Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy
Neural tube defects can arise from high glucose levels caused by maternal diabetes, and MARCKS is required for neural tube closure. Here, Yang et al. show that acetylation and phosphorylation of MARCKS in hyperglycemic conditions causes mitochondrial and ER stress, leading to neural tube defects.
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Nature Portfolio
2019
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oai:doaj.org-article:6f49908709a549058f956b7c2ba701a22021-12-02T15:35:51ZTip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy10.1038/s41467-018-08268-62041-1723https://doaj.org/article/6f49908709a549058f956b7c2ba701a22019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08268-6https://doaj.org/toc/2041-1723Neural tube defects can arise from high glucose levels caused by maternal diabetes, and MARCKS is required for neural tube closure. Here, Yang et al. show that acetylation and phosphorylation of MARCKS in hyperglycemic conditions causes mitochondrial and ER stress, leading to neural tube defects.Penghua YangCheng XuE. Albert ReeceXi ChenJianxiang ZhongMin ZhanDeborah J. StumpoPerry J. BlackshearPeixin YangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019) |
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Science Q Penghua Yang Cheng Xu E. Albert Reece Xi Chen Jianxiang Zhong Min Zhan Deborah J. Stumpo Perry J. Blackshear Peixin Yang Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy |
description |
Neural tube defects can arise from high glucose levels caused by maternal diabetes, and MARCKS is required for neural tube closure. Here, Yang et al. show that acetylation and phosphorylation of MARCKS in hyperglycemic conditions causes mitochondrial and ER stress, leading to neural tube defects. |
format |
article |
author |
Penghua Yang Cheng Xu E. Albert Reece Xi Chen Jianxiang Zhong Min Zhan Deborah J. Stumpo Perry J. Blackshear Peixin Yang |
author_facet |
Penghua Yang Cheng Xu E. Albert Reece Xi Chen Jianxiang Zhong Min Zhan Deborah J. Stumpo Perry J. Blackshear Peixin Yang |
author_sort |
Penghua Yang |
title |
Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy |
title_short |
Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy |
title_full |
Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy |
title_fullStr |
Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy |
title_full_unstemmed |
Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy |
title_sort |
tip60- and sirtuin 2-regulated marcks acetylation and phosphorylation are required for diabetic embryopathy |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/6f49908709a549058f956b7c2ba701a2 |
work_keys_str_mv |
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