Basal cell carcinoma: variation in invasion depth by subtype, sex, and anatomic site in 4,565 cases
Background: The depth of invasion by basal cell carcinoma (BCC) subtypes varies. Objective: To investigate BCC invasion depth variation by subtype and anatomic site. Method: A prospective consecutive case series of excised BCC from 2009 to 2014 in a single Australian clinic. Results: Descendin...
Guardado en:
| Autores principales: | , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Mattioli1885
2018
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/6f510b2d48d54e44bdd521343d34de5b |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| Sumario: | Background: The depth of invasion by basal cell carcinoma (BCC) subtypes varies.
Objective: To investigate BCC invasion depth variation by subtype and anatomic site.
Method: A prospective consecutive case series of excised BCC from 2009 to 2014 in a single Australian clinic.
Results: Descending mean depths for a total of 4,565 BCC cases by subtype were as follows: nodulocystic, 1.9 mm (n = 84, 95% CI: 1.70–2.03, P = 0.66); nodular, 1.6 mm (n = 947, 95% CI: 1.53–1.63, P < 0.0001); aggressive, 1.5 mm (n = 925, 95% CI: 1.44–1.59, P < 0.0001); superficial combined with nodular, 0.9 mm (n = 1,081, 95% CI: 0.83-0.90, P < 0.0001); and superficial, 0.3 mm (n = 1,528, 95% CI: 0.32-0.36, P < 0.0001). Deeper invasion was associated with increased chronic sunlight exposed sites. The deepest aggressive BCCs occurred on the neck with a mean depth of 1.8 mm (n = 46, 95% CI:1.47–2.21).
Conclusion: We found significant differences in the depth of invasion for BCCs by sex, subtype, and anatomic site. For BCC with characteristics matching this study, overall adequate microscopic excision depths are proposed: superficial, 1.0 mm; superficial combined with nodular, 2.0 mm; nodular, 3.0 mm; and aggressive, 3.0 mm.
|
|---|