Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy

Neural tube defects can arise from high glucose levels caused by maternal diabetes, and MARCKS is required for neural tube closure. Here, Yang et al. show that acetylation and phosphorylation of MARCKS in hyperglycemic conditions causes mitochondrial and ER stress, leading to neural tube defects.

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Detalles Bibliográficos
Autores principales:	Penghua Yang, Cheng Xu, E. Albert Reece, Xi Chen, Jianxiang Zhong, Min Zhan, Deborah J. Stumpo, Perry J. Blackshear, Peixin Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6f49908709a549058f956b7c2ba701a2
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spelling	oai:doaj.org-article:6f49908709a549058f956b7c2ba701a22021-12-02T15:35:51ZTip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy10.1038/s41467-018-08268-62041-1723https://doaj.org/article/6f49908709a549058f956b7c2ba701a22019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08268-6https://doaj.org/toc/2041-1723Neural tube defects can arise from high glucose levels caused by maternal diabetes, and MARCKS is required for neural tube closure. Here, Yang et al. show that acetylation and phosphorylation of MARCKS in hyperglycemic conditions causes mitochondrial and ER stress, leading to neural tube defects.Penghua YangCheng XuE. Albert ReeceXi ChenJianxiang ZhongMin ZhanDeborah J. StumpoPerry J. BlackshearPeixin YangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Penghua Yang Cheng Xu E. Albert Reece Xi Chen Jianxiang Zhong Min Zhan Deborah J. Stumpo Perry J. Blackshear Peixin Yang Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy
description	Neural tube defects can arise from high glucose levels caused by maternal diabetes, and MARCKS is required for neural tube closure. Here, Yang et al. show that acetylation and phosphorylation of MARCKS in hyperglycemic conditions causes mitochondrial and ER stress, leading to neural tube defects.
format	article
author	Penghua Yang Cheng Xu E. Albert Reece Xi Chen Jianxiang Zhong Min Zhan Deborah J. Stumpo Perry J. Blackshear Peixin Yang
author_facet	Penghua Yang Cheng Xu E. Albert Reece Xi Chen Jianxiang Zhong Min Zhan Deborah J. Stumpo Perry J. Blackshear Peixin Yang
author_sort	Penghua Yang
title	Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy
title_short	Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy
title_full	Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy
title_fullStr	Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy
title_full_unstemmed	Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy
title_sort	tip60- and sirtuin 2-regulated marcks acetylation and phosphorylation are required for diabetic embryopathy
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6f49908709a549058f956b7c2ba701a2
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Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy

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