Plasma concentrations of granulocyte colony-stimulating factor (G-CSF) in patients with substance use disorders and comorbid major depressive disorder

Abstract Granulocyte colony–stimulating factor (G-CSF) has raised much interest because of its role in cocaine addiction in preclinical models. We explored the plasma concentrations of G-CSF in patients diagnosed with substance use disorder (SUD) and highly comorbid psychiatric disorders. In particu...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sandra Torres Galván, María Flores-López, Pablo Romero-Sanchiz, Nerea Requena-Ocaña, Oscar Porras-Perales, Raquel Nogueira-Arjona, Fermín Mayoral, Pedro Araos, Antonia Serrano, Roberto Muga, Francisco Javier Pavón, Nuria García-Marchena, Fernando Rodríguez de Fonseca
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6f43e600c64547b9884197f9ae16ec94
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6f43e600c64547b9884197f9ae16ec94
record_format	dspace
spelling	oai:doaj.org-article:6f43e600c64547b9884197f9ae16ec942021-12-02T14:33:51ZPlasma concentrations of granulocyte colony-stimulating factor (G-CSF) in patients with substance use disorders and comorbid major depressive disorder10.1038/s41598-021-93075-12045-2322https://doaj.org/article/6f43e600c64547b9884197f9ae16ec942021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93075-1https://doaj.org/toc/2045-2322Abstract Granulocyte colony–stimulating factor (G-CSF) has raised much interest because of its role in cocaine addiction in preclinical models. We explored the plasma concentrations of G-CSF in patients diagnosed with substance use disorder (SUD) and highly comorbid psychiatric disorders. In particular, we investigated the association between G-CSF concentrations and comorbid major depressive disorder (MDD) in patients with cocaine and alcohol use disorders (CUD and AUD, respectively). Additionally, patients with MDD but not SUD were included in the study. Three hundred and eleven participants were enrolled in this exploratory study: 136 control subjects, 125 patients with SUD (SUD group) from outpatient treatment programs for cocaine (N = 60, cocaine subgroup) and alcohol (N = 65, alcohol subgroup), and 50 patients with MDD but not SUD (MDD group) from primary-care settings. Participants were assessed based on DSM-IV-TR criteria, and a blood sample was collected to examine the plasma concentrations of G-CSF. G-CSF concentrations were negatively correlated with age in the entire sample (r = − 0.233, p < 0.001) but not in the patients with MDD. G-CSF concentrations were lower in patients with SUD than in controls (p < 0.05), specifically in the cocaine subgroup (p < 0.05). Patients with SUD and comorbid MDD had lower G-CSF concentrations than patients with SUD but not comorbid MDD or controls (p < 0.05). In contrast, patients with MDD but not SUD showed no differences compared with their controls. The negative association between G-CSF concentrations and age in the sample was not observed in patients with MDD. G-CSF concentrations were decreased in patients with SUD and comorbid MDD but not in patients with MDD. Therefore, G-CSF may be useful to improve the stratification of patients with dual diagnosis seeking treatment. Further investigation is needed to explore the impact of sex and type of drug on the expression of G-CSF.Sandra Torres GalvánMaría Flores-LópezPablo Romero-SanchizNerea Requena-OcañaOscar Porras-PeralesRaquel Nogueira-ArjonaFermín MayoralPedro AraosAntonia SerranoRoberto MugaFrancisco Javier PavónNuria García-MarchenaFernando Rodríguez de FonsecaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sandra Torres Galván María Flores-López Pablo Romero-Sanchiz Nerea Requena-Ocaña Oscar Porras-Perales Raquel Nogueira-Arjona Fermín Mayoral Pedro Araos Antonia Serrano Roberto Muga Francisco Javier Pavón Nuria García-Marchena Fernando Rodríguez de Fonseca Plasma concentrations of granulocyte colony-stimulating factor (G-CSF) in patients with substance use disorders and comorbid major depressive disorder
description	Abstract Granulocyte colony–stimulating factor (G-CSF) has raised much interest because of its role in cocaine addiction in preclinical models. We explored the plasma concentrations of G-CSF in patients diagnosed with substance use disorder (SUD) and highly comorbid psychiatric disorders. In particular, we investigated the association between G-CSF concentrations and comorbid major depressive disorder (MDD) in patients with cocaine and alcohol use disorders (CUD and AUD, respectively). Additionally, patients with MDD but not SUD were included in the study. Three hundred and eleven participants were enrolled in this exploratory study: 136 control subjects, 125 patients with SUD (SUD group) from outpatient treatment programs for cocaine (N = 60, cocaine subgroup) and alcohol (N = 65, alcohol subgroup), and 50 patients with MDD but not SUD (MDD group) from