The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35
MYCN amplification is common in neuroblastomas. Here, the authors identify a long noncoding RNA, lncNB1 in these cancers and show that it promotes tumorigenesis by binding to ribosomal protein, RPL35 to enhance E2F1 and DEPDC1B protein synthesis, which phosphorylates ERK to stabilise N-Myc.
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2019
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oai:doaj.org-article:6f4020351a1c40b79a768a93d42a3e692021-12-02T16:58:26ZThe long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL3510.1038/s41467-019-12971-32041-1723https://doaj.org/article/6f4020351a1c40b79a768a93d42a3e692019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12971-3https://doaj.org/toc/2041-1723MYCN amplification is common in neuroblastomas. Here, the authors identify a long noncoding RNA, lncNB1 in these cancers and show that it promotes tumorigenesis by binding to ribosomal protein, RPL35 to enhance E2F1 and DEPDC1B protein synthesis, which phosphorylates ERK to stabilise N-Myc.Pei Y. LiuAndrew E. TeeGiorgio MilazzoKatherine M. HannanJesper MaagSujanna MondalBernard AtmadibrataNenad BartonicekHui PengNicholas HoChelsea MayohRoberto CiaccioYuting SunMichelle J. HendersonJixuan GaoCeline EveraertAmy J. HulmeMatthew WongQing LanBelamy B. CheungLeming ShiJenny Y. WangThorsten SimonMatthias FischerXu D. ZhangGlenn M. MarshallMurray D. NorrisMichelle HaberJo VandesompeleJinyan LiPieter MestdaghRoss D. HannanMarcel E. DingerGiovanni PeriniTao LiuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019) |
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Science Q Pei Y. Liu Andrew E. Tee Giorgio Milazzo Katherine M. Hannan Jesper Maag Sujanna Mondal Bernard Atmadibrata Nenad Bartonicek Hui Peng Nicholas Ho Chelsea Mayoh Roberto Ciaccio Yuting Sun Michelle J. Henderson Jixuan Gao Celine Everaert Amy J. Hulme Matthew Wong Qing Lan Belamy B. Cheung Leming Shi Jenny Y. Wang Thorsten Simon Matthias Fischer Xu D. Zhang Glenn M. Marshall Murray D. Norris Michelle Haber Jo Vandesompele Jinyan Li Pieter Mestdagh Ross D. Hannan Marcel E. Dinger Giovanni Perini Tao Liu The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35 |
| description |
MYCN amplification is common in neuroblastomas. Here, the authors identify a long noncoding RNA, lncNB1 in these cancers and show that it promotes tumorigenesis by binding to ribosomal protein, RPL35 to enhance E2F1 and DEPDC1B protein synthesis, which phosphorylates ERK to stabilise N-Myc. |
| format |
article |
| author |
Pei Y. Liu Andrew E. Tee Giorgio Milazzo Katherine M. Hannan Jesper Maag Sujanna Mondal Bernard Atmadibrata Nenad Bartonicek Hui Peng Nicholas Ho Chelsea Mayoh Roberto Ciaccio Yuting Sun Michelle J. Henderson Jixuan Gao Celine Everaert Amy J. Hulme Matthew Wong Qing Lan Belamy B. Cheung Leming Shi Jenny Y. Wang Thorsten Simon Matthias Fischer Xu D. Zhang Glenn M. Marshall Murray D. Norris Michelle Haber Jo Vandesompele Jinyan Li Pieter Mestdagh Ross D. Hannan Marcel E. Dinger Giovanni Perini Tao Liu |
| author_facet |
Pei Y. Liu Andrew E. Tee Giorgio Milazzo Katherine M. Hannan Jesper Maag Sujanna Mondal Bernard Atmadibrata Nenad Bartonicek Hui Peng Nicholas Ho Chelsea Mayoh Roberto Ciaccio Yuting Sun Michelle J. Henderson Jixuan Gao Celine Everaert Amy J. Hulme Matthew Wong Qing Lan Belamy B. Cheung Leming Shi Jenny Y. Wang Thorsten Simon Matthias Fischer Xu D. Zhang Glenn M. Marshall Murray D. Norris Michelle Haber Jo Vandesompele Jinyan Li Pieter Mestdagh Ross D. Hannan Marcel E. Dinger Giovanni Perini Tao Liu |
| author_sort |
Pei Y. Liu |
| title |
The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35 |
| title_short |
The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35 |
| title_full |
The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35 |
| title_fullStr |
The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35 |
| title_full_unstemmed |
The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35 |
| title_sort |
long noncoding rna lncnb1 promotes tumorigenesis by interacting with ribosomal protein rpl35 |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/6f4020351a1c40b79a768a93d42a3e69 |
| work_keys_str_mv |
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