Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy

Neural tube defects can arise from high glucose levels caused by maternal diabetes, and MARCKS is required for neural tube closure. Here, Yang et al. show that acetylation and phosphorylation of MARCKS in hyperglycemic conditions causes mitochondrial and ER stress, leading to neural tube defects.

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Autores principales: Penghua Yang, Cheng Xu, E. Albert Reece, Xi Chen, Jianxiang Zhong, Min Zhan, Deborah J. Stumpo, Perry J. Blackshear, Peixin Yang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/6f49908709a549058f956b7c2ba701a2
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spelling oai:doaj.org-article:6f49908709a549058f956b7c2ba701a22021-12-02T15:35:51ZTip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy10.1038/s41467-018-08268-62041-1723https://doaj.org/article/6f49908709a549058f956b7c2ba701a22019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08268-6https://doaj.org/toc/2041-1723Neural tube defects can arise from high glucose levels caused by maternal diabetes, and MARCKS is required for neural tube closure. Here, Yang et al. show that acetylation and phosphorylation of MARCKS in hyperglycemic conditions causes mitochondrial and ER stress, leading to neural tube defects.Penghua YangCheng XuE. Albert ReeceXi ChenJianxiang ZhongMin ZhanDeborah J. StumpoPerry J. BlackshearPeixin YangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Penghua Yang
Cheng Xu
E. Albert Reece
Xi Chen
Jianxiang Zhong
Min Zhan
Deborah J. Stumpo
Perry J. Blackshear
Peixin Yang
Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy
description Neural tube defects can arise from high glucose levels caused by maternal diabetes, and MARCKS is required for neural tube closure. Here, Yang et al. show that acetylation and phosphorylation of MARCKS in hyperglycemic conditions causes mitochondrial and ER stress, leading to neural tube defects.
format article
author Penghua Yang
Cheng Xu
E. Albert Reece
Xi Chen
Jianxiang Zhong
Min Zhan
Deborah J. Stumpo
Perry J. Blackshear
Peixin Yang
author_facet Penghua Yang
Cheng Xu
E. Albert Reece
Xi Chen
Jianxiang Zhong
Min Zhan
Deborah J. Stumpo
Perry J. Blackshear
Peixin Yang
author_sort Penghua Yang
title Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy
title_short Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy
title_full Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy
title_fullStr Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy
title_full_unstemmed Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy
title_sort tip60- and sirtuin 2-regulated marcks acetylation and phosphorylation are required for diabetic embryopathy
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/6f49908709a549058f956b7c2ba701a2
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AT chengxu tip60andsirtuin2regulatedmarcksacetylationandphosphorylationarerequiredfordiabeticembryopathy
AT ealbertreece tip60andsirtuin2regulatedmarcksacetylationandphosphorylationarerequiredfordiabeticembryopathy
AT xichen tip60andsirtuin2regulatedmarcksacetylationandphosphorylationarerequiredfordiabeticembryopathy
AT jianxiangzhong tip60andsirtuin2regulatedmarcksacetylationandphosphorylationarerequiredfordiabeticembryopathy
AT minzhan tip60andsirtuin2regulatedmarcksacetylationandphosphorylationarerequiredfordiabeticembryopathy
AT deborahjstumpo tip60andsirtuin2regulatedmarcksacetylationandphosphorylationarerequiredfordiabeticembryopathy
AT perryjblackshear tip60andsirtuin2regulatedmarcksacetylationandphosphorylationarerequiredfordiabeticembryopathy
AT peixinyang tip60andsirtuin2regulatedmarcksacetylationandphosphorylationarerequiredfordiabeticembryopathy
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