primary-care settings. Participants were assessed based on DSM-IV-TR criteria, and a blood sample was collected to examine the plasma concentrations of G-CSF. G-CSF concentrations were negatively correlated with age in the entire sample (r = − 0.233, p < 0.001) but not in the patients with MDD. G-CSF concentrations were lower in patients with SUD than in controls (p < 0.05), specifically in the cocaine subgroup (p < 0.05). Patients with SUD and comorbid MDD had lower G-CSF concentrations than patients with SUD but not comorbid MDD or controls (p < 0.05). In contrast, patients with MDD but not SUD showed no differences compared with their controls. The negative association between G-CSF concentrations and age in the sample was not observed in patients with MDD. G-CSF concentrations were decreased in patients with SUD and comorbid MDD but not in patients with MDD. Therefore, G-CSF may be useful to improve the stratification of patients with dual diagnosis seeking treatment. Further investigation is needed to explore the impact of sex and type of drug on the expression of G-CSF.
format	article
author	Sandra Torres Galván María Flores-López Pablo Romero-Sanchiz Nerea Requena-Ocaña Oscar Porras-Perales Raquel Nogueira-Arjona Fermín Mayoral Pedro Araos Antonia Serrano Roberto Muga Francisco Javier Pavón Nuria García-Marchena Fernando Rodríguez de Fonseca
author_facet	Sandra Torres Galván María Flores-López Pablo Romero-Sanchiz Nerea Requena-Ocaña Oscar Porras-Perales Raquel Nogueira-Arjona Fermín Mayoral Pedro Araos Antonia Serrano Roberto Muga Francisco Javier Pavón Nuria García-Marchena Fernando Rodríguez de Fonseca
author_sort	Sandra Torres Galván
title	Plasma concentrations of granulocyte colony-stimulating factor (G-CSF) in patients with substance use disorders and comorbid major depressive disorder
title_short	Plasma concentrations of granulocyte colony-stimulating factor (G-CSF) in patients with substance use disorders and comorbid major depressive disorder
title_full	Plasma concentrations of granulocyte colony-stimulating factor (G-CSF) in patients with substance use disorders and comorbid major depressive disorder
title_fullStr	Plasma concentrations of granulocyte colony-stimulating factor (G-CSF) in patients with substance use disorders and comorbid major depressive disorder
title_full_unstemmed	Plasma concentrations of granulocyte colony-stimulating factor (G-CSF) in patients with substance use disorders and comorbid major depressive disorder
title_sort	plasma concentrations of granulocyte colony-stimulating factor (g-csf) in patients with substance use disorders and comorbid major depressive disorder
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6f43e600c64547b9884197f9ae16ec94
work_keys_str_mv	AT sandratorresgalvan plasmaconcentrationsofgranulocytecolonystimulatingfactorgcsfinpatientswithsubstanceusedisordersandcomorbidmajordepressivedisorder AT mariafloreslopez plasmaconcentrationsofgranulocytecolonystimulatingfactorgcsfinpatientswithsubstanceusedisordersandcomorbidmajordepressivedisorder AT pabloromerosanchiz plasmaconcentrationsofgranulocytecolonystimulatingfactorgcsfinpatientswithsubstanceusedisordersandcomorbidmajordepressivedisorder AT nerearequenaocana plasmaconcentrationsofgranulocytecolonystimulatingfactorgcsfinpatientswithsubstanceusedisordersandcomorbidmajordepressivedisorder AT oscarporrasperales plasmaconcentrationsofgranulocytecolonystimulatingfactorgcsfinpatientswithsubstanceusedisordersandcomorbidmajordepressivedisorder AT raquelnogueiraarjona plasmaconcentrationsofgranulocytecolonystimulatingfactorgcsfinpatientswithsubstanceusedisordersandcomorbidmajordepressivedisorder AT ferminmayoral plasmaconcentrationsofgranulocytecolonystimulatingfactorgcsfinpatientswithsubstanceusedisordersandcomorbidmajordepressivedisorder AT pedroaraos plasmaconcentrationsofgranulocytecolonystimulatingfactorgcsfinpatientswithsubstanceusedisordersandcomorbidmajordepressivedisorder AT antoniaserrano plasmaconcentrationsofgranulocytecolonystimulatingfactorgcsfinpatientswithsubstanceusedisordersandcomorbidmajordepressivedisorder AT robertomuga plasmaconcentrationsofgranulocytecolonystimulatingfactorgcsfinpatientswithsubstanceusedisordersandcomorbidmajordepressivedisorder AT franciscojavierpavon plasmaconcentrationsofgranulocytecolonystimulatingfactorgcsfinpatientswithsubstanceusedisordersandcomorbidmajordepressivedisorder AT nuriagarciamarchena plasmaconcentrationsofgranulocytecolonystimulatingfactorgcsfinpatientswithsubstanceusedisordersandcomorbidmajordepressivedisorder AT fernandorodriguezdefonseca plasmaconcentrationsofgranulocytecolonystimulatingfactorgcsfinpatientswithsubstanceusedisordersandcomorbidmajordepressivedisorder
_version_	1718391134850383872

Plasma concentrations of granulocyte colony-stimulating factor (G-CSF) in patients with substance use disorders and comorbid major depressive disorder

Ejemplares similares