-species">Staphylococcus aureus</named-content> Carriage: Overrated or Underappreciated?
title_fullStr	Hidden <named-content content-type="genus-species">Staphylococcus aureus</named-content> Carriage: Overrated or Underappreciated?
title_full_unstemmed	Hidden <named-content content-type="genus-species">Staphylococcus aureus</named-content> Carriage: Overrated or Underappreciated?
title_sort	hidden <named-content content-type="genus-species">staphylococcus aureus</named-content> carriage: overrated or underappreciated?
publisher	American Society for Microbiology
publishDate	2016
url	https://doaj.org/article/6f39f11908504368834cfceb580c074f
work_keys_str_mv	AT alexvanbelkum hiddennamedcontentcontenttypegenusspeciesstaphylococcusaureusnamedcontentcarriageoverratedorunderappreciated
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Hidden <named-content content-type="genus-species">Staphylococcus aureus</named-content> Carriage: Overrated or Underappreciated?

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